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Mashup Score: 2Therapeutic Small Interfering RNA Targeting Complement C3 in a Mouse Model of C3 Glomerulopathy - 2 year(s) ago
Alternative pathway complement dysregulation with abnormal glomerular C3 deposits and glomerular damage is a key mechanism of pathology in C3 glomerulopathy (C3G). No disease-specific treatments are currently available for C3G. Therapeutics inhibiting complement are emerging as a potential strategy
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 5The multifaceted impact of complement on atherosclerosis - 2 year(s) ago
As one of the cornerstones of innate immunity, the complement system has long been implicated in the pathogenesis of atherosclerosis. Growing evidence demonstrates the presence of complement activation products in human atherosclerotic plaques, where they can exhibit both protective and proatherogenic properties as supported by numerous experimental findings. While complement initiation resulting…
Source: AtherosclerosisCategories: Cardiologists, Latest HeadlinesTweet-
#complement : a new target in #atherosclerosis ? https://t.co/hE71xxfrAU
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Mashup Score: 0An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase - 2 year(s) ago
This article is featured in In This Issue , p.[1477][1] [1]: /lookup/volpage/205/1477
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
#ICYMI from @gregers_rom at Aarhus University | #Nanobody bound to #complement #C4b inhibits #proconvertase assembly and #C3b deposition in #neurites | #ReadTheJI #structuralimmunology #neuroimmunology #FreeToRead https://t.co/PV8errRe6w https://t.co/Git6BpjnFQ
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Mashup Score: 2The H Factor - 2 year(s) ago
Using protein-based mass spectrometry, researchers have identified a family of proteins responsible for dry AMD pathology that can be therapeutically targeted
Source: The OphthalmologistCategories: Latest Headlines, OphthalmologyTweet-
Simon Clark talks about #complement-regulating #proteins that play a major role in #dryAMD pathology https://t.co/aZhTffVQSq @ProfClark @RDUnwin
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Mashup Score: 0Membrane attack complex (MAC) deposition in renal tubules is associated with interstitial fibrosis and tubular atrophy: a pilot study - 2 year(s) ago
Introduction Treatment failures for lupus nephritis (LN) are high with 10%–30% of patients progressing to end-stage renal disease (ESRD) within 10 years. Interstitial fibrosis/tubular atrophy (IFTA) is a predictor of progression to ESRD. Prior studies suggest that tubulointerstitial injury secondary to proteinuria in LN is mediated by complement activation in the tubules, specifically through the…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
This week in #Lupus S&M https://t.co/YMJDpV4Zp3 highlighting the importance of #complement in tubulointerstitial injury in #lupusnephritis. This is timely and impactful with multiple complement targeting therapies under development!
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Mashup Score: 2Membrane attack complex (MAC) deposition in renal tubules is associated with interstitial fibrosis and tubular atrophy: a pilot study - 2 year(s) ago
Introduction Treatment failures for lupus nephritis (LN) are high with 10%–30% of patients progressing to end-stage renal disease (ESRD) within 10 years. Interstitial fibrosis/tubular atrophy (IFTA) is a predictor of progression to ESRD. Prior studies suggest that tubulointerstitial injury secondary to proteinuria in LN is mediated by complement activation in the tubules, specifically through the…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
This week in #Lupus S&M https://t.co/YMJDpV4Zp3 highlighting the importance of #complement in tubulointerstitial injury in #lupusnephritis. This is timely and impactful with multiple complement targeting therapies under development!
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Mashup Score: 1Membrane attack complex (MAC) deposition in renal tubules is associated with interstitial fibrosis and tubular atrophy: a pilot study - 2 year(s) ago
Introduction Treatment failures for lupus nephritis (LN) are high with 10%–30% of patients progressing to end-stage renal disease (ESRD) within 10 years. Interstitial fibrosis/tubular atrophy (IFTA) is a predictor of progression to ESRD. Prior studies suggest that tubulointerstitial injury secondary to proteinuria in LN is mediated by complement activation in the tubules, specifically through the…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
This week on LSM: highlighting the importance of #complement in #tubulointerstitial #injury in #lupusnephritis #lupus #SLE. This is timely and impactful with multiple complement targeting #therapies under development! @LupusMD @WangShudanMD @Montefiore https://t.co/YMJDpV4Zp3
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Mashup Score: 0Membrane attack complex (MAC) deposition in renal tubules is associated with interstitial fibrosis and tubular atrophy: a pilot study - 2 year(s) ago
Introduction Treatment failures for lupus nephritis (LN) are high with 10%–30% of patients progressing to end-stage renal disease (ESRD) within 10 years. Interstitial fibrosis/tubular atrophy (IFTA) is a predictor of progression to ESRD. Prior studies suggest that tubulointerstitial injury secondary to proteinuria in LN is mediated by complement activation in the tubules, specifically through the…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
This week on LSM: highlighting the importance of #complement in #tubulointerstitial #injury in #lupusnephritis #lupus #SLE. This is timely and impactful with multiple complement targeting #therapies under development! @LupusMD @WangShudanMD @Montefiore https://t.co/YMJDpV4Zp3
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Mashup Score: 4Membrane attack complex (MAC) deposition in renal tubules is associated with interstitial fibrosis and tubular atrophy: a pilot study - 2 year(s) ago
Introduction Treatment failures for lupus nephritis (LN) are high with 10%–30% of patients progressing to end-stage renal disease (ESRD) within 10 years. Interstitial fibrosis/tubular atrophy (IFTA) is a predictor of progression to ESRD. Prior studies suggest that tubulointerstitial injury secondary to proteinuria in LN is mediated by complement activation in the tubules, specifically through the…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
This week on LSM: highlighting the importance of #complement in #tubulointerstitial #injury in #lupusnephritis #lupus #SLE. This is timely and impactful with multiple complement targeting #therapies under development! @LupusMD @WangShudanMD @Montefiore https://t.co/YMJDpUNo0t
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Mashup Score: 1
The anaphylatoxin C5a is core effector of complement activation. C5a exerts potent proinflammatory and immunomodulatory actions through interacting with its C5a receptors, C5aR1 and C5aR2, modulating multiple signaling and functional activities of immune cells. Native C5a contains a large N -linked
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
From the Trent Woodruff lab at @UQ_News | Suggest using recombinant human #C5a should be paired with #C5aR1 inhibitors, or purified/synthetic human C5a to confirm relevant findings https://t.co/RmESi8bU8W #ReadTheJI #immunology #complement #innateimmunology #macrophage https://t.co/S3JswTwy23
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#RNA interference-mediated C3 silencing in the liver relevant therapeutic strategy for treating patients with C3 glomerulopathy associated with the haploinsufficiency of complement factor H from Carlamaria Zoja #ReadTheJI #complement #genetherapy https://t.co/KCGSBgV1B5 https://t.co/KHSc46ShtI