-
Mashup Score: 36Germline Testing identifies Pathogenic/Likely Pathogenic Variants in Patients with Pancreatic Neuroendocrine Tumors - 6 day(s) ago
Abstract. 10% of pancreatic neuroendocrine tumors (pNETs) are related to inherited syndromes (MEN1, MEN4, VHL, NF1, TSC). Growing evidence suggests that clinically sporadic pNETs can also harbor germline pathogenic variants. In this study, we report the prevalence of pathological/likely pathological germline variants (P/LP) in a high-risk cohort and an unselected cohort. We collected clinical data of patients with pNETs seen at MD Anderson Cancer Center (MDACC) and Johns Hopkins Hospital (JHH). High-risk cohort included (n=132) patients seen at MDACC who underwent germline testing for high-risk criteria (early onset, personal or family history of cancer and syndromic features) between 2013-2019. Unselected cohort (n=106) patients seen at JHH who underwent germline testing following their diagnosis of pNETs between 2020 to 2022. In the high-risk cohort (n=132), 33% (n=44) had P/LP variants. The majority of the patients had P/LP variants in MEN1 56% (n=25), followed by DNA repair pathway
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 30
Abstract. Pancreatic cancer prevalence increases with age, and disease prognosis is poorer in older individuals. The increased prevalence is driven, undoubtedly, by the multistep accumulation of oncogenic mutations in cancer cells with age. However, fibroblasts are major constituents and key players in pancreatic cancer, and they too undergo age-related changes that may contribute to disease severity. In this issue of Cancer Research, Zabransky and colleagues set out to dissect the effect of age-related changes in pancreatic fibroblasts on pancreatic ductal adenocarcinoma growth and metastasis. They discovered that aged fibroblasts secrete GDF-15, which in turn activates AKT signaling and accelerates tumor progression. These findings provide a mechanistic role for aged fibroblasts in pancreatic cancer, underpinning the importance of normal physiologic processes in tumor progression.See related article by Zabransky et al., p. 1221
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 1Effect of surgery versus chemotherapy in pancreatic cancer patients: a target trial emulation - 8 day(s) ago
AbstractBackground. To estimate the causal effect of surgery vs chemotherapy on survival in patients with T1-3NxM0 pancreatic cancer in a rigorous framewor
Source: academic.oup.comCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 93Transcriptomic-Based Microenvironment Classification Reveals Precision Medicine Strategies for Pancreatic Ductal Adenocarcinoma - 9 day(s) ago
Transcriptomic-based tumor microenvironment classification identifies 4 prognostically distinct pancreatic ductal adenocarcinoma subtypes that can serve as a framework for patient selection to precision medicine trials.
Source: www.gastrojournal.orgCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 4
The International Journal of Cancer is a cancer journal from the Union for International Cancer Control covering experimental and clinical cancer research.
Source: onlinelibrary.wiley.comCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 0
Researchers develop signature for pancreatic cancer based on microRNAs and cell-free DNA markers in the blood of patients with the disease.
Source: www.mdedge.comCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 1Patrick Swayze’s Widow Reflects His Cancer, Demi Moore Speaks About Breast Cancer and More - 19 day(s) ago
From Patrick Swayze’s widow recalling his pancreatic cancer diagnosis to Demi Moore speaking about her aunt’s courage during cancer, here’s what’s going on in the oncology space this week.
Source: www.curetoday.comCategories: General Medicine News, NursingTweet
-
Mashup Score: 125The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia - 20 day(s) ago
Liu et al. identify a novel feedforward loop between tumor cells and macrophages that promotes muscle wasting. Specifically, tumor-derived CCL2 activates macrophages to facilitate non-autonomous activation of TWEAK in tumor cells via CCL5/p65 signaling, leading to cachexia. Macrophage depletion and TWEAK inhibition represent promising therapeutic targets for pancreatic cancer cachexia.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 84Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions - 21 day(s) ago
Communications Biology – Pancreatic cancer-associated fibroblast enhance the expression of sialic acidcontaining glycans, which interact with Siglec7, -9, -10, -15 receptors on myeloid cells, and…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 0CAN-2409 May Improve Survival in Pancreatic Cancer - 21 day(s) ago
CAN-2409 has been associated with improved survival among patients with non-metastatic, borderline resectable pancreatic ductal adenocarcinoma.
Source: www.curetoday.comCategories: General Medicine News, NursingTweet
In @CAPR_AACR from @hopkinskimmel & @MDAndersonNews #PancreaticCancer teams: Germline Testing identifies Pathogenic/Likely Pathogenic Variants in Patients with Pancreatic Neuroendocrine Tumors https://t.co/PPLsGC8wT4 In an unselected population, 1 in 5 harbor germline alterations… https://t.co/nb8IGxwIbU