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Mashup Score: 12Arrhythmias in Patients with Pulmonary Hypertension and Right Ventricular Failure: Importance of Rhythm Control Strategies - 2 month(s) ago
Arrhythmias frequently complicate the course of advanced pulmonary hypertension, often leading to hemodynamic compromise, functional impairment, and mortality. Given the importance of right atrial function in this physiology, the restoration and maintenance of sinus rhythm are of critical importance. In this review, we outline the pathophysiology of arrhythmias and their impact on right heart performance; describe considerations for antiarrhythmic drug selection, anesthetic and periprocedural management; and discuss the results of catheter ablation techniques in this complex and challenging patient population.
Source: www.mdpi.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 3Arrhythmias and Device Therapies in Cardiac Amyloidosis - 2 month(s) ago
Cardiac amyloidosis is caused by amyloid fibrils that deposit in the myocardial interstitium, causing restrictive cardiomyopathy and eventually death. The electromechanical, inflammatory, and autonomic changes due to amyloid deposition result in arrhythmias. Atrial fibrillation is by far the most common arrhythmia. The rate control strategy is generally poorly tolerated due to restrictive filling physiology and heart rate dependance, favoring adoption of the rhythm control strategy. Anticoagulation for stroke prophylaxis is warranted, irrespective of CHA2DS2-VASc score in patients with a favorable bleeding profile; data on left appendage closure devices are still insufficient. Ventricular arrhythmias are also not uncommon, and the role of implantable cardioverter-defibrillator in cardiac amyloidosis is controversial. There is no evidence of improvement in outcomes when used for primary prevention in these patients. Bradyarrhythmia is most commonly associated with sudden cardiac death i
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet-
RT @Zamrak_MD: Arrhythmias in Cardiac Amyloidosis: A review https://t.co/cIh130mZJW #mdpijcm via @JCM_MDPI @ccfvascmed @GhowebaMD @AmmarS…
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Mashup Score: 25Evolution of More Aggressive LDL-Cholesterol Targets and Therapies for Cardiovascular Disease Prevention - 5 month(s) ago
Over the last half-century, discussions on the exact targets for low-density lipoprotein cholesterol (LDL-C) reduction have evolved towards a more aggressive approach with lower LDL-C targets, particularly for high-risk patients with pre-existing atherosclerotic cardiovascular disease (ASCVD). A wealth of cardiovascular outcome trials have shown the efficacy of statin therapy in general, as well as the incremental impact of high-intensity statin therapy in particular. More recent trials have further demonstrated the impact of non-statin therapies, including ezetimibe, proprotein convertase subtilisin/kexin type 9 inhibitors, and, most recently, bempedoic acid, on reducing ASCVD outcomes. The availability of these and other newer therapies has prompted clinicians to strive for lower LDL-C targets to address residual ASCVD risk after statin therapy. This paper will provide an overview of the historical trends in lipid management and therapeutics and review the current state of evidence f
Source: www.mdpi.comCategories: General Medicine News, CardiologistsTweet-
Special thanks to our star medical student @cardioloJeff and resident Kevin Tang for their great review on Evolution of More Aggressive LDL-Cholesterol Targets and Therapies for CVD Prevention @UCI_Cardiology @UCIrvineHealth https://t.co/5hLK9Nr5Av #mdpijcm via @JCM_MDPI
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Mashup Score: 0
Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of malignancies, especially hematological tumors, but toxicities have tempered its success. The main impediments to the development of CAR-T cell therapies are the following: cytokine release syndrome (CRS), immune-effector-cell-associated neurotoxicity syndrome (ICANS), tumor lysis syndrome (TLS), and on-target/off-tumor toxicity (OTOT). This review summarizes these side effects’ underlying mechanisms and manifestations over time. It provides potential prevention and treatment according to the consensus grading, stressing the significance of establishing strategies that anticipate, reduce, and navigate the beginning of these side effects. It is essential to fully comprehend the mechanisms underlying these toxicities to create efficient treatment and preventive approaches.
Source: www.mdpi.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Exploring CAR-T Cell Therapy Side Effects: Mechanisms and Management Strategies https://t.co/5Rsa1rvzzy #mdpijcm via @JCM_MDPI #CART #bmtsm #immunotherapy #tcellrx #ICAN #CRS #CARTcells #CellTherapy #Gene #Genetherapy @ASTCT @CART_Therapy
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Mashup Score: 8Role of Cardiovascular Imaging in Risk Assessment: Recent Advances, Gaps in Evidence, and Future Directions - 8 month(s) ago
Optimal risk assessment for primary prevention remains highly challenging. Recent registries have highlighted major discrepancies between guidelines and daily practice. Although guidelines have improved over time and provide updated risk scores, they still fail to identify a significant proportion of at-risk individuals, who then miss out on effective prevention measures until their initial ischemic events. Cardiovascular imaging is progressively assuming an increasingly pivotal role, playing a crucial part in enhancing the meticulous categorization of individuals according to their risk profiles, thus enabling the customization of precise therapeutic strategies for patients with increased cardiovascular risks. For the most part, the current approach to patients with atherosclerotic cardiovascular disease (ASCVD) is homogeneous. However, data from registries (e.g., REACH, CORONOR) and randomized clinical trials (e.g., COMPASS, FOURIER, and ODYSSEY outcomes) highlight heterogeneity in t
Source: www.mdpi.comCategories: Cardiologists, Latest HeadlinesTweet-
Role of Cardiovascular Imaging in Risk Assessment: Recent Advances, Gaps in Evidence, and Future Directions https://t.co/bTlJI8t9lT #mdpijcm via @JCM_MDPI. Why don't we implement #CV imaging in practice in main EU countries ?
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Mashup Score: 0Hypertensive Heart Failure - 9 month(s) ago
Despite overwhelming epidemiological evidence, the contribution of hypertension (HTN) to heart failure (HF) development has been undermined in current clinical practice. This is because approximately half of HF patients have been labeled as suffering from HF with preserved left ventricular (LV) ejection fraction (EF) (HFpEF), with HTN, obesity, and diabetes mellitus (DM) being considered virtually equally responsible for its development. However, this suggestion is obviously inaccurate, since HTN is by far the most frequent and devastating morbidity present in HFpEF. Further, HF development in obesity or DM is rare in the absence of HTN or coronary artery disease (CAD), whereas HTN often causes HF per se. Finally, unlike HTN, for most major comorbidities present in HFpEF, including anemia, chronic kidney disease, pulmonary disease, DM, atrial fibrillation, sleep apnea, and depression, it is unknown whether they precede HF or result from it. The purpose of this paper is to provide a con
Source: www.mdpi.comCategories: Cardiologists, Latest HeadlinesTweet-
🔥🔥🔥Hypertensive Heart Failure: Lessons Learned from HFpEF https://t.co/teg9HVImHE #mdpijcm via @JCM_MDPI @filpapos
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Mashup Score: 1
Patients with ST-elevation myocardial infarction (STEMI), but without standard modifiable risk factors (SMuRF-less), are surprisingly common and appear to have a worse, or at best similar, short-term prognosis. However, relatively little attention has been paid to the prevalence and prognosis of SMuRF-less patients with non-STEMI (NSTEMI). The aim of our study was to identify the proportion and…
Source: MDPICategories: Cardiologists, Latest HeadlinesTweet-
Frequency and Outcomes of Patients Presenting with Non-ST Elevation Myocardial Infarction (NSTEMI) without Standard Modifiable Risk Factors: A US Healthcare Experience https://t.co/YHfN9y2Y1S #mdpijcm via @JCM_MDPI @Intermountain @KirkKnowlton @JBMuhlesteinMD @KnightSNPs https://t.co/zSF6NpO1KL
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Mashup Score: 0Post-Implant Phosphodiesterase-5 Inhibitors in Patients with Left Ventricular Assist Device: A Systematic Review and Meta-Analysis - 1 year(s) ago
Background: Despite the improvement in left ventricular assist device (LVAD) technology and the advent of third-generation LVADs, hemocompatibility-related events remain a significant issue. Therefore, new pharmacological treatments are necessary to optimize patient management and to further reduce hemocompatibility-related events. The purpose of the present systematic review and meta-analysis…
Source: MDPICategories: Cardiologists, Latest HeadlinesTweet-
Post-Implant Phosphodiesterase-5 Inhibitors in Patients with Left Ventricular Assist Device: A Systematic Review and Meta-Analysis https://t.co/u5w9pQIvg2 #mdpijcm via @JCM_MDPI. @rcstarling @filpapos
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Mashup Score: 0
Multimorbidity, the coexistence of multiple health conditions in an individual, has emerged as one of the greatest challenges facing health services, and this crisis is partly driven by the aging population. Aging is associated with increased aortic stiffness (AoStiff), which in turn is linked with several morbidities frequently affecting and having disastrous consequences for the elderly. These…
Source: MDPICategories: Cardiologists, Latest HeadlinesTweet-
Aortic Stiffness: A Major Risk Factor for Multimorbidity in the Elderly https://t.co/7wnaoLpCqM #mdpijcm via @JCM_MDPI 🔥🔥🔥@filpapos
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Mashup Score: 0
There is a well-documented problem of inferior outcome of muscle-invasive bladder cancer (MIBC) after radical cystectomy (RC) in women. However, previous studies were conducted before neoadjuvant chemotherapy (NAC) was widely adopted to multidisciplinary management of MIBC. In our study, we assessed the gender-related difference in survival between patients who received NAC and those who…
Source: MDPICategories: Latest Headlines, UrologyTweet-
Happy to announce our newest paper! Neoadjuvant chemotherapy helps to dminish gender-related disparity in survival among #bladdercancer patients after radical cystectomy. @bartmalkiewicz https://t.co/YkXuNc2Bvz #mdpijcm przez @JCM_MDPI
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RT @anjalivaidyaMD: ⚡️Arrhythmias in PH & RV Failure: Importance of Rhythm Control https://t.co/xF57txWQl2 #mdpijcm via @JCM_MDPI Importan…