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Mashup Score: 33Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease - 3 day(s) ago
Objective Hyperferritinaemia is associated with liver fibrosis severity in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed the role of serum ferritin in predicting long-term outcomes or death. Design We evaluated the relationship between baseline serum ferritin and longitudinal events in a multicentre cohort of 1342 patients. Four survival models considering ferritin with confounders or non-invasive scoring systems were applied with repeated five-fold cross-validation schema. Prediction performance was evaluated in terms of Harrell’s C-index and its improvement by including ferritin as a covariate. Results Median follow-up time was 96 months. Liver-related events occurred in 7.7%, hepatocellular carcinoma in 1.9%, cardiovascular events in 10.9%, extrahepatic cancers in 8.3% and all-cause mortality in 5.8%. Hyperferritinaemia was associated with a 50% increased risk of li
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 33Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease - 10 day(s) ago
Objective Hyperferritinaemia is associated with liver fibrosis severity in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed the role of serum ferritin in predicting long-term outcomes or death. Design We evaluated the relationship between baseline serum ferritin and longitudinal events in a multicentre cohort of 1342 patients. Four survival models considering ferritin with confounders or non-invasive scoring systems were applied with repeated five-fold cross-validation schema. Prediction performance was evaluated in terms of Harrell’s C-index and its improvement by including ferritin as a covariate. Results Median follow-up time was 96 months. Liver-related events occurred in 7.7%, hepatocellular carcinoma in 1.9%, cardiovascular events in 10.9%, extrahepatic cancers in 8.3% and all-cause mortality in 5.8%. Hyperferritinaemia was associated with a 50% increased risk of li
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
#GUTImages from the paper by @AngeloArmandi et al on "Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease" via https://t.co/oap3sTWjmt @DinaTiniakos @lucavalenti75 @lmiele74 @hanneshagstrom @mromerogomez https://t.co/6KG8WdxzSU
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Mashup Score: 30Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease - 17 day(s) ago
Objective Hyperferritinaemia is associated with liver fibrosis severity in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed the role of serum ferritin in predicting long-term outcomes or death. Design We evaluated the relationship between baseline serum ferritin and longitudinal events in a multicentre cohort of 1342 patients. Four survival models considering ferritin with confounders or non-invasive scoring systems were applied with repeated five-fold cross-validation schema. Prediction performance was evaluated in terms of Harrell’s C-index and its improvement by including ferritin as a covariate. Results Median follow-up time was 96 months. Liver-related events occurred in 7.7%, hepatocellular carcinoma in 1.9%, cardiovascular events in 10.9%, extrahepatic cancers in 8.3% and all-cause mortality in 5.8%. Hyperferritinaemia was associated with a 50% increased risk of li
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
#GUTImages from the paper by @AngeloArmandi et al on "Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease" via https://t.co/oap3sTWjmt @DinaTiniakos @lucavalenti75 @lmiele74 @hanneshagstrom @mromerogomez https://t.co/6KG8WdxzSU
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Mashup Score: 0Sudden onset of multiple seborrhoeic keratoses in a patient with well-differentiated neuroendocrine tumours of the gut - 10 month(s) ago
A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk (figure 1). The skin lesions started growing approximately 2 years prior. Clinical diagnosis of seborrhoeic keratoses (SK) was confirmed by histopathological examination (figure 2). Work-up of new intermittent dragging pain localised on the lower right abdominal…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 1Sudden onset of multiple seborrhoeic keratoses in a patient with well-differentiated neuroendocrine tumours of the gut - 10 month(s) ago
A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk (figure 1). The skin lesions started growing approximately 2 years prior. Clinical diagnosis of seborrhoeic keratoses (SK) was confirmed by histopathological examination (figure 2). Work-up of new intermittent dragging pain localised on the lower right abdominal…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Sudden onset of multiple seborrhoeic keratoses in a patient with well-differentiated neuroendocrine tumours of the gut - 10 month(s) ago
A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk (figure 1). The skin lesions started growing approximately 2 years prior. Clinical diagnosis of seborrhoeic keratoses (SK) was confirmed by histopathological examination (figure 2). Work-up of new intermittent dragging pain localised on the lower right abdominal…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Sudden onset of multiple seborrhoeic keratoses in a patient with well-differentiated neuroendocrine tumours of the gut - 10 month(s) ago
A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk (figure 1). The skin lesions started growing approximately 2 years prior. Clinical diagnosis of seborrhoeic keratoses (SK) was confirmed by histopathological examination (figure 2). Work-up of new intermittent dragging pain localised on the lower right abdominal…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Sudden onset of multiple seborrhoeic keratoses in a patient with well-differentiated neuroendocrine tumours of the gut - 10 month(s) ago
A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk (figure 1). The skin lesions started growing approximately 2 years prior. Clinical diagnosis of seborrhoeic keratoses (SK) was confirmed by histopathological examination (figure 2). Work-up of new intermittent dragging pain localised on the lower right abdominal…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Understanding neuroimmune interactions in disorders of gut–brain interaction: from functional to immune-mediated disorders - 1 year(s) ago
Functional gastrointestinal disorders—recently renamed into disorders of gut–brain interaction—such as irritable bowel syndrome and functional dyspepsia are highly prevalent conditions with bothersome abdominal symptoms in the absence of structural abnormalities. While traditionally considered as motility disorders or even psychosomatic conditions, our understanding of the pathophysiology has…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Understanding neuroimmune interactions in disorders of gut–brain interaction: from functional to immune-mediated disorders - 1 year(s) ago
Functional gastrointestinal disorders—recently renamed into disorders of gut–brain interaction—such as irritable bowel syndrome and functional dyspepsia are highly prevalent conditions with bothersome abdominal symptoms in the absence of structural abnormalities. While traditionally considered as motility disorders or even psychosomatic conditions, our understanding of the pathophysiology has…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
#GUTImages from the paper by @AngeloArmandi et al on "Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease" via https://t.co/oap3sTWjmt @DinaTiniakos @lucavalenti75 @lmiele74 @hanneshagstrom @mromerogomez https://t.co/6KG8WdxzSU