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Mashup Score: 0Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth - Nature Cancer - 1 year(s) ago
Yuan et al. demonstrate that cancer-associated fibroblasts in the pancreatic tumor microenvironment secrete nucleosides through autophagy in an NUFIP1-dependent manner, thereby inducing glucose consumption under glutamine-deprived conditions and promoting tumor growth.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0The mechanisms and roles of selective autophagy in mammals - Nature Reviews Molecular Cell Biology - 1 year(s) ago
Selective autophagy engages several cargo receptors that target specific, potentially toxic, content (damaged organelles, protein aggregates, pathogens) for lysosomal degradation. Understanding of the mechanisms governing this process in mammals has expanded in recent years, opening the prospects for enhancing selective autophagy to boost cellular quality control capabilities.
Source: NatureCategories: Allergy-Immunology, Latest HeadlinesTweet-
Are you looking for a comprehensive Review on selective #autophagy? Tamotsu Yoshimori, @LabYoule and colleagues discuss the different autophagy pathways in their recent #NRMCBReview: 🚨 https://t.co/uI3ZvLwu4P https://t.co/8pFwjHXg41
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Mashup Score: 0The Novel Lysosomal Autophagy Inhibitor (ROC-325) Ameliorates Experimental Pulmonary Hypertension - PubMed - 1 year(s) ago
These data indicate that ROC-325 is a promising novel agent for the treatment of PH that inhibits autophagy, downregulates HIF levels, and increases nitric oxide production.
Source: PubMedCategories: Latest Headlines, PulmonologyTweet-
The #Novel #Lysosomal #Autophagy #Inhibitor (ROC-325) Ameliorates #Experimental #Pulmonary #Hypertension #PH https://t.co/vCDe6I9M5d https://t.co/3UG7ZgDB7V
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Mashup Score: 0
Abstract. Lysosomal autophagy inhibition (LAI) with hydroxychloroquine or DC661 can enhance cancer therapy, but tumor regrowth is common. To elucidate LAI resistance, proteomics and immunoblotting demonstrated that LAI induced lipid metabolism enzymes in multiple cancer cell lines. Lipidomics showed that LAI increased cholesterol, sphingolipids, and glycosphingolipids. These changes were…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Targeting UGCG Overcomes Resistance to Lysosomal #Autophagy Inhibition, by @VaibhavJain_PhD, David Speicher, @AmaravadiRavi et al. https://t.co/QMnPzqbBnc @TheWistar @PennCancer https://t.co/4FCFOUZEha
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Mashup Score: 3Multi-omics characterization of autophagy-related molecular features for therapeutic targeting of autophagy - Nature Communications - 2 year(s) ago
Autophagy has been typically associated with resistance to cancer therapy, and autophagy inhibitors have been explored in cancer. Here, the authors investigate autophagy signatures and their association with drug response in cancer, and find that autophagy induction can actually sensitise cancer cells to therapy.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
#Multiomics analysis of #autophagy signatures and their association with #DrugResponse in cancer reveals that autophagy induction can actually sensitise cancer cells to #therapy #CancerResearch by @lenghan_bioinfo et al. @natrescancer https://t.co/Gk01J0XLtA https://t.co/sWOvya7xmJ
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Mashup Score: 0Development Mode - 2 year(s) ago
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Source: et.alCategories: Latest Headlines, PediatricsTweet-
New Infographic! 📃 by @gigenace "#Rapamycin induces #autophagy and #apoptosis in #Kaposiformhemangioendothelioma #primarycells #invitro" ZuoPeng Wang https://t.co/Ovgblefsnc. Full Article: https://t.co/tFUHA2AIdn #SoMe4PedSurg #basicscience #Oncology https://t.co/Mt5ViIUi49
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Mashup Score: 7
Ovarian function and reserve (conceptually depicted here as an ovum surrounded by follicular cells) is impaired in mice treated with immune checkpoint…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Don't miss the @NatureCancer 🌞AUGUST🌞 ISSUE– this month read all about #cancervaccines, #CAFs & #autophagy, #immunotherapy & implications on #fertility, #stemcells, #TumorEvolution #neuroblastoma and so much more! Find it all here: https://t.co/8C8ImOaT4F https://t.co/RRNnI2FM0T
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Mashup Score: 2Episode 36 – Evert Njomen: Hacking our cellular recycling system to prevent the next deadly pathogen - 2 year(s) ago
Dr. Evert Njomen is a postdoctoral researcher in the lab of Professor Ben Cravatt, based in the Department of Chemistry. Listen as we talk about the autophagy process to cleanse cells, new ways of de
Source: SoundCloudCategories: General Medicine News, Latest HeadlinesTweet-
The new episode of #ScienceChangingLife features chemist @EvertNjomen, from Prof. Benjamin Cravatt's lab. Evert discusses #autophagy and how its chemical activation could be a solution to dealing with antibiotic resistance & new pathogens. Listen now: https://t.co/nS2PDndh82
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Mashup Score: 1
AbstractAims. Growing evidence correlate the accrual of the sphingolipid ceramide in plasma and cardiac tissue with heart failure (HF). Regulation of sphingolip
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Making #HeartFailure a 'No Go’🛑 Nogo-A blockade of SPT ⬇️de novo ceramide synthesis to ⬆️beneficial #autophagy & ⬇️#ROS, protecting against heart failure https://t.co/Qpy8MW3TQM @CVR_TomaszGuzik @DrMikeDrozd @glenpyle #metabolism #ESCBasicScience #CardiovascularResearch https://t.co/zVIxsAV4pT
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Mashup Score: 0
Alzheimer’s disease has long thwarted our best efforts to pinpoint its underlying causes. Now, a new study in mice suggests that ‘poisonous flowers’ bulging with cellular debris could be the root source of one hallmark of the wretched disease and a b
Source: ScienceAlertCategories: Healthcare Professionals, Latest HeadlinesTweet-
Nicely written article re: #autophagy, #amyloid, and #aducanumab . #Alzheimer #neurons https://t.co/ZI3X4W1aMd
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“Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth” by #YingZhao & Co. #autophagy #fibroblasts #PancreaticCancerAwarenessMonth🗣️💜 👇 https://t.co/TT041DqByY https://t.co/lN4eZbxslv