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Mashup Score: 2A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation - 1 hour(s) ago
Upregulation of a cluster of primate-specific KRAB zinc finger proteins in cancer cells prevents replicative stress and inflammation by regulating heterochromatin maintenance, which could facilitate the development of improved biomarkers and treatments.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3
Abstract. Activation of effector T cells leads to upregulation of PD-1, which can inhibit T-cell activity following engagement with its ligand PD-L1. Post-translational modifications (PTM), including glycosylation, phosphorylation, ubiquitination, and palmitoylation, play a significant role in regulating PD-1 protein stability, localization, and interprotein interactions. Targeting PTM of PD-1 in T cells has emerged as a potential strategy to overcome PD-1–mediated immunosuppression in cancer and enhances antitumor immunity. The regulatory signaling pathways that induce PTM of PD-1 can be suppressed with small-molecule inhibitors, and mAbs can directly target PD-1 PTMs. Preliminary outcomes from exploratory studies suggest that focusing on the PTM of PD-1 has strong therapeutic potential and can enhance the response to anti-PD-1.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 14
Remote monitoring (RM) is recommended to follow patients with implantable cardioverter defibrillators (ICDs).1 RM enables early detection of critical conditions and reduces in-clinic evaluations. However, adoption lags. An acknowledged barrier is insufficient personnel, linked to insufficient reimbursement, to conduct the “invisible” clinic work associated with virtual care (e.g., triaging alerts, documentation, patient communication and scheduling).2 This encourages a re-examination of the RM schedule and cost/reimbursement structure.
Source: www.heartrhythmjournal.comCategories: General Medicine News, Cardiology News and JournTweet
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Mashup Score: 0
Loading oral sotalol for atrial fibrillation (AF) requires 3 days, frequently in-hospital, to achieve steady state. The FDA approved loading with intravenous (IV) sotalol through model-informed development, without patient data.
Source: www.heartrhythmjournal.comCategories: General Medicine News, Cardiology News and JournTweet
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Mashup Score: 17ECG-only Explainable Deep Learning Algorithm Predicts the Risk for Malignant Ventricular Arrhythmia in Phospholamban Cardiomyopathy - 2 day(s) ago
Phospholamban (PLN) p.(Arg14del) variant carriers are at risk of developing malignant ventricular arrhythmias (MVA). Accurate risk stratification allows for timely implantation of intracardiac defibrillators (ICD) and is currently performed using a multimodality prediction model.
Source: www.heartrhythmjournal.comCategories: General Medicine News, Cardiology News and JournTweet
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Mashup Score: 26Deep Learning Model for Tumor Type Prediction using Targeted Clinical Genomic Sequencing Data - 3 day(s) ago
Abstract. Tumor type guides clinical treatment decisions in cancer, but histology-based diagnosis remains challenging. Genomic alterations are highly diagnostic of tumor type, and tumor type classifiers trained on genomic features have been explored, but the most accurate methods are not clinically feasible, relying on features derived from whole genome sequencing (WGS), or predicting across limited cancer types. We use genomic features from a dataset of 39,787 solid tumors sequenced using a clinical targeted cancer gene panel to develop Genome-Derived-Diagnosis Ensemble (GDD-ENS): a hyperparameter ensemble for classifying tumor type using deep neural networks. GDD-ENS achieves 93% accuracy for high-confidence predictions across 38 cancer types, rivalling performance of WGS-based methods. GDD-ENS can also guide diagnoses on rare type and cancers of unknown primary, and incorporate patient-specific clinical information for improved predictions. Overall, integrating GDD-ENS into prospect
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 21Changes in Natriuretic Peptide Levels and Subsequent Kidney Function Decline in the SPRINT Trial - 3 day(s) ago
Novel approaches to assessing kidney disease risk during hypertension treatment are needed given the uncertainty in how intensive blood pressure (BP) lowering impacts kidney outcomes. We determined whether longitudinal N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurements during hypertension treatment are associated with kidney function decline.
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet
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Mashup Score: 21Changes in Natriuretic Peptide Levels and Subsequent Kidney Function Decline in the SPRINT Trial - 3 day(s) ago
Novel approaches to assessing kidney disease risk during hypertension treatment are needed given the uncertainty in how intensive blood pressure (BP) lowering impacts kidney outcomes. We determined whether longitudinal N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurements during hypertension treatment are associated with kidney function decline.
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet
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Mashup Score: 6
Cancer is an international interdisciplinary journal publishing articles on the latest clinical cancer research findings, spanning the breadth of oncology disciplines.
Categories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0Efficacy of non-pharmacological interventions for primary dysmenorrhoea: a systematic review and Bayesian network meta-analysis - 4 day(s) ago
Objectives To assess the relative benefits of various non-pharmacological interventions on treating primary dysmenorrhoea within a network meta-analysis. Study design Systematic review and Bayesian network meta-analysis. Inclusion criteria Randomised controlled trial involving patient with primary dysmenorrhoea and received non-pharmacological interventions. Data sources Four databases (Medline, Embase, Cochrane Library and Web of Science) were searched from inception to October first, 2022. Risk-of-bias (RoB) assessment RoB 2.0 assessment tools was used to assess the risk of bias in the included studies. Synthesis of results Conventional meta-analysis was conducted by pairwise comparison between non-pharmacological therapy and control treatment. The Bayesian network meta-analysis was conducted by the Aggregate Data Drug Information System Software based on the consistency or inconsistency model, and rank probability was used to indicate the priority of non-pharmacological therapy. Res
Source: ebm.bmj.comCategories: General Medicine News, PayerTweet
The new cover of @CR_AACR is gorgeous! Read the description, related to this #OpenAccess cover article: A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation https://t.co/DCqDJuBexQ https://t.co/9zekqy40O2