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Mashup Score: 3
Genome-wide association studies (GWAS) aim to identify common genetic variants that are associated with traits and diseases. Since 2005, more than 5,000 GWAS have been published for almost as many traits. These studies have offered insights into the loci and genes underlying phenotypic traits, highlighted genetic correlations across traits and diseases and are beginning to demonstrate clinical…
Source: Physiological ReviewsCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 0A Multisystem Physiological Perspective of Human Frailty and Its Modulation by Physical Activity | Physiological Reviews - 1 year(s) ago
“Frailty” is a term used to refer to a state characterised by enhanced vulnerability to, and impaired recovery from, stressors, when compared to a non-frail state, which is increasingly viewed as a loss of resilience. With increasing life expectancy and the associated rise in years spent with physical frailty, there is a need to understand the clinical and physiological features of frailty and…
Source: Physiological ReviewsCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 4A Multisystem Physiological Perspective of Human Frailty and Its Modulation by Physical Activity | Physiological Reviews - 1 year(s) ago
“Frailty” is a term used to refer to a state characterised by enhanced vulnerability to, and impaired recovery from, stressors, when compared to a non-frail state, which is increasingly viewed as a loss of resilience. With increasing life expectancy and the associated rise in years spent with physical frailty, there is a need to understand the clinical and physiological features of frailty and…
Source: Physiological ReviewsCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 10
Flexibly selecting appropriate actions in response to complex, ever-changing environments requires both cortical and subcortical regions, which are typically described as participating in a strict hierarchy. In this traditional view, highly specialized subcortical circuits allow for efficient responses to salient stimuli, at the cost of adaptability and context-specificity, which are attributed…
Source: Physiological ReviewsCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 11
Intestinal fibrosis is considered an inevitable complication of Crohn’s disease (CD) that results in symptoms of obstruction and stricture formation. Endoscopic or surgical treatment is required to treat the majority of patients. Progress in the management of stricturing CD is hampered by the lack of effective anti-fibrotic therapy; however, this situation is likely to change because of recent…
Source: Physiological ReviewsCategories: Gastroenterology, Latest HeadlinesTweet
Just out @physiolrev Genome-wide association studies of cardiovascular disease, by leaders in the field! Well done @JeanetteErdmann @cbezzina1 @roddywalsh @JurgensSean #GWAS #Cardiotwitter @Circ_Gen https://t.co/ORZn54MvZB https://t.co/SWzfkD8WRB