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Mashup Score: 0
Background Type 2 diabetes (T2D) is expected to worsen the prognosis of inpatients with heart failure (HF) but the evidence from observational studies is inconsistent. We aimed to compare mortality outcomes and life expectancy among inpatients with HF with or without T2D and explored whether chronic kidney disease (CKD) influenced these associations. Methods We collected hospital and civil…
Source: BioMed CentralCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 2Metagenomic assessment of gut microbial communities and risk of severe COVID-19 - Genome Medicine - 1 year(s) ago
Background The gut microbiome is a critical modulator of host immunity and is linked to the immune response to respiratory viral infections. However, few studies have gone beyond describing broad compositional alterations in severe COVID-19, defined as acute respiratory or other organ failure. Methods We profiled 127 hospitalized patients with COVID-19 (n = 79 with severe COVID-19 and 48 with…
Source: BioMed CentralCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A study published in @GenomeMedicine finds that gut microbiome differentiates individuals with a more severe disease course after infection with COVID-19 and may be a potential biomarker for disease severity. Further research is warranted. https://t.co/EJQuBa08Ea
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Mashup Score: 1Management of penile post-circumcision ischemia by pentoxifylline infusion and hyperbaric oxygen therapy - BMC Urology - 1 year(s) ago
Background Post-circumcision penile ischemia is a devastating complication. We will present our experience in managing children with various forms of penile ischemia. Materials and methods This cohort prospective observational and interventional study was performed on all male children with post-circumcision penile ischemia between April 2017 and October 2021. A designed and approved protocol…
Source: BioMed CentralCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
In children with post-circumcision penile ischemia, a combination of hyperbaric oxygen therapy and pentoxifylline is especially effective for skin and facial necrosis, and reduces penile tissue loss, finds a study published in #BMCUrol https://t.co/58AIaRRc6c
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Mashup Score: 0Protein length distribution is remarkably uniform across the tree of life - Genome Biology - 1 year(s) ago
Background In every living species, the function of a protein depends on its organization of structural domains, and the length of a protein is a direct reflection of this. Because every species evolved under different evolutionary pressures, the protein length distribution, much like other genomic features, is expected to vary across species but has so far been scarcely studied. Results Here we…
Source: BioMed CentralCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A study in @GenomeBiology finds that protein length distribution is a remarkably consistent feature across species. This is in contrast to other genomic features, suggesting that protein length may be subject to unique evolutionary constraints. https://t.co/coboUnagpt
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Mashup Score: 2The emerging role of MicroRNA-182 in tumorigenesis; a promising therapeutic target - Cancer Cell International - 1 year(s) ago
A wide range of studies have indicated that microRNAs (miRNAs), a type of small single-stranded regulatory RNAs, are dysregulated in a different variety of human cancers. Therefore, they are expected to play important roles in tumorigenesis by functioning as oncogenic (oncomiRs) or tumor-suppressive miRNAs. Subsequently, their potential as diagnostic and therapeutic targets for malignancies has…
Source: BioMed CentralCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A Review published in Cancer Cell International discusses the effects of miR-182 dysregulation on the signaling pathways involved in tumorigenesis and finds that miRNA- 182 can be a promising target in the treatment and diagnosis of various malignancies. https://t.co/SKIeEfk95J
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Mashup Score: 14
Background Suboptimal treatment upon progression may affect overall survival (OS) results in oncology randomized controlled trials (RCTs). We aim to assess the proportion of trials reporting post-progression treatment. Methods This cross-sectional analysis included two concurrent analyses. The first one examined all published RCTs of anti-cancer drugs in six high impact medical/oncology journals…
Source: BioMed CentralCategories: Hem/Oncs, Latest HeadlinesTweet-
Shameful comment. @Timothee_MD has mapped all post protocol treatment in FDA trials and sees repeatedly trialists make this argument which harms the contol arm so they can win. V unfortunate Paper here https://t.co/rMgrNPADL9 https://t.co/OJdVxZBvRI
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Mashup Score: 0Effective communications strategies to increase the impact of environmental health research - Environmental Health - 1 year(s) ago
Background Per- and polyfluoroalkyl substances (PFAS) are the subject of a growing body of research with the potential to positively impact public and ecological health. However, to effect positive change, findings must be communicated beyond the scientific community. Objective We sought to (a) evaluate the relationships between communications strategy, media attention, and scholarly citations of…
Source: BioMed CentralCategories: General Medicine News, Latest HeadlinesTweet-
Analysis: Most research on PFAS harms is unpublicized https://t.co/4MyAv0dgoC https://t.co/8KzShvMFG4
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Mashup Score: 0A curated benchmark of enhancer-gene interactions for evaluating enhancer-target gene prediction methods - Genome Biology - 1 year(s) ago
Background Many genome-wide collections of candidate cis-regulatory elements (cCREs) have been defined using genomic and epigenomic data, but it remains a major challenge to connect these elements to their target genes. Results To facilitate the development of computational methods for predicting target genes, we develop a Benchmark of candidate Enhancer-Gene Interactions (BENGI) by integrating…
Source: BioMed CentralCategories: Healthcare Professionals, Latest HeadlinesTweet-
RT @DianaFerroBio: @ProfTimothyCox Maybe this could help? https://t.co/bydJDqsWEN
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Mashup Score: 0
Background To determine if neighborhood socioeconomic deprivation independently predicts 30-day mortality and readmission for patients with sepsis or critical illness after adjusting for individual poverty, demographics, comorbidity burden, access to healthcare, and characteristics of treating healthcare facilities. Methods We performed a nationwide study of United States Medicare beneficiaries…
Source: BioMed CentralCategories: Latest Headlines, PulmonologyTweet-
#Neighborhood #socioeconomic #deprivation, healthcare access, and 30-day #mortality and readmission after sepsis or #critical #illness: findings from a nationwide study https://t.co/uyY8cRiwO3 https://t.co/U9VAhmtuom
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Mashup Score: 0
Background With the growing availability of cannabis and the popularization of additional routes of cannabis use beyond smoking, including edibles, the prevalence of cannabis use in pregnancy is rapidly increasing. However, the potential effects of prenatal cannabis use on fetal developmental programming remain unknown. Results We designed this study to determine whether the use of edible…
Source: BioMed CentralCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A study published in Clinical Epigenetics finds that prenatal THC exposure alters placental and fetal DNA methylation at genes involved in neurobehavioral development that may influence longer-term offspring outcomes. https://t.co/9UuSiFlLIo
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A study in Cardiovascular Diabetology finds that type 2 diabetes is associated with a higher risk of all-cause mortality in middle-aged and elderly inpatients with heart failure in Switzerland. Chronic kidney disease may further increase this risk. https://t.co/4whupX558a