-
Mashup Score: 2Immune-Based and Novel Therapies in Variant Histology Renal Cell Carcinomas - PubMed - 14 hour(s) ago
Renal cell carcinoma (RCC) is a heterogeneous disease that represents the most common type of kidney cancer. The classification of RCC is primarily based on distinct morphological and molecular characteristics, with two broad categories: clear cell RCC (ccRCC) and non-clear cell RCC (nccRCC). Clear …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Oncologists1Tweet
-
Mashup Score: 39The Prognostic Role of HPV or p16INK4a Status in Penile Squamous Cell Carcinoma: A Meta-Analysis - 24 day(s) ago
Background: HPV infection is implicated in approximately half of global penile squamous cell carcinoma (PSCC) cases. Previous studies on HPV DNA and p16INK4a status in PSCC have yielded inconclusive prognostic findings. This meta-analysis aims to elucidate the prognostic role of HPV in PSCC by pooling data on disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS). Methods: We systematically searched Medline and Embase up to January 2023 for relevant human studies. Data from eligible publications reporting HPV DNA or p16INK4a status, along with and DFS, DSS, or OS outcomes, were extracted. A random-effects meta-analysis model was used to synthesize data, with study weights based on size and significance. The study protocol was registered with PROSPERO (CRD42019131355). Results: Out of 544 studies screened, 34 publications were included, comprising a pooled sample size of 3,944 patients. p16INK4a-positive status was associated with improved OS (hazard rat
Source: jnccn.orgCategories: General Medicine News, Oncologists1Tweet-
‼️🚨The best current evidence on the role of HPV in Penile Cancer: A Meta-Analysis by our group @MoffittNews @SpiessPhilippe @AnnaGiuliano19 @CurtisPettaway1 @MajdAssaad @HPVRoundtable @hsafaMD @StopHPVCancer @HPVAction @MaHPVCoalition @FightHPVcancer https://t.co/V9sIWXVKlw
-
-
Mashup Score: 8
Metastatic penile squamous cell carcinoma (PSCC) has only a 50% response rate to first-line combination chemotherapies and there are currently no targeted-therapy approaches. Therefore, we have an urgent need in advanced-PSCC treatment to find novel therapies. Approximately half of all PSCC cases ar …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Oncologists2Tweet-
🚨🌟Transcriptomic, Proteomic, and Genomic Mutational Fraction Differences Based on HPV Status Observed in penile cancer PDX by @CurtisPettaway1 @MDAndersonNews @MoffittNews https://t.co/h8Yo7fXAWP
-
-
Mashup Score: 4Grants - Kidney Cancer Association - 11 month(s) ago
Kidney Cancer Association offers grants for research with impact. Learn more
Source: www.kidneycancer.orgCategories: General Medicine News, Oncologists2Tweet-
RT @salvolarosa: Great working with @kaydaustin and @kidneycoa to build the future of #chrcc. Apply now at https://t.co/7I8eNoU07m
-
-
Mashup Score: 5JCI - Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis - 11 month(s) ago
Abstract Translocation Renal Cell Carcinoma (tRCC) most commonly involves an ASPSCR1-TFE3 fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we show that human ASPSCR1-TFE3 driven by Pax8-Cre (a credentialed ccRCC driver) disrupted nephrogenesis and glomerular development causing neonatal death, whilst the ccRCC failed driver, Sglt2-Cre, induced aggressive tRCC…
Source: www.jci.orgCategories: General Medicine News, Oncologists2Tweet-
JCI - great effort in developing translocation renal cell carcinoma mouse model 🌟 a rare and deadly cancer🌟 https://t.co/cBigUZK1Gt
-
-
Mashup Score: 0Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks - 12 month(s) ago
Interaction of CD27 on naive T cells with CD70 on antigen-presenting cells is necessary for T cell memory fate determination. Jaeger-Ruckstuhl et al. engineer a trimeric CD70-ligand and assess consequences of CD27 ligation on receptor regulation, early proximal signaling, transcriptional and epigenetic states, revealing how modulation of T cell activation by CD27 affects fate commitment and efficacy of T cell immunotherapy.
Source: www.cell.comCategories: General Medicine News, Oncologists2Tweet-
Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks: boosting cellular therapies https://t.co/GwKqVH51Qn
-
-
Mashup Score: 13Insufficiencies Discovered in Patient Reported Outcomes Data From Genitourinary Cancer Clinical Trials - The ASCO Post - 12 month(s) ago
By The ASCO Post Staff Posted: 2/7/2024 10:31:00 AM Last Updated: 2/7/2024 11:13:37 AM Investigators may have found a significant unmet need for improved analyses and reporting of patient-reported outcomes in genitourinary cancer clinical trials, according to a recent study published by Paravathaneni et al…
Source: ascopost.comCategories: General Medicine News, Oncologists2Tweet-
Thank you for @ASCO @ASCOPost for hilighting the work of super🌟 first year @bcmhouston fellow @hsafaMD and 2nd year fellow 🌟 @MParavathaneni @MoffittNews @MoffittHemOnc important work on PROMs from GU trials @eClinicalMed @MoffittGUOnc https://t.co/fEgg2rxfCI
-
-
Mashup Score: 13Multiplex Immunofluorescence Captures Progressive Immune Exhaustion with Advancing Penile Squamous Cell Cancer Stage - PubMed - 12 month(s) ago
Penile squamous cell carcinoma (PSCC) is a rare and deadly malignancy. Therapeutic advances have been stifled by a poor understanding of disease biology. Specifically, the immune microenvironment is an underexplored component in PSCC and the activity of immune checkpoint inhibitors observed in a sub …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Oncologists2Tweet-
🌟🍾Great effort from first year fellows🌟🌟@MoffittHemOnc @MoffittGUOnc @RomanSouzaMD #keerthiGullapali and senior fellow @FilipIonescu5 MIF Captures Progressive Immune Exhaustion with Advancing Penile Cancer. More coming w 👑 @SpiessPhilippe @GTumors https://t.co/dSuivTiXiU
-
-
Mashup Score: 44
Over the last decade, the composition of the gut microbiota has been found to correlate with the outcomes of cancer patients treated with immunotherapy. Accumulating evidence points to the various mechanisms by which intestinal bacteria act on distal tumors and how to harness this complex ecosystem to circumvent primary resistance to immune checkpoint inhibitors. Here, we review the state of the microbiota field in the context of melanoma, the recent breakthroughs in defining microbial modes of action, and how to modulate the microbiota to enhance response to cancer immunotherapy.
Source: www.cell.comCategories: General Medicine News, Oncologists2Tweet-
RT @Cancer_Cell: Online Now: Melanoma and microbiota: Current understanding and future directions https://t.co/HGIllqGwZH https://t.co/gUXm…
-
-
Mashup Score: 44
Over the last decade, the composition of the gut microbiota has been found to correlate with the outcomes of cancer patients treated with immunotherapy. Accumulating evidence points to the various mechanisms by which intestinal bacteria act on distal tumors and how to harness this complex ecosystem to circumvent primary resistance to immune checkpoint inhibitors. Here, we review the state of the microbiota field in the context of melanoma, the recent breakthroughs in defining microbial modes of action, and how to modulate the microbiota to enhance response to cancer immunotherapy.
Source: www.cell.comCategories: General Medicine News, Oncologists2Tweet-
RT @Cancer_Cell: Online Now: Melanoma and microbiota: Current understanding and future directions https://t.co/HGIllqGwZH https://t.co/gUXm…
-
🚨 A comprehensive review on Immune-Based and Novel Therapies in Variant Histology Renal Cell Carcinomas lead by super 🌟 @JMillerMed @MoffittResearch 🌟 https://t.co/vrrGB3CUvb