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Mashup Score: 8
Metastatic penile squamous cell carcinoma (PSCC) has only a 50% response rate to first-line combination chemotherapies and there are currently no targeted-therapy approaches. Therefore, we have an urgent need in advanced-PSCC treatment to find novel therapies. Approximately half of all PSCC cases ar …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 4Grants - Kidney Cancer Association - 2 month(s) ago
Kidney Cancer Association offers grants for research with impact. Learn more
Source: www.kidneycancer.orgCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 5JCI - Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis - 3 month(s) ago
Abstract Translocation Renal Cell Carcinoma (tRCC) most commonly involves an ASPSCR1-TFE3 fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we show that human ASPSCR1-TFE3 driven by Pax8-Cre (a credentialed ccRCC driver) disrupted nephrogenesis and glomerular development causing neonatal death, whilst the ccRCC failed driver, Sglt2-Cre, induced aggressive tRCC…
Source: www.jci.orgCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 0Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks - 3 month(s) ago
Interaction of CD27 on naive T cells with CD70 on antigen-presenting cells is necessary for T cell memory fate determination. Jaeger-Ruckstuhl et al. engineer a trimeric CD70-ligand and assess consequences of CD27 ligation on receptor regulation, early proximal signaling, transcriptional and epigenetic states, revealing how modulation of T cell activation by CD27 affects fate commitment and efficacy of T cell immunotherapy.
Source: www.cell.comCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 13Insufficiencies Discovered in Patient Reported Outcomes Data From Genitourinary Cancer Clinical Trials - The ASCO Post - 3 month(s) ago
By The ASCO Post Staff Posted: 2/7/2024 10:31:00 AM Last Updated: 2/7/2024 11:13:37 AM Investigators may have found a significant unmet need for improved analyses and reporting of patient-reported outcomes in genitourinary cancer clinical trials, according to a recent study published by Paravathaneni et al…
Source: ascopost.comCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 13Multiplex Immunofluorescence Captures Progressive Immune Exhaustion with Advancing Penile Squamous Cell Cancer Stage - PubMed - 3 month(s) ago
Penile squamous cell carcinoma (PSCC) is a rare and deadly malignancy. Therapeutic advances have been stifled by a poor understanding of disease biology. Specifically, the immune microenvironment is an underexplored component in PSCC and the activity of immune checkpoint inhibitors observed in a sub …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 44Melanoma and microbiota: Current understanding and future directions - 4 month(s) ago
Over the last decade, the composition of the gut microbiota has been found to correlate with the outcomes of cancer patients treated with immunotherapy. Accumulating evidence points to the various mechanisms by which intestinal bacteria act on distal tumors and how to harness this complex ecosystem to circumvent primary resistance to immune checkpoint inhibitors. Here, we review the state of the microbiota field in the context of melanoma, the recent breakthroughs in defining microbial modes of action, and how to modulate the microbiota to enhance response to cancer immunotherapy.
Source: www.cell.comCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 44Melanoma and microbiota: Current understanding and future directions - 4 month(s) ago
Over the last decade, the composition of the gut microbiota has been found to correlate with the outcomes of cancer patients treated with immunotherapy. Accumulating evidence points to the various mechanisms by which intestinal bacteria act on distal tumors and how to harness this complex ecosystem to circumvent primary resistance to immune checkpoint inhibitors. Here, we review the state of the microbiota field in the context of melanoma, the recent breakthroughs in defining microbial modes of action, and how to modulate the microbiota to enhance response to cancer immunotherapy.
Source: www.cell.comCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 40Melanoma and microbiota: Current understanding and future directions - 4 month(s) ago
Over the last decade, the composition of the gut microbiota has been found to correlate with the outcomes of cancer patients treated with immunotherapy. Accumulating evidence points to the various mechanisms by which intestinal bacteria act on distal tumors and how to harness this complex ecosystem to circumvent primary resistance to immune checkpoint inhibitors. Here, we review the state of the microbiota field in the context of melanoma, the recent breakthroughs in defining microbial modes of action, and how to modulate the microbiota to enhance response to cancer immunotherapy.
Source: www.cell.comCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 35Additivity predicts the efficacy of most approved combination therapies for advanced cancer - Nature Cancer - 6 month(s) ago
Palmer and colleagues present a computational model of drug additivity that can predict clinical efficacy for the majority of combination therapy trials in advanced cancer that led to US Food and Drug Administration approvals between 1995–2020.
Source: www.nature.comCategories: General Medicine News, Oncologists2Tweet
🚨🌟Transcriptomic, Proteomic, and Genomic Mutational Fraction Differences Based on HPV Status Observed in penile cancer PDX by @CurtisPettaway1 @MDAndersonNews @MoffittNews https://t.co/h8Yo7fXAWP