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Mashup Score: 2Renin Cell Development: Insights From Chromatin Accessibility and Single-Cell Transcriptomics - 8 month(s) ago
Division of Nephrology, Ann and Robert H. Lurie Children’s Hospital of Chicago, IL (G.F.). Center for Public Health Genomics (N.C.S.), University of Virginia, Charlottesville. Departments of Public Health Sciences (N.C.S.), University of Virginia, Charlottesville. Biomedical Engineering (N.C.S.), University of Virginia, Charlottesville. Biochemistry and Molecular Genetics (N.C.S.), University of Virginia, Charlottesville. Maria Luisa S. Sequeira-Lopez, MD, 409 Ln Rd, Rooms 2001, 2006, and 2010, Charlottesv
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Renin-Angiotensin System Modulation in Adults With COVID-19 - 1 year(s) ago
These 2 randomized clinical trials compare the efficacy and safety of renin-angiotensin system (RAS) modulation using 2 investigational RAS agents, TXA-127 vs placebo and TRV-027 vs placebo, in adults hospitalized with severe COVID-19.
Source: jamanetwork.comCategories: Latest Headlines, PulmonologyTweet-
#Renin-Angiotensin System Modulation With #Synthetic #Angiotensin (1-7) and Angiotensin II Type 1 #Receptor–Biased Ligand in Adults With #COVID19 https://t.co/vX87EOeYtD https://t.co/TCcIFgKhJZ
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Mashup Score: 0
November 9, 2022 — CinCor Pharma, Inc. announced the presentation today of Phase 2 data from its BrigHtn trial as part of the late-breaking science session at the 2022 American Heart Association (AHA) Scientific Sessions. Baxdrostat is a highly selective, once daily oral small molecule inhibitor of aldosterone synthase. “We were honored to present our Phase 2 BrigHtn data as part of a…
Source: DAICCategories: Cardiologists, Latest HeadlinesTweet-
@DAICeditor @cincorpharma #Aldosterone and #renin biomarker activity clinically demonstrate how #baxdrostat mechanistically achieves selective #bloodpressure lowering effects with no impact on #cortisol: https://t.co/M6DPvTsyAe #AHA22
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Mashup Score: 0Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial | Oxford Academic - 2 year(s) ago
This PDF is available to Subscribers Only View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription. Close
Source: academic.oup.comCategories: Cardiologists, Latest HeadlinesTweet-
The impact of Patiromer in patients with heart failure and reduced ejection fraction: #EHJ news from the DIAMOND trial! #Heart #failure #renin-angiotensin #aldosterone #inhibitors# hyperkalemia #patiromer #cardiotwitter #ehj @ESC_Journals @escardio https://t.co/RjW4qOaEOG https://t.co/UUUfIBOall
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Mashup Score: 2
People with AVRI using ACEi/ARBs for HTN had a greater increase in poor outcomes during the COVID-19 pandemic than those using other medications to treat HTN. The small absolute magnitude of the differences likely does not support changes in clinical practice.
Source: PubMedCategories: Latest Headlines, PulmonologyTweet-
Association of outpatient use of #renin- #angiotensin- #aldosterone #system #blockers on outcomes of #acute #respiratory #illness during the #COVID-19 #pandemic: a cohort study https://t.co/HyUFFKAtgM https://t.co/c7ZUGmOVqE
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Mashup Score: 1Why the renin–angiotensin–aldosterone system (RAAS) in critically ill patients can no longer be ignored - Critical Care - 2 year(s) ago
Critical Care volume 25, Article number: 389 (2021) Cite this article …
Source: Critical CareCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Mind the #RAAS in critically ill patients! https://t.co/UrcvF1cB70 #FOAMed #FOAMcc #BMC #ICU #IntensiveCare #renin #angiotensin #aldosterone @jlvincen @ISICEM https://t.co/06D7N8lc1A
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Mashup Score: 1Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure - 3 year(s) ago
MicroRNA miR-181a is downregulated in the kidneys of hypertensive patients and hypertensive mice. In vitro, miR-181a is a posttranslational inhibitor of renin expression, but pleiotropic mechanisms b
Source: HypertensionCategories: Cardiology News and Journals, Latest HeadlinesTweet-
This study led by @FZMarques and @GeoffreyHead combines a new #CRISPR_Cas9 model #RNAScope @ACDbio and #scRNA_seq technology with traditional techniques such as telemetry and #renin #IHC to describe how #miR181a regulates #BloodPressure #MicroRNA #SSBP. https://t.co/AmjN6duS2C https://t.co/jmCqTDgiVI
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Mashup Score: 2
Rationale: Renin-expressing cells are myoendocrine cells crucial for survival. They have been postulated to possess a pressure-sensing mechanism, a baroreceptor, which can detect slight changes in bl
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Watanabe et al found the #baroreceptor in the renin cell is a nuclear mechanotransducer that senses changes in pressure via lamin A/C to control #renin expression. Learn more at https://t.co/26QEaifSj7 @MLSequeiraLopez @BanfieldGomez @belyea_brian https://t.co/pDJWayzPgs
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Mashup Score: 4Renin Cells, the Kidney, and Hypertension - 3 year(s) ago
Renin cells are essential for survival perfected throughout evolution to ensure normal development and defend the organism against a variety of homeostatic threats. During embryonic and early postnat
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
@CircRes #Hypertension Compendium Alert! #Renin Cells, The #Kidney, and #Hypertension https://t.co/inj9RIvLMm Authored by: Drs. M Sequeira-Lopez and R Gomez @MLSequeiraLopez @BanfieldGomez https://t.co/xZMghHnDMB
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Mashup Score: 0
The accelerating effect of sodium reduction on PRA towards a sodium intake of zero mmol/24 h probably explains the interstudy variability. Further studies are needed to test whether this stimulating effect on PRA reflects a physiological disadvantage potentially associated with increased mortality
Source: EClinicalMedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
📣Research Article: Influence of #sodium intake and change in sodium intake on plasma- #renin in man. Available #openaccess 👇 https://t.co/CYASmvyDKP
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Martini & colleagues provide the first developmental trajectory of #renin cells in a single-cell atlas of #kidney #vascular development. Learn how #MEF2 and #NFI transcription factors control renin cell fate at https://t.co/6xNKom1P4F https://t.co/FQRXb4qlCO