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Mashup Score: 1Rapid reviews methods series: assessing the appropriateness of conducting a rapid review - 2 hour(s) ago
This paper, part of the Cochrane Rapid Review Methods Group series, offers guidance on determining when to conduct a rapid review (RR) instead of a full systematic review (SR). While both review types aim to comprehensively synthesise evidence, RRs, conducted within a shorter time frame of typically 6 months or less, involve streamlined methods to expedite the process. The decision to opt for an RR depends on the urgency of the research question, resource availability and the impact on decision outcomes. The paper categorises scenarios where RRs are appropriate, including urgent decision-making, informing guidelines, assessing new technologies and identifying evidence gaps. It also outlines instances when RRs may be inappropriate, cautioning against conducting them solely for ease, quick publication or only cost-saving motives. When deciding on an RR, it is crucial to consider both conceptual and practical factors. These factors encompass the urgency of needing timely evidence, the con
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Mashup Score: 3CARE-radiology statement explanation and elaboration: reporting guideline for radiological case reports - 12 hour(s) ago
Despite the increasing number of radiological case reports, the majority lack a standardised methodology of writing and reporting. We therefore develop a reporting guideline for radiological case reports based on the CAse REport (CARE) statement. We established a multidisciplinary group of experts, comprising 40 radiologists, methodologists, journal editors and researchers, to develop a reporting guideline for radiological case reports according to the methodology recommended by the Enhancing the QUAlity and Transparency Of health Research network. The Delphi panel was requested to evaluate the significance of a list of elements for potential inclusion in a guideline for reporting mediation analyses. By reviewing the reporting guidelines and through discussion, we initially drafted 46 potential items. Following a Delphi survey and discussion, the final CARE-radiology checklist is comprised of 38 items in 16 domains. CARE-radiology is a comprehensive reporting guideline for radiological
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Mashup Score: 25Reporting health and medical research - 1 day(s) ago
The use of the best available evidence to inform patient care in evidence-based medicine is reliant on the accurate, complete and transparent reporting of health and medical research. Without a complete and transparent account of what was done and what was found during a research study, findings cannot be fully understood, replicated, assessed for validity and applicability, and used to inform clinical and policy decisions. For over 50 years, problems of incomplete and poor reporting of research have been widely documented across health and medical research.1–3 Unusable research reports contribute to avoidable research waste4 through the inability to appraise and synthesise research and can detrimentally impact patient care through incorrect implementation of research findings.5 Because of this, complete and transparent reporting of research is a researcher’s moral and ethical responsibility to maximise the usefulness and positive impact of their research.6 Our objective in this articl
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Mashup Score: 955Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies - 2 day(s) ago
Objective To investigate the associations across genetic and lifestyle factors with lifespan. Design A longitudinal cohort study. Setting UK Biobank. Participants 353 742 adults of European ancestry, who were recruited from 2006 to 2010 and were followed up until 2021. Exposures A polygenic risk score for lifespan with long (highest quintile) risk categories and a weighted healthy lifestyle score, including no current smoking, moderate alcohol consumption, regular physical activity, healthy body shape, adequate sleep duration, and a healthy diet, categorised into favourable, intermediate, and unfavourable lifestyles. Main outcome measures Lifespan defined as the date of death or the censor date minus the date of birth. Results Of the included 353 742 participants of European ancestry with a median follow-up of 12.86 years, 24 239 death cases were identified. Participants were grouped into three genetically determined lifespan categories including long (20.1%), intermediate (60.1%), and
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Mashup Score: 955Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies - 2 day(s) ago
Objective To investigate the associations across genetic and lifestyle factors with lifespan. Design A longitudinal cohort study. Setting UK Biobank. Participants 353 742 adults of European ancestry, who were recruited from 2006 to 2010 and were followed up until 2021. Exposures A polygenic risk score for lifespan with long (highest quintile) risk categories and a weighted healthy lifestyle score, including no current smoking, moderate alcohol consumption, regular physical activity, healthy body shape, adequate sleep duration, and a healthy diet, categorised into favourable, intermediate, and unfavourable lifestyles. Main outcome measures Lifespan defined as the date of death or the censor date minus the date of birth. Results Of the included 353 742 participants of European ancestry with a median follow-up of 12.86 years, 24 239 death cases were identified. Participants were grouped into three genetically determined lifespan categories including long (20.1%), intermediate (60.1%), and
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Mashup Score: 955Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies - 2 day(s) ago
Objective To investigate the associations across genetic and lifestyle factors with lifespan. Design A longitudinal cohort study. Setting UK Biobank. Participants 353 742 adults of European ancestry, who were recruited from 2006 to 2010 and were followed up until 2021. Exposures A polygenic risk score for lifespan with long (highest quintile) risk categories and a weighted healthy lifestyle score, including no current smoking, moderate alcohol consumption, regular physical activity, healthy body shape, adequate sleep duration, and a healthy diet, categorised into favourable, intermediate, and unfavourable lifestyles. Main outcome measures Lifespan defined as the date of death or the censor date minus the date of birth. Results Of the included 353 742 participants of European ancestry with a median follow-up of 12.86 years, 24 239 death cases were identified. Participants were grouped into three genetically determined lifespan categories including long (20.1%), intermediate (60.1%), and
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Mashup Score: 5
My friend Dorothy (a pseudonym) is in her mid-40s. She loves parties and sharing good food with family and friends. She likes watching musicals and films, going to the ballet and the pantomime, to the pub and to church as well as expressing herself creatively. Whatever she is doing, she enjoys looking stylish and receiving compliments about her appearance. It has not been possible for Dorothy to have a thorough dental examination in her adult life, nor blood pressure checks, women’s health checks or any other preventative health checks. Why? Because she has a severe intellectual disability, and there are few services that provide the adjustments she would need to access preventative healthcare. It is also not possible for her to share her story because she has few clear words, and so I, a friend and former member of her care team, have worked with members of her family to write on her behalf. Dorothy is very wary of unfamiliar situations and people and often finds transitions hard. She
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Mashup Score: 12
This paper forms part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group and addresses rapid qualitative evidence syntheses (QESs), which use modified systematic, transparent and reproducible methodsu to accelerate the synthesis of qualitative evidence when faced with resource constraints. This guidance covers the review process as it relates to synthesis of qualitative research. ‘Rapid’ or ‘resource-constrained’ QES require use of templates and targeted knowledge user involvement. Clear definition of perspectives and decisions on indirect evidence, sampling and use of existing QES help in targeting eligibility criteria. Involvement of an information specialist, especially in prioritising databases, targeting grey literature and planning supplemental searches, can prove invaluable. Use of templates and frameworks in study selection and data extraction can be accompanied by quality assurance procedures targeting areas of likely weakness. Current Cochran
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Mashup Score: 25Reporting health and medical research - 6 day(s) ago
The use of the best available evidence to inform patient care in evidence-based medicine is reliant on the accurate, complete and transparent reporting of health and medical research. Without a complete and transparent account of what was done and what was found during a research study, findings cannot be fully understood, replicated, assessed for validity and applicability, and used to inform clinical and policy decisions. For over 50 years, problems of incomplete and poor reporting of research have been widely documented across health and medical research.1–3 Unusable research reports contribute to avoidable research waste4 through the inability to appraise and synthesise research and can detrimentally impact patient care through incorrect implementation of research findings.5 Because of this, complete and transparent reporting of research is a researcher’s moral and ethical responsibility to maximise the usefulness and positive impact of their research.6 Our objective in this articl
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Mashup Score: 24Overly complex methods may impair pragmatic use of core evidence-based medicine principles - 6 day(s) ago
The aphorism suggesting that we should keep things as simple as possible but not simpler applies well to the world of evidence-based medicine (EBM). The initial Users’ Guide to the Medical Literature that launched the era of EBM adhered faithfully to the as-simple-as-possible rule. For instance, the first Users’ Guide to therapy published in JAMA in 1993 presenting appraisal guidance for studies of interventions offered only two primary and two secondary validity (now risk of bias) criteria and was little more than three pages in length.1 The guides that followed adhered to the same parsimonious presentations, short and with few criteria. That simplicity in part explains EBM’s extraordinarily rapid and extensive uptake, with the Users’ Guides series and subsequently the associated textbook2 widely adopted in undergraduate and postgraduate medical programmes in a matter of just a few years. Following the initial focus on critical appraisal for clinicians, EBM leaders became aware that f
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Rapid reviews methods series: assessing the appropriateness of conducting a rapid review Research methods and reporting by @cgarritty @decdevane et al. @CochraneRRMG #OpenAccess Link: https://t.co/ZTFSH0uulw https://t.co/SHcbjoc6w5