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Mashup Score: 7Cutting Edge: l-Arginine Transfer from Antigen-Presenting Cells Sustains CD4+ T Cell Viability and Proliferation - 2 year(s) ago
Metabolomics analyses suggest changes in amino acid abundance, particularly l-arginine (L-ARG), occur in patients with tuberculosis. Immune cells require L-ARG to fuel effector functions following infection. We have previously described an L-ARG synthesis pathway in immune cells; however, its role
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 16STAT3 Gain-of-Function Mutations Underlie Deficiency in Human Nonclassical CD16+ Monocytes and CD141+ Dendritic Cells - 2 year(s) ago
Genetic analysis of human inborn errors of immunity has defined the contribution of specific cell populations and molecular pathways in the host defense against infection. The STAT family of transcription factors orchestrate hematopoietic cell differentiation. Patients with de novo activating
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
#ICYMI @MACattackLab and @klechevskyLab from @WUSTLmed @wusm_pathology @WUSTL_Rheum | #STAT3 gain-of-function #mutation causes a novel disorder of #DendriticCells and #monocytes https://t.co/vxTljTn1C7 #Autoimmunity #hematopoesis https://t.co/Nhqzy00eRq
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Mashup Score: 0Investigations into SCAMP5, a candidate lupus risk gene expressed in plasmacytoid dendritic cells - 3 year(s) ago
Objective We have investigated the molecular function of SCAMP5 , a candidate risk gene for SLE exclusively expressed in plasmacytoid dendritic cells (pDCs) among peripheral leucocytes. Methods We tested the independence of the association in SCAMP5 with SLE by performing conditional analyses. We profiled the expression pattern of SCAMP5 among circulating leucocytes at the transcript and protein…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
This week on LSM #Genetics Ghanem et at. identified SCAMP5 as a novel candidate #Lupus #SLE risk #gene expressed on #pDCs plasmacytoid #dendriticcells on the basis of #genomic #data and expression https://t.co/1H4n987yK1
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Mashup Score: 36Single-cell analysis reveals divergent responses of human dendritic cells to the MVA vaccine - 3 year(s) ago
Infected and noninfected bystander dendritic cells have distinct roles in the response to the vaccine vector MVA.
Source: Science SignalingCategories: Future of Medicine, Latest HeadlinesTweet-
Single-cell analysis illustrates how clusters of #DendriticCells mount one of three varying responses to modified vaccinia Ankara, a smallpox vaccine and an important vector in #VaccineResearch. https://t.co/lDhwRJrlBf @scisignal
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Mashup Score: 9Single-cell analysis reveals divergent responses of human dendritic cells to the MVA vaccine - 3 year(s) ago
Infected and noninfected bystander dendritic cells have distinct roles in the response to the vaccine vector MVA.
Source: Science SignalingCategories: Future of Medicine, Latest HeadlinesTweet-
Single-cell analysis illustrates how clusters of #DendriticCells mount one of three varying responses to modified vaccinia Ankara, a smallpox vaccine and an important vector in #VaccineResearch. https://t.co/lDhwRJ9KJH @scisignal
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Mashup Score: 35Single-cell analysis reveals divergent responses of human dendritic cells to the MVA vaccine - 3 year(s) ago
Infected and noninfected bystander dendritic cells have distinct roles in the response to the vaccine vector MVA.
Source: Science SignalingCategories: Future of Medicine, Latest HeadlinesTweet-
Single-cell analysis from @scisignal illustrates how clusters of #DendriticCells mount one of three varying responses to modified vaccinia Ankara, a smallpox vaccine and an important vector in #VaccineResearch. https://t.co/9FWPAuRihZ https://t.co/w9cY4vFi5o
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Mashup Score: 32Single-cell analysis reveals divergent responses of human dendritic cells to the MVA vaccine - 3 year(s) ago
Infected and noninfected bystander dendritic cells have distinct roles in the response to the vaccine vector MVA.
Source: Science SignalingCategories: Future of Medicine, Latest HeadlinesTweet-
Single-cell analysis from @scisignal illustrates how clusters of #DendriticCells mount one of three varying responses to modified vaccinia Ankara, a smallpox vaccine and an important vector in #VaccineResearch. https://t.co/9FWPAuRihZ https://t.co/mSkGnzocO4
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Mashup Score: 30153 years after discovery of the immune system's dendritic cells, scientists uncover a new subset - 3 year(s) ago
When pathogens invade or tumor cells emerge, the immune system is alerted by danger signals that summon a key battalion of first responders, the unsung heroes of the immune system—a population of starfish-shaped sentinels called dendritic cells.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
153 years after discovery of the #immunesystem's #dendriticcells, scientists uncover a new subset @scisignal https://t.co/Fh6KGZ7g9K
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Mashup Score: 2Research uncovers shortcut dendritic cells take to lymph nodes - 3 year(s) ago
In its response to pathogens and vaccines, the immune system relies on dendritic cells, white blood cells that patrol the body’s tissues, collect components of pathogens and vaccines and transport them via lymphatic vessels to the nearest lymph node. There, they present the collected material to other immune cells in order to trigger an immune response.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
Research uncovers shortcut #dendriticcells take to #lymphnodes @ETH_en @JExpMed https://t.co/cFNLWGxNVX
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Mashup Score: 32Select hyperactivating NLRP3 ligands enhance the TH1- and TH17-inducing potential of human type 2 conventional dendritic cells - 3 year(s) ago
Upon detection of danger signals, such as molecules associated with infectious pathogens, dying cells, or tumor cells, antigen-presenting cells called dendritic cells initiate adaptive immune responses. This response is enhanced through inflammasome signaling that induces cytokine secretion but usually leads to death of the activated cells. Hatscher et al. analyzed human primary DCs from the…
Source: Science SignalingCategories: Future of Medicine, Latest HeadlinesTweet-
Long-lasting types of #DendriticCells, which act as sentinels of the adaptive immune system, may be prime targets for approaches to treat inflammatory diseases or boost the effects of #vaccines and adjuvants, according to research in @SciSignal. ($) https://t.co/3EOWZXpXpO https://t.co/rTQnqQHDuE
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#CuttingEdge from Joseph Qualls @CincyLabs @CincyChildrens | #Larginine transfer from #antigen presenting cells sustains CD4+ #Tcell viability and proliferation https://t.co/WZFMFVs4R1 #ReadTheJI #immunology #DendriticCells #Metabolomics #Tuberculosis https://t.co/f6zfzruaMh