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    The tocopherol transfer protein mediates vitamin E trafficking between cerebellar astrocytes and neurons - 2 year(s) ago

    Alpha-tocopherol (vitamin E) is an essential nutrient that functions as a major lipid-soluble antioxidant in humans. The alpha-tocopherol transfer protein (TTP) binds α-tocopherol with high affinity and selectivity and regulates whole-body distribution of the vitamin. Heritable mutations in the TTPA gene result in familial vitamin E deficiency, elevated indices of oxidative stress, and…

    Source: Journal of Biological Chemistry
    Categories: Latest Headlines, Neurology
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      ELSneuroscience

      Ulatowski et al.'s data indicate that TTP-expressing astrocytes control the delivery of #vitaminE from astrocytes to neurons, and that this process is homeostatically responsive to oxidative stress — @caseccc @CWRUSOM @UrsulineCampus #neurodegeneration https://t.co/bfq2CUg78U

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    TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice - 2 year(s) ago

    Author summary Polyglutamylation is a process that modifies proteins with a degradable side chain of glutamate residues. The enzymes that catalyze the addition and removal of the side chain are tubulin tyrosine ligase like (TTLL) members and 6-member cytosolic carboxypeptidase (CCP) family, respectively. Mutations of Nna1/CCP1 cause severe neurodegeneration across species, including human, while…

    Source: journals.plos.org
    Categories: Genetics, Latest Headlines
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      PLOSGenetics

      New #neurodegeneration research: Wu et al find that Ttll1 deficiency rescues Purkinje cell loss & olfactory bulb mitral cells and retinal photoreceptors #InMice TTLL4 loss partially rescues photoreceptor degeneration 🔎: https://t.co/L90vUrZLSw @DnbResearch @StJudeResearch https://t.co/VjFCtuphsq

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    Online Event - 2 year(s) ago

    Check this box to agree to receive occasional email or other contact from the sponsor of this webinar about their programs, products, services and other offerings. The sponsor agrees not to rent, sell, exchange, or give your information to any third party without permission. You may opt out of these emails at any time by contacting the sponsor. Check this box to agree to receive…

    Source: view6.workcast.net
    Categories: Future of Medicine, Latest Headlines
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      ScienceMagazine

      It's not too late—join #ScienceWebinars for Storm chasing: #Cytokine profiling via flow cytometry in age-related neurodegenerative diseases. Register today for the event live on 8 June at 12 p.m. ET: https://t.co/FPKqDA3M8p #Neurodegeneration #Webinar https://t.co/B9Df7QiDuM

  • Mashup Score: 19
    Online Event - 2 year(s) ago

    Check this box to agree to receive occasional email or other contact from the sponsor of this webinar about their programs, products, services and other offerings. The sponsor agrees not to rent, sell, exchange, or give your information to any third party without permission. You may opt out of these emails at any time by contacting the sponsor. Check this box to agree to receive…

    Source: view6.workcast.net
    Categories: Future of Medicine, Latest Headlines
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      ScienceMagazine

      On 8 June at 12 p.m. ET, join #ScienceWebinars for ➡ Storm chasing: #Cytokine profiling via flow cytometry in age-related neurodegenerative diseases. Register today: https://t.co/gfAloKEA8W #Neurodegeneration #Webinar https://t.co/bFmNXMGdDX

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    Conferences | Keystone Symposia - 2 year(s) ago

    Privacy Policy Terms of Use © 2022 Keystone Symposia on Molecular and Cellular Biology

    Source: www.keystonesymposia.org
    Categories: General Medicine News, Latest Headlines
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      NatureComms

      Our editor Sophie Morgan will be attending the Neurodegeneration/Neuro-immune Interactions @KeystoneSymp next week! Livestream/On Demand access is also available https://t.co/xptOCfa8r7 #KSNeuroImmune22 #KSNeurodegen22 #Neurodegeneration #neuroinflammation https://t.co/3Te8iBE76u

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    Redesigning therapies for pantothenate kinase–associated neurodegeneration - 2 year(s) ago

    Pantothenate kinase–associated neurodegeneration (PKAN) is an incurable rare genetic disorder of children and young adults caused by mutations in the PANK2 gene, which encodes an enzyme critical for the biosynthesis of coenzyme A. Although PKAN affects only a small number of patients, it shares several hallmarks of more common neurodegenerative diseases of older adults such as Alzheimer’s disease…

    Source: Journal of Biological Chemistry
    Categories: Latest Headlines, Neurology
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    • Profile photo of ELSneuroscience
      ELSneuroscience

      #JBCReviews | Redesigning therapies for pantothenate kinase-associated #neurodegeneration | Munshi et al. summarize their knowledge of #PKAN and demonstrate how it forms the backdrop to new avenues of research — @YaleMed #neuro #genetherapy https://t.co/m4NIAreRl8

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    Aging is associated with increased brain iron through cortex-derived hepcidin expression - 2 year(s) ago

    Aging is associated with mitochondrial and cytosolic iron accumulation in the brain, which is through increased local expression of hepcidin, and subsequent iron accumulation due to decreased iron export through ferroportin-1.

    Source: eLife
    Categories: Healthcare Professionals, Latest Headlines
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      westr

      #Aging is associated with increased #brain iron through cortex-derived #hepcidin expression https://t.co/3TwclIOvqo #Iron Accumulation Linked With Age-Related #Cognitive Decline https://t.co/7F4Gozbg6r #Neurodegeneration Watch dosing, if taking supplements for #anemia..

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