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Mashup Score: 0
A whole-genome sequencing study of Korean individuals with Parkinson’s disease (PD) has identified several new genetic risk factors, ranging from single nucleotide variations (SNVs) to larger DNA deletions. PD is the second most prevalent neurodegenerative disease globally, but most studies have focused on SNVs in European populations. Using whole-genome sequencing, Ji-Hye Oh at the University of…
Source: NatureCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 6Life Habits and Mental Health: Behavioural Addiction, Health Benefits of Daily Habits, and the Reward System - 2 year(s) ago
In this review, the underlying mechanisms of health benefits and the risk of habitual behaviours such as internet use and media multitasking were explored, considering their associations with the reward/motivation system. The review highlights that several …
Source: PubMed Central (PMC)Categories: Healthcare Professionals, Latest HeadlinesTweet-
All #Habits satisfy a craving. When that craving is met, the brain’s reward center activates and releases the pleasure chemical #Dopamine. In order to change a #habit, associate the new behavior with its own rewarding outcome from @4psa 😍 https://t.co/qsy58xsGJO #Productivity https://t.co/eFkRGN45BS
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Mashup Score: 6
The new sensor could be a step forward in dopamine agonist detection, paving the way for molecular diagnosing neurological illnesses.
Categories: Future of Medicine, Latest HeadlinesTweet-
Researchers in Iran have developed a quick, sensitive, and simple test to determine #dopamine levels in biological fluids. The method could help clinicians spot abnormal blood levels of dopamine in patients. Read more: https://t.co/0IPlEx0th7 https://t.co/yvF2GFROfV
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Mashup Score: 5
The new sensor could be a step forward in dopamine agonist detection, paving the way for molecular diagnosing neurological illnesses.
Categories: Future of Medicine, Latest HeadlinesTweet-
Researchers in Iran have developed a quick, sensitive, and simple test to determine #dopamine levels in biological fluids. The method could help clinicians spot abnormal blood levels of dopamine in patients. Read more: https://t.co/0IPlEx0th7 https://t.co/tG5NiCK55h
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Mashup Score: 0
If researchers can successfully use biomarkers to predict which antidepressants will work best for people, it could, finally, be a major step toward much-needed clinical action for patients.
Source: STATCategories: Healthcare Professionals, Latest HeadlinesTweet-
Predictive #biomarkers could ease the exhaustive trial-and-error of #antidepressants https://t.co/w3Se2Hh0Ck via @statnews #MRI #Dopamine #bupropion #depression #PM101
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Mashup Score: 0Unique functional responses differentially map onto genetic subtypes of dopamine neurons - 2 year(s) ago
Dopamine neurons are characterized by their response to unexpected rewards, but they also fire during movement and aversive stimuli. Dopamine neuron diversity has been observed based on molecular expression profiles; however, whether different functions map onto such genetic subtypes remains unclear. Here, we establish that three genetic dopamine subtypes within the substantia nigra pars compacta…
Source: bioRxivCategories: Healthcare Professionals, Latest HeadlinesTweet-
Unique functional responses differentially map onto #genetic subtypes of #dopamine #neurons https://t.co/BSM1LQ7qWb
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Mashup Score: 8Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons - Nature Neuroscience - 2 year(s) ago
This study shows that burst-firing-induced astrocyte signaling potentiates glutamatergic transmission onto dopamine neurons in mouse VTA.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Study highlights the role of #astrocytes in the synaptic regulation of VTA #dopamine neurons @NatureNeuro https://t.co/g7XTzV4YGd https://t.co/2Hm1zlsDbr
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Mashup Score: 5Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons - Nature Neuroscience - 2 year(s) ago
This study shows that burst-firing-induced astrocyte signaling potentiates glutamatergic transmission onto dopamine neurons in mouse VTA.
Source: NatureCategories: Latest Headlines, NeurologyTweet-
Burst firing in individual #dopamine neurons induces a long-lasting potentiation of excitatory synapses on adjacent dopamine neurons, and this plasticity is mediated by #astrocytes https://t.co/ggWHGejnl2
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Mashup Score: 2
Background and Objectives Cross-sectional studies suggest marked dopamine (DA) decline in aging, but longitudinal evidence is lacking. The aim of this study was to estimate within-person decline rates for DA D2-like receptors (DRD2) in aging and examine factors that may contribute to individual differences in DRD2 decline rates. Methods We investigated 5-year within-person changes in DRD2…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
This study examines longitudinal #dopamine D2 receptor changes and cerebrovascular health in aging. Learn more: https://t.co/ERyGHWaaGQ #NeuroTwitter #Neurology https://t.co/Tz8efPaYLl
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Mashup Score: 12Disruption of dopamine receptor 1 localization to primary cilia impairs signaling in striatal neurons - 2 year(s) ago
A rod-shaped appendage called a primary cilium projects from the soma of most central neurons in the mammalian brain. The importance of cilia within the nervous system is highlighted by the fact that human syndromes linked to primary cilia dysfunction, collectively termed ciliopathies, are associated with numerous neuropathologies, including hyperphagia-induced obesity, neuropsychiatric…
Source: Journal of NeuroscienceCategories: General Medicine News, Latest HeadlinesTweet-
A role for cell 'antennae' in managing #dopamine signals in the brain @OhioState @sfnjournals https://t.co/fDepT0K4O0 https://t.co/lnEzBatyW3
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Whole-genome sequencing reveals an association between small genomic #deletions and an increased risk of developing #Parkinson’s disease https://t.co/zrLYiNrZTo #WGS #CNV #GPR27 #enhancer #SNCA #dopamine #TCF7L2 #βcatenin #PM101