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Mashup Score: 1Unravelling the hidden side of laundry: malodour, microbiome and pathogenome - BMC Biology - 4 day(s) ago
Background Recent trends towards lower washing temperatures and a reduction in the use of bleaching agents in laundry undoubtedly benefit our environment. However, these conditions impair microbial removal on clothes, leading to malodour generation and negative impacts on consumer well-being. Clothing undergoes cycles of wearing, washing and drying, with variable exposure to microorganisms and volatilomes originating from the skin, washing machine, water and laundry products. Laundry malodour is therefore a complex problem that reflects its dynamic ecosystem. To date, comprehensive investigations that encompass the evaluation of both microbial community and malodorous volatile organic compounds throughout all stages of the wash-wear-dry cycle are scarce. Furthermore, the microbial and malodour profiles associated with extended humid-drying conditions are poorly defined. Results Here we present olfaction-directed chemical and microbiological studies of synthetic T-shirts after wearing,
Source: bmcbiol.biomedcentral.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1Prediction models for treatment response in migraine: a systematic review and meta-analysis - The Journal of Headache and Pain - 4 day(s) ago
Background Migraine is a complex neurological disorder with significant clinical variability, posing challenges for effective management. Multiple treatments are available for migraine, but individual responses vary widely, making accurate prediction crucial for personalized care. This study aims to examine the use of statistical and machine learning models to predict treatment response in migraine patients. Methods A systematic review and meta-analysis were conducted to assess the performance and quality of predictive models for migraine treatment response. Relevant studies were identified from databases such as PubMed, Cochrane Register of Controlled Trials, Embase, and Web of Science, up to 30th of November 2024. The risk of bias was evaluated using the PROBAST tool, and adherence to reporting standards was assessed with the TRIPOD + AI checklist. Results After screening 1,927 documents, ten studies met the inclusion criteria, and six were included in a quantitative synthesis. Key d
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A Review published in the Journal of Headache and Pain highlights the potential of statistical and machine learning models in predicting treatment response in migraine patients. https://t.co/H1xsxnvnZi
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Mashup Score: 1
Background & aims Sarcopenia, characterized by the loss of muscle mass and strength, is a significant concern in cirrhotic patients. Nutritional interventions have been explored for its management, but the comparative efficacy of these interventions remains unclear. This study synthesizes current evidence to evaluate the effectiveness of nutritional interventions for sarcopenia in cirrhosis. Methods Data sources included Scopus, PubMed, Web of Science Core Collection, and Cochrane Library up to Dec 2024. Eligible trials compared different nutritional interventions against control diets, placebos, or each other. A Bayesian network meta-analysis was performed to combine direct and indirect evidence. Effect sizes were calculated as mean differences (MD) with 95% confidence intervals (CIs). Intervention rankings were assessed using P-score, and evidence quality was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Results A total of 1
Source: bmcnutr.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
A systematic review and meta-analysis published in #BMCNutr finds that for sarcopenia in patients with cirrhosis, the most effective dietary intervention is post-paracentesis intravenous nutritional support combined with an oral nutritional protocol. https://t.co/PuBjrgAMoL
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Mashup Score: 0Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity - Critical Care - 8 day(s) ago
Background Traumatic brain injury (TBI) is a major public health concern worldwide, contributing to high rates of injury-related death and disability. Severe traumatic brain injury (sTBI), although it accounts for only 10% of all TBI cases, results in a mortality rate of 30–40% and a significant burden of disability in those that survive. This study explored the potential of metabolomics in the diagnosis of sTBI and explored the potential of metabolomics to examine probable primary and secondary brain injury in sTBI. Methods Serum samples from 59 adult patients with sTBI and 35 age- and sex-matched orthopedic injury controls were subjected to quantitative metabolomics, including proton nuclear magnetic resonance (1H-NMR) and direct infusion/liquid chromatography-tandem mass spectrometry (DI/LC–MS/MS), to identify and quantify metabolites on days 1 and 4 post-injury. In addition, we used advanced analytical methods to discover metabo-patterns associated with sTBI diagnosis and those rel
Source: ccforum.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
A study in @Crit_Care finds that serum metabolomics has diagnostic potential for severe traumatic brain injury and may reflect molecular mechanisms of primary and secondary brain injuries. https://t.co/1a75R9cbIW
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Mashup Score: 1Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review - BMC Medicine - 8 day(s) ago
Background Pain is a major challenge for patients with rheumatoid arthritis (RA), with many people suffering chronic pain. Current RA management guidelines focus on assessing and reducing disease activity using disease-modifying anti-rheumatic drugs (DMARDs). Consequently, pain care is often suboptimal, with growing evidence that analgesics are widely prescribed to patients with RA, despite potential toxicities and limited evidence for efficacy. Our review provides an overview of pharmacological treatments for pain in patients with RA, summarising their efficacy and use. Findings Thirteen systematic reviews of drug efficacy for pain in patients with RA were included in this review. These showed moderate- to high-quality evidence from clinical trials in more contemporary time-periods (mainly 1990s/2000s for synthetic DMARDs and post-2000 for biological/targeted synthetic DMARDs) that, in patients with active RA, short-term glucocorticoids and synthetic, biologic, and targeted synthetic
Source: bmcmedicine.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
A Review published in @BMCMedicine provides an overview of pharmacological treatments for pain in patients with rheumatoid arthritis, summarising their efficacy and use. https://t.co/lAsdCGE4Pe
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Mashup Score: 2
Background Prior studies on the link between socioeconomic status (SES) and diabetic microvascular complications have been inconclusive. This study aimed to explore whether SES is associated with the risk of diabetic retinopathy (DR), nephropathy (DN) and diabetic peripheral neuropathy (DPN) using large prospective cohort. Methods SES was evaluated using education attainment (individual level), household income (household level), and Townsend deprivation index (TDI, neighborhood level). This study included 28,339 participants without DR, 29,951 without DN and 29,762 without DPN at baseline from the UK Biobank. Weighted Cox proportional hazard models were used to investigate the relationship between SES and the risk of diabetic microvascular complications. Results The median follow-ups of the DR, DN and DPN cohorts were 12.95, 12.89 and 13.02 years, respectively. In total, 3,177 (11.2%) participants developed DR, 4,418 (14.8%) developed DN and 1,604 (5.4%) developed DPN. After adjusting
Source: dmsjournal.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
Low socio-economic status significantly increases the risk of incident diabetic retinopathy, diabetic nephropathy and diabetic peripheral neuropathy, finds a study published in Diabetology & Metabolic Syndrome. https://t.co/OjpE3UyQEU
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Mashup Score: 0
Background Guidelines recognized dual combination in initial antihypertensive therapy. Studies found that low-dose quadruple combination were superior to monotherapy. However, whether low-dose quadruple therapy is better than dual combination is unknown. Methods A randomized blinded crossover trial was conducted to compare the efficacy and safety of low-dose quadruple antihypertensives (irbesartan 75 mg + metoprolol 23.75 mg + amlodipine 2.5 mg + indapamide 1.25 mg) with standard-dose dual antihypertensives (irbesartan 150 mg + amlodipine 5 mg), both in a single pill, in the initial treatment of patients with mild to moderate hypertension. Patients were randomly assigned in a 1:1 ratio to two crossover sequences. Each sequence received four-weeks of either half-dose quadruple antihypertensives or standard-dose dual antihypertensives, followed by a two-week washout and crossover for four-weeks. Participants and researchers were blinded. The main outcomes were the reduction of blood pres
Source: bmcmedicine.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
A study published in @BMCMedicine finds that in hypertensive patients, initiating treatment with half-dose quadruple combination therapy is more effective in lowering blood pressure than standard-dose dual therapy. https://t.co/10elS1Gk2T
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Mashup Score: 0Association of workforce participation with depression among US older adults: results from NHANES 2005–2018 - BMC Geriatrics - 9 day(s) ago
Background The challenges of global aging would boost more workforce participation of older adults, and depression rate was increasing among older adults. This study aimed to explore the associations of workforce participation with depression among US older adults. Methods This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) 2005–2018. Depression was measured with Patient Health Questionnaire-9 items (PHQ-9). Workforce participation was measured with work status, work types, shift work, and hours worked per week. Multivariate generalised linear and logistic regression models, also with restricted cubic spline (RCS) were performed to examine linear or non-linear associations between workforce participation and depression. Analyses of subgroup and sensitivity were conducted: using data from non-multiple imputation, participants aged over 65, and all non-excluded participants aged 60 or above to execute repeated analysis; recruiting prope
Source: bmcgeriatr.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
Regular daytime working is positively related to decreased depression risk among US older adults, and the suggested optimal working hours are 25 to 35 per week, reports a study published in #BMCGeriatr https://t.co/bNIBohs5EV
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Mashup Score: 2
Background Maternal glucose and lipid levels are known to influence fetal growth. However, data on how maternal lipid profiles affect birth size in women with gestational diabetes (GDM) compared with those without GDM are scarce. Methods This retrospective study included 10,490 women with singleton pregnancies (2351 with GDM and 8139 without GDM) between December 2016 and July 2022. Maternal serum levels of total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol were measured at 28–42 weeks of gestation. Maternal glucose levels were determined using the 2-h oral glucose tolerance test. The neonatal birth weight was obtained at delivery and standardized as the birth weight z score according to the INTERGROWTH-21st standards. Results Compared with women without GDM, those with GDM presented increased mean TG levels and decreased levels of TC, HDL cholesterol, and LDL cholesterol. TG levels were positively asso
Source: lipidworld.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
A study published in Lipids in Health and Disease provides evidence of a significant association between maternal lipid levels during late pregnancy and offspring birth size. https://t.co/03Zxi42j1O
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Mashup Score: 4Does preeclampsia impact the gut microbiota of preterm offspring during early infancy? - Journal of Translational Medicine - 9 day(s) ago
Preeclampsia (PE) is a pregnancy complication characterized by high blood pressure and organ damage. This study investigates the differences in the gut microbiota between preterm neonates born to mothers with PE and those born to mothers without PE (PR), aiming to understand how maternal health conditions like PE influence neonatal gut microbiota. The early gut microbiota plays a crucial role in neonatal health, and disturbances in its development can have long-term consequences. Fecal samples were collected from preterm neonates of PE and PR mothers at 2 and 6 weeks postpartum and analyzed using shotgun metagenomic sequencing. We found that PE significantly affected the gut microbial composition of preterm neonates, particularly at 2 weeks postpartum. The gut microbial diversity in the PE_2 group was notably lower compared to the PR_2 group, with no significant difference observed between the PR_6 and PE_6 groups. At the phylum level, Firmicutes and Proteobacteria were predominant, wi
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A study published in the Journal of Translational Medicine underscores the substantial influence of maternal health on the early development of the neonatal gut microbiota and highlights the potential long-term health consequences. https://t.co/5ixxIrQx7P
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A study in @BMCBiology discusses the exchange of specific bacteria during washing and implies that both worn and unworn clothing acquire a “washing” microbiome. The paper suggests development of next-generation laundry products for consumer well-being. https://t.co/gAzG3k6g0y