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Mashup Score: 1Sudden onset of multiple seborrhoeic keratoses in a patient with well-differentiated neuroendocrine tumours of the gut - 10 month(s) ago
A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk (figure 1). The skin lesions started growing approximately 2 years prior. Clinical diagnosis of seborrhoeic keratoses (SK) was confirmed by histopathological examination (figure 2). Work-up of new intermittent dragging pain localised on the lower right abdominal…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 2Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis - 10 month(s) ago
Objective In acute pancreatitis (AP), bacterial translocation and subsequent infection of pancreatic necrosis are the main risk factors for severe disease and late death. Understanding how immunological host defence mechanisms fail to protect the intestinal barrier is of great importance in reducing the mortality risk of the disease. Here, we studied the role of the Treg/Th17 balance for…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper by Glaubitz et al entitled "Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis" via https://t.co/OqcPbka4Ya @mruehlemann #AP #Pancreatitis https://t.co/2bon5nDStG
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Mashup Score: 3Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature - 10 month(s) ago
Objective Helicobacter pylori infection is the most prevalent bacterial infection worldwide. Besides being the most important risk factor for gastric cancer development, epidemiological data show that infected individuals harbour a nearly twofold increased risk to develop colorectal cancer (CRC). However, a direct causal and functional connection between H. pylori infection and colon cancer is…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper by Ralser et al entitled "Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature" via https://t.co/hg3nRe1KpZ #HelicobacterPylori #Microbiota https://t.co/OpUdQT8wMR
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Mashup Score: 5Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases - 10 month(s) ago
Objective The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp metabolism end-products are essential to intestinal homeostasis. Here, we investigated the role of metabolites from the kynurenine pathway. Design Targeted quantitative metabolomics was performed in two large human IBD…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper by @ChloeMichaudel, @J_Kirchgesner, @h_sokol et al entitled "Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases" via https://t.co/YeP2KVR91w #IBD #Tryptophan https://t.co/2GlmWqDy7c
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Mashup Score: 0Sudden onset of multiple seborrhoeic keratoses in a patient with well-differentiated neuroendocrine tumours of the gut - 10 month(s) ago
A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk (figure 1). The skin lesions started growing approximately 2 years prior. Clinical diagnosis of seborrhoeic keratoses (SK) was confirmed by histopathological examination (figure 2). Work-up of new intermittent dragging pain localised on the lower right abdominal…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
"A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk...." - read the latest #GISnapshot #GUTSnapshot by Schmidt et al via https://t.co/49RhlryT07 #EIM #GUTImages #NETs @emadelomar https://t.co/9qGKdOBJGE
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Mashup Score: 1Biopsy and blood-based molecular biomarker of inflammation in IBD - 10 month(s) ago
Objective IBD therapies and treatments are evolving to deeper levels of remission. Molecular measures of disease may augment current endpoints including the potential for less invasive assessments. Design Transcriptome analysis on 712 endoscopically defined inflamed (Inf) and 1778 non-inflamed (Non-Inf) intestinal biopsies (n=498 Crohn’s disease, n=421 UC and 243 controls) in the Mount Sinai…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper by Argmann et al entitled "Biopsy and blood-based molecular biomarker of inflammation in IBD" via https://t.co/pA64R32Zjd #IBD #Biomarkers @JeanFredericCo1 https://t.co/8YAFqhGmPE
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Mashup Score: 0Standardisation of EUS-guided FNB technique for molecular profiling in pancreatic cancer: results of a randomised trial - 10 month(s) ago
As clinically actionable genomic lesions are found in almost 30% of pancreatic cancers that can potentially impact management, there has been increased focus on molecular profiling. Although tissue acquisition under endoscopic ultrasound (EUS) guidance is an established diagnostic method, procedural outcomes for comprehensive molecular profiling (CMP) have been variable. In a randomised trial, we…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper Bang et al on "Standardisation of EUS-guided FNB technique for molecular profiling in pancreatic cancer: results of a randomised trial" via https://t.co/9VGjrBpbNm #EUS #EndoscopyNews https://t.co/zQzAWtEkDv
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Mashup Score: 0Sudden onset of multiple seborrhoeic keratoses in a patient with well-differentiated neuroendocrine tumours of the gut - 10 month(s) ago
A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk (figure 1). The skin lesions started growing approximately 2 years prior. Clinical diagnosis of seborrhoeic keratoses (SK) was confirmed by histopathological examination (figure 2). Work-up of new intermittent dragging pain localised on the lower right abdominal…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
"A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk...." - read the latest #GISnapshot #GUTSnapshot by Schmidt et al via https://t.co/49RhlryT07 #EIM #GUTImages #NETs @emadelomar https://t.co/rl2FfuPcTN
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Mashup Score: 0
Objective We present the final analysis results of the phase 2 JADE study (ClinicalTrials.gov Identifier: [NCT03361956][1]). Design 232 patients with chronic hepatitis B (CHB) not currently treated at study start (NCT) at study start or virologically suppressed were randomised to receive 75 mg (part 1) or 250 mg (part 2) JNJ-56136379, a hepatitis B virus (HBV)–capsid assembly modulator, one time…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper by Janssen et al entitled "Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection" via https://t.co/B4eQxnjfQ7 #HBV #LiverTwitter https://t.co/edwkPJR0Cd
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Mashup Score: 0NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications - 10 month(s) ago
Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to a third of the world’s adult population. Several cohort studies have consistently documented that NAFLD (especially in its more advanced forms) is associated with a higher risk of all-cause mortality and that the leading causes of death among patients with NAFLD are cardiovascular diseases (CVDs), followed by…
Source: GutCategories: Cardiologists, Latest HeadlinesTweet-
Non-alcoholic fatty #liver disease (NAFLD) affects up to a third of the world’s adult population & cohort studies have found that the leading causes of death among patients with NAFLD are #cardiovascular. @Gut_BMJ https://t.co/PK3T8R23n8
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"A 63-year-old man presented with an increasing number of pruritic, light to dark brown papules affecting his scalp, forehead and trunk...." - read the latest #GISnapshot #GUTSnapshot by Schmidt et al via https://t.co/49RhlryT07 #EIM #GUTImages #NETs @emadelomar https://t.co/YLShH4ittt