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Mashup Score: 0Timing of energy intake and the therapeutic potential of intermittent fasting and time-restricted eating in NAFLD - 9 month(s) ago
Non-alcoholic fatty liver disease (NAFLD) represents a major public health concern and is associated with a substantial global burden of liver-related and cardiovascular-related morbidity and mortality. High total energy intake coupled with unhealthy consumption of ultra-processed foods and saturated fats have long been regarded as major dietary drivers of NAFLD. However, there is an accumulating…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 1Biopsy and blood-based molecular biomarker of inflammation in IBD - 9 month(s) ago
Objective IBD therapies and treatments are evolving to deeper levels of remission. Molecular measures of disease may augment current endpoints including the potential for less invasive assessments. Design Transcriptome analysis on 712 endoscopically defined inflamed (Inf) and 1778 non-inflamed (Non-Inf) intestinal biopsies (n=498 Crohn’s disease, n=421 UC and 243 controls) in the Mount Sinai…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper by Argmann et al entitled "Biopsy and blood-based molecular biomarker of inflammation in IBD" via https://t.co/pA64R32Zjd #IBD #Biomarkers @JeanFredericCo1 https://t.co/NRgOqvzHLT
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Mashup Score: 0Standardisation of EUS-guided FNB technique for molecular profiling in pancreatic cancer: results of a randomised trial - 9 month(s) ago
As clinically actionable genomic lesions are found in almost 30% of pancreatic cancers that can potentially impact management, there has been increased focus on molecular profiling. Although tissue acquisition under endoscopic ultrasound (EUS) guidance is an established diagnostic method, procedural outcomes for comprehensive molecular profiling (CMP) have been variable. In a randomised trial, we…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper Bang et al on "Standardisation of EUS-guided FNB technique for molecular profiling in pancreatic cancer: results of a randomised trial" via https://t.co/9VGjrBpbNm #EUS #EndoscopyNews https://t.co/EQlfKyJB5o
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Mashup Score: 1
Objective We present the final analysis results of the phase 2 JADE study (ClinicalTrials.gov Identifier: [NCT03361956][1]). Design 232 patients with chronic hepatitis B (CHB) not currently treated at study start (NCT) at study start or virologically suppressed were randomised to receive 75 mg (part 1) or 250 mg (part 2) JNJ-56136379, a hepatitis B virus (HBV)–capsid assembly modulator, one time…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper by Janssen et al entitled "Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection" via https://t.co/B4eQxnjfQ7 #HBV #LiverTwitter https://t.co/uI79qrVUto
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Mashup Score: 1Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis - 10 month(s) ago
Objective The measure of serum proteome in the preclinical state of Crohn’s disease (CD) may provide insight into biological pathways involved in CD pathogenesis. We aimed to assess associations of serum proteins with future CD onset and with other biomarkers predicting CD risk in a healthy at-risk cohort. Design In a nested case–control study within the Crohn’s and Colitis Canada Genetics…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper by @HaimLeiboIBD et al on "Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight...." via https://t.co/Ge3X6flDlW @SunHoLee15 @MingyueXue @hsteinhart @guthealthmd @RPanaccione @KenCroitoru https://t.co/ogZhFuAalB
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Mashup Score: 0Emerging interleukin targets in the tumour microenvironment: implications for the treatment of gastrointestinal tumours - 10 month(s) ago
The effectiveness of antitumour immunity is dependent on intricate cytokine networks. Interleukins (ILs) are important mediators of complex interactions within the tumour microenvironment, including regulation of tumour-infiltrating lymphocyte proliferation, differentiation, migration and activation. Our evolving and increasingly nuanced understanding of the cell type-specific and heterogeneous…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the #RecentAdvancesInBasicScience review by Dickerson et al on "Emerging interleukin targets in the tumour microenvironment: implications for the treatment of gastrointestinal tumours" via https://t.co/bTU2jJJ0vb @Karan_Immunoonc @pancsurg #GITumours https://t.co/PlGUF1qpag
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Mashup Score: 0Sudden onset of multiple seborrhoeic keratoses in a patient with well-differentiated neuroendocrine tumours of the gut - 10 month(s) ago
A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk (figure 1). The skin lesions started growing approximately 2 years prior. Clinical diagnosis of seborrhoeic keratoses (SK) was confirmed by histopathological examination (figure 2). Work-up of new intermittent dragging pain localised on the lower right abdominal…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
"A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk...." - read the latest #GISnapshot #GUTSnapshot by Schmidt et al via https://t.co/49RhlryT07 #EIM #GUTImages #NETs @emadelomar https://t.co/7eWzsXs6RB
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Mashup Score: 0Acetyltransferase from Akkermansia muciniphila blunts colorectal tumourigenesis by reprogramming tumour microenvironment - 10 month(s) ago
Objective The protein post-translational modification (PTM) in host cells can be rewritten by bacterial enzymes and represents an unprecedented mechanism in the communication between intestinal flora and the host. Although Akkermansia muciniphila has been widely investigated as a probiotic and blunts colitis-associated tumourigenesis in mice, there is little understanding regarding whether A….
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper Jiang et al entitled "Acetyltransferase from Akkermansia muciniphila blunts colorectal tumourigenesis by reprogramming tumour microenvironment" via https://t.co/R1PoDvWzoU #Akkermansia #Microbiome https://t.co/pyxSgKDYsj
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Mashup Score: 0Gut: 72 (8) - 10 month(s) ago
August 2023 – Volume 72 – 8 Inflammatory bowel disease Original research: Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis (2 February, 2023) Frank…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
The magnificent Oxford University, UK. Read in this issue the outstanding #GUTRecentAdvances review by @tom_marjot et al on optimal timing of energy intake & the therapeutic potential of fasting in #NAFLD via https://t.co/7aQqD4AFhN @OCDEM @OxfordBRC @OxfordMedSci @OUHospitals https://t.co/TZwC5LKt74
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Mashup Score: 1Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis - 10 month(s) ago
Objective Biological insights into the stepwise development and progression of colorectal cancer (CRC) are imperative to develop tailored approaches for early detection and optimal clinical management of this disease. Here, we aimed to dissect the transcriptional and immunologic alterations that accompany malignant transformation in CRC and to identify clinically relevant biomarkers through…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper by Roelands et al entitled "Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis" via https://t.co/1G2JE2JPrv #ColorectalCancer https://t.co/p6BPUppf55
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#GUTImage from the #GUTRecentAdvances review by @tom_marjot et al on "Timing of energy intake and the therapeutic potential of intermittent fasting and time-restricted eating in #NAFLD" via https://t.co/UtDVVmqAVw @OCDEM @OxfordBRC @OxfordMedSci @OUHospitals #LiverTwitter https://t.co/eRv911dmdZ