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Mashup Score: 12A Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring - 3 day(s) ago
Micronutrient deficiency (MND) (ie, lack of vitamins and minerals) during pregnancy is a major public health concern. Historically, studies have considered micronutrients in isolation; however, MNDs rarely occur alone. The impact of co-occurring MNDs on public health, mainly in shaping mucosal colonization by pathobionts from the Enterobacteriaceae family, remains undetermined due to lack of relevant animal models.
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 9Noncanonical TRAIL Signaling Promotes Myeloid-Derived Suppressor Cell Abundance and Tumor Growth in Cholangiocarcinoma - 10 day(s) ago
Proapoptotic tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) signaling as a cause of cancer cell death is a well-established mechanism. However, TRAIL-receptor (TRAIL-R) agonists have had very limited anticancer activity in human beings, challenging the concept of TRAIL as a potent anticancer agent. Herein, we aimed to define mechanisms by which TRAIL+ cancer cells can leverage noncanonical TRAIL signaling in myeloid-derived suppressor cells (MDSCs) promoting their abundance in murine cholangiocarcinoma (CCA).
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 14Replication Efficiency of SARS-CoV-2 Omicron Subvariants BA.2.75, BA.5, and XBB.1 in Human Mini-Gut Organoids - 17 day(s) ago
We and others have reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19), can propagate in human intestinal organoids.1,2 We also demonstrated that the Omicron BA.1 and BA.2 lineages have reduced replication efficiency compared with the Delta variant.1 Recently, the Omicron subvariants, namely BA.2.75, BA.5, and XBB.1, have emerged and became prevalent worldwide; however, their ability to replicate and persist in the intestinal tract is not well understood.
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 44“The Good, the Bad, and the Ugly” – About Diverse Phenotypes of Hepatic Stellate Cells in the Liver - 24 day(s) ago
Hepatic stellate cells (HSCs) and their activated derivatives, often referred to as myofibroblasts (MFs), play a key role in progression of chronic liver injuries leading to fibrosis, cirrhosis, and hepatocellular carcinoma. Until recently, MFs were considered a homogenous cell type majorly due to lack of techniques that allow complex molecular studies at a single-cell resolution. Recent technical advancements in genetic lineage-tracing models as well as the exponential growth of studies with single-cell transcriptome and proteome analyses have uncovered hidden heterogeneities among the HSC and MF populations in healthy states as well as chronic liver injuries at the various stages of tissue deformation.
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 16The Interplay of TGF-β1 and Cholesterol Orchestrating Hepatocyte Cell Fate, EMT, and Signals for HSC Activation - 1 month(s) ago
Transforming growth factor-β1 (TGF-β1) plays important roles in chronic liver diseases, including metabolic dysfunction–associated steatotic liver disease (MASLD). MASLD involves various biological processes including dysfunctional cholesterol metabolism and contributes to progression to metabolic dysfunction–associated steatohepatitis and hepatocellular carcinoma. However, the reciprocal regulation of TGF-β1 signaling and cholesterol metabolism in MASLD is yet unknown.
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet-
New findings suggest that the adverse effects encountered with cholesterol-lowering treatments should always be considered when treating #MASLD patients with statins, which is of special relevance to TGF-β-targeted therapies. Learn more at ➡️🔗https://t.co/ZprTAlJTzB @sdooley1b https://t.co/twrfFHVCUY
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Mashup Score: 15Altered B-Cell Expansion and Maturation in Draining Mesenteric Lymph Nodes of Inflamed Gut in Crohn’s Disease - 1 month(s) ago
Recent studies have investigated the role of B-cell responses in ulcerative colitis, which exclusively affects the colon, whereas data in Crohn’s disease (CD), which mainly affects the terminal ileum, are insufficient.1–4 Granuloma formation within the thickened, inflamed mesentery of patients with CD, however, is associated with significantly worse outcome,5–7 and microstructural analysis has suggested increased numbers of B cells in CD mesentery.8 Although a healthy orchestrated mucosal immune response involves B-cell maturation and development of IgA-secreting plasma cells directed toward more invasive strains of bacteria, anticommensal IgG can be found in patients with CD, which usually are absent in healthy controls.
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 20Antagonism Between Gut Ruminococcus gnavus and Akkermansia muciniphila Modulates the Progression of Chronic Hepatitis B - 1 month(s) ago
A long immune-tolerant (IT) phase lasting for decades and delayed HBeAg seroconversion (HBe-SC) in patients with chronic hepatitis B (CHB) increase the risk of liver diseases. Early entry into the immune-active (IA) phase and HBe-SC confers a favorable clinical outcome with an unknown mechanism. We aimed to identify factor(s)Â triggering IA entry and HBe-SC in the natural history of CHB.
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 5IGF2BP1/IMP1 deletion enhances a facultative stem cell state via regulation of MAP1LC3B - 2 month(s) ago
The intestinal epithelium interfaces with a diverse milieu of luminal contents while maintaining robust digestive and barrier functions. Facultative intestinal stem cells are cells that survive tissue injury and divide to re-establish the epithelium. Prior studies demonstrate autophagic state as functional marker of facultative intestinal stem cells, but regulatory mechanisms are not known. The current study evaluated a post-transcriptional regulation of autophagy as an important factor for facultative stem cell state and tissue regeneration.
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 18BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation - 2 month(s) ago
Breast regression protein 39 (BRP39) (Chi3L1) and its human homolog YKL-40, is an established biomarker of liver fibrosis in nonalcoholic steatohepatitis (NASH) patients, but its role in NASH pathogenesis remains unclear. We recently identified Chi3L1 as one of the top up-regulated genes in mice with inducible gain-of-function NOD-like receptor protein 3 (NLRP3) activation that mimics several liver features of NASH. This study aimed to investigate the effects of BRP39 deficiency on NLRP3-induced liver inflammation using tamoxifen-inducible Nlrp3 knockin mice sufficient (Nlrp3A350V CRT) and deficient for BRP39 (Nlrp3A350V/BRP-/- CRT).
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 14Dysregulation of the Environmental Sensor Aryl Hydrocarbon Receptor Affects Differentiation of Human Colon Organoids - 2 month(s) ago
Gut disorders such, as inflammatory bowel disease (IBD), have increased dramatically in the past 50 years, driven by incompletely defined environmental factors including diet, with reduced intake of substances such as indole compounds, which function as aryl hydrocarbon receptor (AHR) ligands. The AHR resides in the cytoplasm complexed with chaperones, and upon ligand binding translocates to the nucleus where it dimerizes with its partner aryl hydrocarbon nuclear translocator, and initiates the transcription of a wide range of target genes.
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
You are what your mother ate!🤰Explore the insights into transgenerational effects of early-life maternal nutrition: https://t.co/XTTFvZR0h0 🖋️@FinlayLab @ravi_holani https://t.co/bDDpi5jirW