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    Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas - Clinical Epigenetics - 1 year(s) ago

    Background Early detection has proven to be the most effective strategy to reduce the incidence and mortality of colorectal cancer (CRC). Nevertheless, most current screening programs suffer from low participation rates. A blood test may improve both the adherence to screening and the selection to colonoscopy. In this study, we conducted a serum-based discovery and validation of cfDNA methylation biomarkers for CRC screening in a multicenter cohort of 433 serum samples including healthy controls, benign pathologies, advanced adenomas (AA), and CRC. Results First, we performed an epigenome-wide methylation analysis with the MethylationEPIC array using a sample pooling approach, followed by a robust prioritization of candidate biomarkers for the detection of advanced neoplasia (AN: AA and CRC). Then, candidate biomarkers were validated by pyrosequencing in independent individual cfDNA samples. We report GALNT9, UPF3A, WARS, and LDB2 as new noninvasive biomarkers for the early detection o

    Source: clinicalepigeneticsjournal.biomedcentral.com
    Categories: Future of Medicine, Latest Headlines
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      ManelEsteller

      Glad to have participated in #colorectal #cancer #CRC screening study using DNA #methylation biomarkers in cell-free DNA #cfDNA of more than 400 samples; article published in Clinical Epigenetics @BioMedCentral led by Loretta De Chiara @cinbio_uvigo @uvigo https://t.co/CqBTwWmd6w https://t.co/NY9gyydutH

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    Cesare Hassan on Using AI for Detecting Colorectal Polyps - 1 year(s) ago

    There’s a growing need for cost-saving strategies that allow for optically diagnosing colorectal polyps in order to reduce the patient, economic, and environmental burden of polypectomy and pathology. One recommendation has been to adopt a leave-in-situ approach for small, non-threatening rectosigmoid hyperplastic polyps ≤5 mm and a resect-and-discard approach for more proximal lesions ≤5 mm.

    Source: www.medpagetoday.com
    Categories: General Medicine News, Latest Headlines
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      medpagetoday

      What had previous research shown about the potential for an artificial intelligence (#AI) approach to #colorectal polyps? #AGAReadingRoom @AmerGastroAssn #Gastroenterology Read more: https://t.co/Vz55OhC1Qs https://t.co/z3vuYqN5FG

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    SurgOnc Today® - 1 year(s) ago

    SurgOnc Today® is an educational podcast for cancer surgeons from the Society of Surgical Oncology. Each episode features conversations with individuals who are experts within their respective fields and are members of SSO. Listen to the most recent episodes below or find all of the SurgOnc Today® episodes, organized by disease site, on ExpertEd@SSO and  in the … SurgOnc Today® Read More »

    Source: www.surgonc.org
    Categories: Hem/Onc News and Journals, Latest Headlines
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      SocSurgOnc

      📣 Contemplating a career as a surgical oncologist? Then this episode of SurgOnc Today® is for you! 🎙️ @adwilliams5, @DrZacharyJBrown & @globalsurgallie discuss #surgicaloncology career options, including #breast, #hepatobiliary & #colorectal Listen now: https://t.co/ehFdXjMlcT https://t.co/fSx7Q9Zl1U

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