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Mashup Score: 3
Nature Cancer – In this work, we demonstrate the transcriptional networks that link breast cancer subtypes and their cells of origin, and how transcriptional signatures differ between benign cells…
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 75
Nature Cancer – Mizutani et al. use a model that recapitulates the colon adenoma–carcinoma transition through the sequential elimination of media factors leading to spontaneous accumulation…
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 19Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis - 7 day(s) ago
Nature Cancer – Snyder and colleagues present a comprehensive multiomic atlas of normal mucosal, benign polyps and dysplastic polyps from six persons with familial adenomatous polyposis, comprising…
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 84Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages - 7 day(s) ago
Nature Cancer – Ding and colleagues use bulk, single-cell and single-nucleus multi-omics together with spatial transcriptomics and multiplex imaging of clinical tumor samples to characterize gene…
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 102Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis - 7 day(s) ago
Nature Cancer – Snyder and colleagues show global loss of promoter–enhancer connectivity during early colorectal carcinogenesis and the dependency of gene dysregulation during this process on…
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 175Nature Cancer - Mapping the microenvironment architecture of hepatocellular carcinoma - 11 day(s) ago
Spatial single-cell profiling of clinical hepatocellular carcinoma samples maps microenvironment architecture and heterogeneity, identifying functionally…
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 112Two distinct epithelial-to-mesenchymal transition programs control invasion and inflammation in segregated tumor cell populations - 22 day(s) ago
Nature Cancer – Youssef et al. study epithelial-to-mesenchymal transition (EMT) programs in breast cancer and identify two interdependent trajectories coexisting within tumors, with EMT…
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 18Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors - 23 day(s) ago
Nature Cancer – Burr et al. analyze multiple primary EGFR-mutant lung tumors from ten patients and define developmental mosaicism as a mechanism underlying multiple tumor presentation in this setting.
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 22
Nature Cancer – Sawyers and colleagues describe an in vivo platform used to explore the dynamics and key factors of neuroendocrine lineage transformation. They find that Ascl1 depletion blocks…
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 20CAR-redirected natural killer T cells demonstrate superior antitumor activity to CAR-T cells through multimodal CD1d-dependent mechanisms - 29 day(s) ago
Nature Cancer – Dotti and colleagues show that chimeric antigen receptor (CAR) natural killer T cells have superior antitumor activity compared with CAR-T cells, mediated through the elimination of…
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet
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