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Mashup Score: 8Sex Differences in the Association of Genome-Wide Systolic Blood Pressure Polygenic Risk Score With Hypertension - 7 month(s) ago
School of Nursing, University of Alabama at Birmingham. (P.L.) Department of Biostatistics, University of Alabama at Birmingham. (M.G.) Correspondence to: Pankaj Arora, MD, Division of Cardiovascular Disease, The University of Alabama at Birmingham, 1670 University Blvd, Volker Hall B140, Birmingham, AL 35294-0019. Email Section of Cardiology, Birmingham Veterans Affairs Medical Center, AL (P.A.). For Sources of Funding and Disclosures, see page xxx. This article was sent to Ruth McPherson, MD, PhD,
Source: www.ahajournals.orgCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 5Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis - 7 month(s) ago
Background: Lp(a) (lipoprotein[a]) is a highly atherogenic lipoprotein subfraction that may contribute to polygenic risk of coronary artery disease (CAD), but the extent of this contribution is unkno
Source: www.ahajournals.orgCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 1Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel - 9 month(s) ago
Background Polygenic risk score (PRS), calculated based on genome-wide association studies (GWASs), can improve breast cancer (BC) risk assessment. To date, most BC GWASs have been performed in individuals of European (EUR) ancestry, and the generalisation of EUR-based PRS to other populations is a major challenge. In this study, we examined the performance of EUR-based BC PRS models in Ashkenazi…
Source: Journal of Medical GeneticsCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 1Coronary Artery Calcium and Polygenic Risk Scores to Predict CHD - 11 month(s) ago
This study involving 2 large, community-based, longitudinal, cohort studies whether adding 2 markers—coronary artery calcium score and polygenic risk score—to traditional risk factor–based scores improves predicting coronary heart disease among middle-aged to older adults.
Source: jamanetwork.comCategories: Hem/Oncs, Latest HeadlinesTweet-
.@NIH_NHLBI-funded: In 2 population-based studies involving 3208 adults aged 45-79 years and of #European ancestry, the coronary artery #calcium score but not the #polygenic risk score improved #coronary #HeartDisease risk discrimination. @HeartDocSadiya https://t.co/ZZLtI8p82u https://t.co/Ah6fQ5s6uH
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Mashup Score: 1Resources - 1 year(s) ago
ADHD 2022This set of slides provides an overview of the diagnosis and treatment of ADHD. It can be used as a presentation meant to be given by someone with prior knowledge of these topics. Feel free to add or delete slides to this set to accommodate your audience.International Consensus StatementThis set of 370 slides is not meant to be a single presentation. Instead, it is meant to provide…
Source: www.adhdevidence.orgCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 0A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels - Nature Genetics - 1 year(s) ago
This study presents a method for constructing complex trait polygenic scores from rare variants and shows that a polygenic score combining common and rare variants improves the accuracy of diagnosis for type 2 diabetes based on hemoglobin A1C levels.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
.@NIH-funded study from @BroadInstitute & @HarvardMed shows that a #polygenic score combining common & rare #variants could identify 4.9 million misdiagnosed Type 2 #diabetes cases in #USA—nearly 1.5-fold more than the common variant #PGS alone. #genetics https://t.co/UikcheNSYY https://t.co/epxf3S7swG
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Mashup Score: 0Measured Blood Pressure, Genetically Predicted Blood Pressure, and Cardiovascular Disease Risk in the UK Biobank - 1 year(s) ago
This cohort study investigates if genetic predisposition to hypertension is associated with cardiovascular disease risk beyond measured blood pressure.
Source: jamanetwork.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease - BMC Medicine - 1 year(s) ago
Background The value of polygenic risk scores (PRSs) towards improving guideline-recommended clinical risk models for coronary artery disease (CAD) prediction is controversial. Here we examine whether an integrated polygenic risk score improves the prediction of CAD beyond pooled cohort equations. Methods An observation study of 291,305 unrelated White British UK Biobank participants enrolled…
Source: BioMed CentralCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 0UK Biobank release and systematic evaluation of optimised polygenic risk scores for 53 diseases and quantitative traits - 2 year(s) ago
We present and assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28 diseases and 25 quantitative traits being made available on the individuals in UKB. We also release a benchmarking software tool to enable like-for-like performance evaluation for different PRSs for the same disease or trait. Extensive benchmarking shows the PRSs in the UKB Release to outperform a…
Source: medRxivCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 1Airway inflammation in adolescents and elderly women: Chronic air pollution exposure and polygenic susceptibility - PubMed - 2 year(s) ago
FeNO measurement is a useful biomarker to detect higher risk of NO2-induced eosinophilic airway inflammation in the elderly. There was limited evidence for GxE effects on airway inflammation in adolescents or the elderly. Further GxE studies in subpopulations should be conducted to invest …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
Just out @Circ_Gen Sex Differences in the Association of Genome-Wide Systolic Blood Pressure #Polygenic Risk Score With #Hypertension. Congrats Dr Pankaj Arora and team! @GenPrecisionMed @AHAScience @uk_biobank #CardioTwitter https://t.co/FBgsKSKxbS https://t.co/LdZ1WaRgfs