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Mashup Score: 3
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 3
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, Oncologists1Tweet-
“Breast tumors with rare histologies are overrepresented among high-risk #breastcancers and denote an area with limited trial data and unmet clinical need,” noted Alexandra Thomas, MD, FACP, a medical oncologist at @DukeCancer. Keep reading: https://t.co/h2C60Bl0r0 https://t.co/6WDifnz2T5
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Mashup Score: 127Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes - 19 day(s) ago
Abstract. Breast cancer is the most commonly diagnosed cancer in women, with distant metastasis being the main cause of breast cancer-related deaths. Elucidating the changes in the tumor and immune ecosystems that are associated with metastatic disease is essential to improve understanding and ultimately treatment of metastasis. Here, we developed an in-depth, spatially resolved single-cell atlas of the phenotypic diversity of tumor and immune cells in primary human breast tumors and matched distant metastases, using imaging mass cytometry to analyze a total of 75 unique antibody targets. While the same tumor cell phenotypes were typically present in primary tumors and metastatic sites, suggesting a strong founder effect of the primary tumor, their proportions varied between matched samples. Notably, the metastatic site did not influence tumor phenotype composition, except for the brain. Metastatic sites exhibited a lower number of immune cells overall, but had a higher proportion of m
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet-
From the lab (@BodenmillerLab) that invented imaging mass cytomtery (IMC) comes this new @CR_AACR paper on mapping the tumor phenotypes & immune compositions of primary & metastatic #BreastCancers. https://t.co/YFRPtZuJ9J Fantastic resource of an optimized 75 marker IMC panel… https://t.co/EWwwJKiq1s https://t.co/YbVwLwEIV5
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Mashup Score: 0Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor–Positive Metastatic Breast Cancers - 1 year(s) ago
Palbociclib-resistant breast cancers respond to abemaciclib and express pathway-specific signatures of sensitivity, providing a biomarker-driven therapeutic option for patients with metastatic breast cancer following disease progression on cyclin-dependent kinases 4/6 inhibitors.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Attending #Targets23? Read the article in the newest issue— Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor–Positive #Metastatic #BreastCancers, by @kandymarsy et al. https://t.co/0Ona0XwQrF @MDAndersonNews https://t.co/K65GoHc9Kh
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Mashup Score: 0
An abstract is unavailable.
Source: journals.lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Researchers recently launched a global genomics study of #prostate and #breastcancers, which carry a disproportionately high risk for poor outcomes in men and women of African ancestry. The goal is to identify genetic and molecular drivers of the cancers. https://t.co/so5H5FbiBl https://t.co/22DtsjEAJT
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Mashup Score: 1A bi-steric mTORC1-selective inhibitor overcomes drug resistance in breast cancer - Oncogene - 1 year(s) ago
Activation of the PI3K-mTOR pathway is central to breast cancer pathogenesis including resistance to many targeted therapies. The mTOR kinase forms two distinct complexes, mTORC1 and mTORC2, and understanding which is required for the survival of malignant cells has been limited by tools to selectively and completely impair either subcomplex. To address this, we used RMC-6272, a bi-steric…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
💊@SBLabUCSF identified a new class of drugs that can be used to treat aggressive, treatment resistant #BreastCancers 🔬https://t.co/sAuqJOGDdN #OpenAccess #mTOR
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Mashup Score: 3Synchronous Bilateral Breast Cancers Are Distinct Diseases - 2 year(s) ago
Contralateral tumor subtype affects immune infiltration and therapy response in synchronous bilateral breast cancer.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Read this week's Cancer Discovery #ResearchWatch: Synchronous Bilateral #BreastCancers Are Distinct Diseases, summarizing the work of @ashamypetit, @JoshWaterfall, @FabienReyal et al. https://t.co/z9SR6jMm29 @institut_curie https://t.co/CChfhC1u4i
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Mashup Score: 0Wolters Kluwer Health - 2 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Now in its sixth year, the #WISDOM study is comparing a personalized #screening strategy to traditional #mammography to determine which works best at finding early #breastcancers before they progress: https://t.co/9Mg16xRCZm #BCSM #cancerscreening #cancerprevention #womenshealth https://t.co/UghAcrIWTT
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Mashup Score: 0Wolters Kluwer Health - 2 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Now in its sixth year, the #WISDOM study is comparing a personalized #screening strategy to traditional #mammography to determine which works best at finding early #breastcancers before they progress: https://t.co/9Mg16xRCZm #BCSM #cancerscreening #cancerprevention #womenshealth https://t.co/71BuHqa7Rx
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Mashup Score: 0Wolters Kluwer Health - 2 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Now in its sixth year, the #WISDOM study is comparing a personalized #screening strategy to traditional #mammography to determine which works best at finding early #breastcancers before they progress: https://t.co/9Mg16xRCZm #BCSM #cancerscreening #cancerprevention #womenshealth https://t.co/vp1YDKMJwW
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“Breast tumors with rare histologies are overrepresented among high-risk #breastcancers and denote an area with limited trial data and unmet clinical need,” noted Alexandra Thomas, MD, FACP, a medical oncologist at @DukeCancer. Keep reading: https://t.co/h2C60Bl0r0 https://t.co/6WDifnz2T5