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    Prenatal exposure in the 1960s and ’70s to dicyclomine, a component of the anti-nausea drug Bendectin, increased the risk for colorectal cancer in adult offspring, according to data reported in JNCI Cancer Spectrum. “In the 1960s, Bendectin (doxylamine/pyridoxine/dicyclomine) was frequently prescribed to pregnant women to manage nausea and vomiting. Bendectin was initially approved

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    • #Prenatal exposure in the 1960s and ’70s to #dicyclomine, a component of the anti-#nausea drug #Bendectin, increased the risk for #colorectalcancer in adult #offspring, according to data reported in @JNCI_Now #ColorectalCancerAwarenessMonth #GITwitter https://t.co/mseByh8wyA

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    Paper from the JCPP Special Issue: Annual Research Review 2023 – ‘Opioid use during pregnancy impacts the health and well-being of two generations: the pregnant person and the child. The factors that increase risk for opioid use in the adult, as well as those that perpetuate risk for the caregiver and child, oftentimes replicate across generations and may be more likely to affect child…

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    • In this #AnnualResearchReview paper, Elisabeth Conradt (@DukePsychiatry) et al. explore #Prenatal #Opioid exposure using a two-generation approach to conceptualizing #Neurodevelopmental outcomes. @acamh members can read the full paper. https://t.co/ATebFuXKgD

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    The nutritional environment during development periods induces metabolic programming, leading to metabolic disorders and detrimental influences on human reproductive health. This study aimed to determine the long-term adverse effect of intrauterine malnutrition on the reproductive center kisspeptin-neurokinin B-dynorphin A (KNDy) neurons in the hypothalamic arcuate nucleus (ARC) of female…

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    • 'Long-term effects of prenatal undernutrition on female rat hypothalamic KNDy neurons' is a recently published research article by Shiori Minabe et al. https://t.co/vaJJRfy2KB #LowBirthWeight #FetalPrograming #Kisspeptin #Prenatal #Undernutrition https://t.co/U2yuICdWPU