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Background Extubation failure is an important issue in ventilated patients and its risk factors remain a matter of research. We conducted a systematic review...

Critical Care volume 25, Article number: 389 (2021) Cite this article...

Background Timely recognition of hemodynamic instability in critically ill patients enables increased vigilance and early treatment opportunities. We develop the Hemodynamic Stability Index (HSI),...

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BMJ is a champion of open access as a way to promote knowledge and accelerate discoveries. We place a great deal of importance on...

Mechanical ventilators display detailed waveforms which contain a wealth of clinically relevant information. Although much has been written about interpretation of waveforms and patient-ventilator...

Background and Purpose: Randomized patent foramen ovale closure trials have used open-label end point ascertainment which increases the risk of bias and undermines confidence...

The aim of this study was to assess the impact of age of 80 years or older on the creation of anastomoses, the risk of...

Background and Purpose: Optimal blood pressure (BP) management in the acute phase of ischemic stroke remains an unresolved issue. It is uncertain whether guidelines...

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The causal relationship between DNA demethylation and gene expression regulation has not yet been fully resolved. Here the authors develop a nuclease-dead Cas9 (dCas9)...