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Mashup Score: 9A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice - 1 day(s) ago
RLYB331 is a human antibody that increases hepcidin, reduces iron overload, and ameliorates ineffective erythropoiesis in β-thalassemiaCombination with RAP
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Mashup Score: 30Thrombotic events associated with low baseline direct oral anticoagulant levels in atrial fibrillation: the MAS study - 2 day(s) ago
A relationship between low baseline DOAC levels and thrombotic events in 1-year follow-up was found.Early measurement allows the identification of patients
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Mashup Score: 11Six-year follow-up and subgroup analyses of a phase 2 trial of venetoclax for del(17p) chronic lymphocytic leukemia - 2 day(s) ago
Continuous venetoclax monotherapy for untreated or R/R del(17p) CLL led to a median PFS of 28.2 months and median OS of 62.5 months.Subgroup analysis sugge
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Mashup Score: 4Guadecitabine vs TC in relapsed/refractory AML after intensive chemotherapy: a randomized phase 3 ASTRAL-2 trial - 2 day(s) ago
There was no clear survival benefit for guadecitabine over standard-of-care in patients with relapsed/refractory AML.Guadecitabine produced higher clinical
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Mashup Score: 13Structural variants involving MLLT10 fusion are associated with adverse outcomes in pediatric acute myeloid leukemia - 3 day(s) ago
Pediatric MLLT10+ AML have poor prognosis and may benefit from targeted therapies.Patients with PICALM::MLLT10+ and X::MLLT10+ exhibit DNA hypermethylation
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Mashup Score: 22Flares of acute graft-versus-host disease: a Mount Sinai Acute GVHD International Consortium analysis - 5 day(s) ago
After initial clinical response, flares of acute GVHD are common and associated with higher NRM.MAGIC biomarkers at first CR/VGPR can predict GVHD flares.
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Mashup Score: 17Incidence and risk factors of pain crisis after hematopoietic cell transplantation for sickle cell disease - 5 day(s) ago
Recurrence of VOC requiring hospitalization or treatment occurs in 8.7% of patients after HCT with stable donor engraftment in SCD.GF, age at HCT, prior hi
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Mashup Score: 40Steroid tapering after GVHD Rx: not too fast, not too slow - 6 day(s) ago
In this issue of Blood Advances, Akahoshi et al1 provided evidence that higher serum concentrations of suppression of tumorigenicity 2 (ST2) and regenerati
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Mashup Score: 1Better eat! - 6 day(s) ago
In this issue of Blood Advances, Lineburg et al describe the interplay between graft-versus-host disease (GVHD), hematopoietic stem cell (HSC) engraftment,
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Mashup Score: 9Survival for the fittest: guadecitabine in rel/ref AML - 6 day(s) ago
Relapsed or refractory acute myeloid leukemia (AML) has an extremely poor prognosis because of intrinsic chemotherapy resistance and high rates of relapse,
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Combination with RAP-536L, simultaneously corrects iron overload, ineffective erythropoiesis, splenomegaly, and hematological parameters. https://t.co/Vy6sp7vf8u #redcellsironanderythropoiesis https://t.co/zcR1ikXLBX