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Mashup Score: 5JCI - Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis - 3 month(s) ago
Abstract Translocation Renal Cell Carcinoma (tRCC) most commonly involves an ASPSCR1-TFE3 fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we show that human ASPSCR1-TFE3 driven by Pax8-Cre (a credentialed ccRCC driver) disrupted nephrogenesis and glomerular development causing neonatal death, whilst the ccRCC failed driver, Sglt2-Cre, induced aggressive tRCC…
Source: www.jci.orgCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 97JCI - Molecular and cellular mechanisms underlying the failure of mitochondrial metabolism drugs in cancer clinical trials - 3 month(s) ago
As a mitochondrial ETC inhibitor, metformin should theoretically be toxic, but it has a high safety profile, which is attributed to its reliance on organic cation transporters (OCTs) for cellular entry (Figure 1). OCTs are highly abundant in normal kidney, gut, and liver cells and can transport various compounds, including polyamines, thiamine, carnitine, dopamine, and acetylcholine. When…
Source: www.jci.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 18JCI - Dietary potassium stimulates Ppp1Ca-Ppp1r1a dephosphorylation of kidney NaCl cotransporter and reduces blood pressure - 4 month(s) ago
Animals. Kinase-activating mutations were introduced into the SPAK gene, and expression of the CA form of SPAK was specifically targeted to the early DCT using parvalbumin-driven Cre recombinase (Parv-Cre) as previously described (43). For these studies, homozygous CA-SPAK mice (SPAK genotype: CA/CA, Parv-Cre–/+) and heterozygous CA-SPAK control mice (SPAK genotype: CA/–, Parv-Cre–/+) were…
Source: www.jci.orgCategories: General Medicine News, NephrologyTweet
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Mashup Score: 3
Standard treatment. Women with OC are typically approached with tumor cytoreductive surgery, involving removal of gynecologic organs (total abdominal hysterectomy, bilateral salpingo-oophorectomy), lymph nodes, and omentum followed by platinum (Pt)/taxane-based chemotherapy. Cytoreductive surgery that removes most of the tumor mass, leaving behind microscopic or less than 1 mm tumor implants, is…
Source: www.jci.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 16JCI - Cardiac noradrenergic deficiency revealed by 18F-dopamine positron emission tomography identifies preclinical central Lewy body diseases - 4 month(s) ago
Clinical MedicineIn-Press PreviewNeuroscience Open Access | 10.1172/JCI172460 Courtney Holmes,1 Patti Sullivan,1 Grisel Lopez,2 Janna Gelsomino,1 Sarah Moore,1 Risa Isonaka,1 Tianxia Wu,3 and Yehonatan Sharabi4 1Autonomic Medicine Section, Clinical Neurosciences Program, Division of Int, National Institute of…
Source: www.jci.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 494JCI - Leptin physiology and pathophysiology: knowns and unknowns 30 years after its discovery - 4 month(s) ago
Complete absence of leptin or its inability to signal, caused by loss-of-function mutations of the ligand or its receptor in both rodents and humans, respectively, produces profound obesity. Consistent with classic endocrine logic, leptin replacement reverses obesity due to leptin mutations but does not correct obesity caused by mutations in its receptor. Contrary to the initial idea of leptin…
Source: www.jci.orgCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 494JCI - Leptin physiology and pathophysiology: knowns and unknowns 30 years after its discovery - 4 month(s) ago
Complete absence of leptin or its inability to signal, caused by loss-of-function mutations of the ligand or its receptor in both rodents and humans, respectively, produces profound obesity. Consistent with classic endocrine logic, leptin replacement reverses obesity due to leptin mutations but does not correct obesity caused by mutations in its receptor. Contrary to the initial idea of leptin…
Source: www.jci.orgCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 18JCI - Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice - 5 month(s) ago
ResearchIn-Press PreviewNeuroscienceVascular biology Open Access | 10.1172/JCI166134 Russell H. Knutsen,2 Feiyang Ma,1 Ana Mompeón,1 Gloria E. Hernandez,1 Jocelynda Salvador,1 Snezana Mirkov,1 Ayush Batra,3 David P. Sullivan,4 Daniele Procissi,5 Samuel Buchanan,1 Elise Kronquist,2 Elisa A. Ferrante,6…
Source: www.jci.orgCategories: General Medicine News, General NewsTweet
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Mashup Score: 12JCI - Active DHEA uptake in the prostate gland correlates with aggressive prostate cancer - 5 month(s) ago
Research ArticleOncology Open Access | 10.1172/JCI171199 Zengming Wang,2 Shengsong Huang,3 Dongyin He,1 Weiwei Yan,1 Qian Zhuang,1 Zixian Wang,4 Chenyang Wang,3 Qilong Tan,1 Ziqun Liu,1 Tao Yang,3 Ying Liu,3 Ruobing Ren,5,6 Jing Li,7 William Butler,8 Huiru Tang,9 Gong-Hong…
Source: www.jci.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 8JCI - Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance - 5 month(s) ago
Research ArticleImmunologyOncology Open Access | 10.1172/JCI172919 Wei Si,3 Xianbin Yu,4 Andras Piffko,1,2,5 Xiaoyang Dou,4 Xingchen Ding,6 Jason Bugno,1,2,7 Kaiting Yang,1,2 Chuangyu Wen,1,2 Linda Zhang,4 Dapeng Chen,1,2 Xiaona Huang,1,2 Jiaai Wang,1,2 Ainhoa Arina,1,2 Sean Pitroda,1,2…
Source: www.jci.orgCategories: General Medicine News, General HCPsTweet
JCI - great effort in developing translocation renal cell carcinoma mouse model 🌟 a rare and deadly cancer🌟 https://t.co/cBigUZK1Gt