• Mashup Score: 1
    Finding a mate for MLCK: improving the potential for therapeutic targeting of gut permeability - 1 year(s) ago

    Elevated intestinal permeability has long been appreciated as a pathophysiological marker of gut inflammatory disease, in particular in inflammatory bowel disease (IBD). In addition to the association of IBD risk genetic variants with multiple aspects of intestinal permeability and barrier dysfunction, increased permeability has been identified as a predictor of IBD onset in healthy first-degree…

    Source: Gut
    Categories: Gastroenterology, Latest Headlines
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      Gut_BMJ

      #GUTImage from the #Commentary by @DecMcCole on "Finding a mate for MLCK: improving the potential for therapeutic targeting of gut permeability" via https://t.co/Sxybn9dUW2 #IBD #GutPermeability https://t.co/FQL2ba5nnX

  • Mashup Score: 2
    JCI - Deciphering the enigma of neuroendocrine prostate cancer - 1 year(s) ago

    The last two decades have seen a remarkable expansion of therapeutic options that improve survival for men with metastatic prostate cancer, yet, for most patients, these treatments ultimately lose efficacy over time (1). Many of these therapies are proficient at targeting the androgen receptor, whose signaling axis is a primary driver of cellular proliferation in prostate adenocarcinoma….

    Source: www.jci.org
    Categories: Hem/Oncs, Latest Headlines
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      Dr_RaviMadan

      RT @jclinicalinvest: Deciphering the enigma of neuroendocrine prostate cancer: https://t.co/7al9Ko81WN In this #Commentary, @FatimaKarzai…

  • Mashup Score: 0
    Risk Stratification and the Art of Medicine - 2 year(s) ago

    Uncertainty is inherent in patient care. Patients with cancer may especially face urgent, life-threatening complications from either the treatment or the disease, and these instances are intermixed with run-of-the-mill reasons for similar symptoms. Is abdominal pain constipation, or is it a bowel perforation? Is worsening malaise from treatment effect, a mild viral infection that will…

    Source: JCO Oncology Practice
    Categories: Hem/Onc News and Journals, Latest Headlines
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      JCOOP_ASCO

      #Commentary @nate_handley: Clinicians must weave together extensive knowledge, deep experience, emotional intelligence, a cultivated gut feeling, AND decision-support tools when treating patients. This is the art and the practice of medicine. 👉 https://t.co/IJWFiXTtnI

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