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Mashup Score: 0Improving clots in trauma - 7 month(s) ago
In this issue of Blood, Han et al report in vitro studies and an in vivo rat model of polytrauma that demonstrate that leukocyte inflammation contributes to tra
Source: ashpublications.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 4Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma - 1 year(s) ago
This randomized clinical trial examines whether systematic 4-factor prothrombin complex concentrate administration combined with a ratio-based transfusion protocol is superior to ratio-based transfusion alone in reducing 24-hour total blood product consumption in patients at risk of massive…
Source: jamanetwork.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RCT. In patients with major trauma and at risk of massive transfusion, the use of 25u/kg 4-factor PCC did not reduce transfusion requirements. https://t.co/vxAWW8Zjh6 #PCC #Trauma #Coagulopathy https://t.co/PXBmyOW4u8
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Mashup Score: 1STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion - 1 year(s) ago
Identifying mechanisms of platelet activation would improve our limited understanding of septic-induced coagulopathy. Yang et al. reveal that the DNA sensor, STING, in platelets promotes their granule secretion, which drives subsequent septic thrombosis. Furthermore, this work identifies a STING-STXBP2 interaction as a potential target for sepsis interventions.
Source: ImmunityCategories: Infectious Disease, Latest HeadlinesTweet-
💭 What are the mechanisms behind platelet activation and #coagulopathy during #sepsis? In this @ImmunityCP study, scientists tackled this question using the cecal ligation and puncture model. #NETosis Learn more: 📘 https://t.co/4KICbo7bQf https://t.co/Duq7AgveRF
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Mashup Score: 1Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation - 2 year(s) ago
Survival of pig cardiac xenografts in a non-human primate (NHP) model has improved significantly over the last 4 years with the introduction of costimulation blockade based immunosuppression (IS) and genetically engineered (GE) pig donors. The longest survival of a cardiac xenograft in the heterotopic (HHTx) position was almost 3 years and only rejected when IS was stopped. Recent reports of…
Source: FrontiersCategories: Latest Headlines, TransplantationTweet-
The #progress of cardiac Xtx has been immense. The increase of #xenografts #immunocompatibility from genetically engineered pigs, along with targeted immunosuppression, will pave the way to advance further in the field. https://t.co/WxN2bts0KR 9/ https://t.co/kDXxjgZFLU
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To achieve long-term xenograft survival, various #immunosuppression regimens have been used along with GE pigs. https://t.co/WxN2bts0KR 8/ https://t.co/f99OSdQIyQ
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Several #genetic #strategies have been developed to prevent early graft failure from preformed antibodies and coagulation dysfunction resulting in generation of GE pigs. https://t.co/WxN2bts0KR 7/ https://t.co/4dRoQPafFv
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Furthermore, while organs such as kidneys can be accommodated in the abdomen, the growth of a heart xenograft is more problematic, in fact despite several anatomical and physiological similarities between pigs and humans, their growth rate is different. https://t.co/WxN2bts0KR 6/
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Another potential problem for cardiac Xtx is a zoonotic viral transmission from swine, most notable of which is a porcine endogenous retrovirus. However, studies have shown complete elimination of all copies of it in donor pigs. https://t.co/WxN2bts0KR 5/
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Coagulation dysregulation is also a major impediment to succeed. The most extreme manifestations are systemic consumptive #coagulopathy, with thrombocytopenia and bleeding, ultimately leading to graft loss for ischemia from thrombotic #microangiopathy. https://t.co/WxN2bts0KR 4/
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The presence of natural #preformed #antibodies against pig antigens is a primary and significant hurdle for the success of cardiac XTx. Besides, acute cellular #rejection of cardiac xenografts can be mediated by innate and adaptive immune response. https://t.co/WxN2bts0KR 3/
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In the past few years, substantial progress has been made in the #xenotransplantation (XTx) field. With the discovery and use of novel #molecular #biology techniques, genetically engineered (GE) porcine organ donors have been created. https://t.co/WxN2bts0KR 2/
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🥁Hot off the press from Professor Muhammad M. Mohiuddin's group👉Cardiac #Xenotransplantation: #Progress in Preclinical Models and Prospects for Clinical Translation https://t.co/WxN2bts0KR 1/ https://t.co/VVwkzTM2Pb
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Mashup Score: 0Heatstroke-induced coagulopathy: Biomarkers, mechanistic insights, and patient management - 2 year(s) ago
Heatstroke is increasingly becoming a significant concern due to global warming. Systemic inflammation and coagulopathy are the two major factors that provoke life-threatening organ dysfunction in heatstroke. Dysregulated thermo-control induces cellular injury, damage-associated molecular patterns release, hyperinflammation, and hypercoagulation with suppressed fibrinolysis to produce…
Source: EClinicalMedicineCategories: Latest Headlines, PayerTweet-
New Review: Heatstroke-induced #coagulopathy: Biomarkers, mechanistic insights, and patient management Read more here: https://t.co/utF3eDNRen https://t.co/CleHg518Ej
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Mashup Score: 0Heatstroke-induced coagulopathy: Biomarkers, mechanistic insights, and patient management - 2 year(s) ago
Heatstroke is increasingly becoming a significant concern due to global warming. Systemic inflammation and coagulopathy are the two major factors that provoke life-threatening organ dysfunction in heatstroke. Dysregulated thermo-control induces cellular injury, damage-associated molecular patterns release, hyperinflammation, and hypercoagulation with suppressed fibrinolysis to produce…
Source: EClinicalMedicineCategories: Latest Headlines, PayerTweet-
New Review: #Heatstroke-induced '#coagulopathy: Biomarkers, mechanistic insights, and patient management. Read here: https://t.co/ExIyjgbQFt https://t.co/WMzFGolhZE
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Mashup Score: 8
Background Outcome data about the use of tranexamic acid (TXA) in civilian patients in mature trauma systems are scarce. The aim of this study was to determine how severely injured patients are affected by the widespread prehospital use of TXA in Germany. Methods The international TraumaRegister DGU® was retrospectively analyzed for severely injured patients with risk of bleeding (2015 until…
Source: Critical CareCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OA #Tranexamic_acid: in severely #injured patients is associated with a lower risk of massive #transfusion and lower #mortality https://t.co/3spGP3Uy20 #FOAMed #FOAMcc @ISICEM @jlvincen #BMC #trauma #intensive_care #TXA #Bleeding #Coagulopathy @haemorrage https://t.co/SpglW9qY2I
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Mashup Score: 0Coagulopathy and Venous Thromboembolic Events Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy - 3 year(s) ago
Background Coagulopathy after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is recognized but few details have been studied. Objectives The aim of this study was to investigate changes in coagulation biomarkers and their predictive ability for venous thromboembolism (VTE). Methods Patients undergoing CRS and HIPEC at Uppsala University Hospital, Sweden, from…
Source: Annals of Surgical OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
#Coagulopathy and #VenousThromboembolic Events Following #CytoreductiveSurgery and #HIPEC. https://t.co/CRrGLz7InV #VisualAbstract @McMastersKelly https://t.co/QRpg18hD3B
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Mashup Score: 8Cefazolin and rifampin: A coagulopathy-inducing combination - 3 year(s) ago
AbstractPurpose. To identify risk factors that may predispose patients to rifampin- and cefazolin-induced coagulopathy.Summary. An 86-year-old man with a histor
Source: OUP AcademicCategories: Infectious Disease, Latest HeadlinesTweet-
#ScholarlySunday Have you seen #coagulopathy with prolonged prothrombin time and elevated INR induced by Cefazolin-Rifampin? Illustrative case reported by fellows @N_CastilloMD @PoojaGurram with IDPharmD @Stevens_AK @MsSmallsO and faculty @GinaSuhMD https://t.co/ZZIt9QCwIn https://t.co/b6yom5Jcb1
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Mashup Score: 3Early Coagulopathy in Pediatric Traumatic Brain Injury: A Pediatric Acute and Critical Care Medicine Asian Network (PACCMAN) Retrospective Study - 3 year(s) ago
AbstractBACKGROUND. Although early coagulopathy increases mortality in adults with traumatic brain injury (TBI), less is known about pediatric TBI.OBJECTIVE. To
Source: OUP AcademicCategories: Latest Headlines, PediatricsTweet-
#coagulopathy #TBI @paccman_asia @leejanhau @Olive_LeePeiEe #pedsicu #neuroPICU @NeurosurgeryCNS https://t.co/nHfyWncUz8
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Improving #Clots in trauma 👉https://t.co/EcKH9cOBCu Great read from the latest edition! @Blood #Coagulopathy #TraumaInduced https://t.co/H1Al2k43P9