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Mashup Score: 11Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review - BMC Gastroenterology - 20 day(s) ago
Gastrointestinal Tuberculosis (GITB) and Crohn’s disease (CD) are both chronic granulomatous diseases with a predilection to involve primarily the terminal ileum. GITB is often considered a disease of the developing world, while CD and inflammatory bowel disease are considered a disease of the developed world. But in recent times, the epidemiology of both diseases has changed. Differentiating GITB from CD is of immense clinical importance as the management of both diseases differs. While GITB needs anti-tubercular therapy (ATT), CD needs immunosuppressive therapy. Misdiagnosis or a delay in diagnosis can lead to catastrophic consequences. Most of the clinical features, endoscopic findings, and imaging features are not pathognomonic for either of these two conditions. The definitive diagnosis of GITB can be clinched only in a fraction of cases with microbiological positivity (acid-fast bacilli, mycobacterial culture, or PCR-based tests). In most cases, the diagnosis is often based on co
Categories: General Medicine News, GastroenterologyTweet
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Mashup Score: 13NHLBI helps launch the first NIH National Commission on Lymphatic Diseases | NHLBI, NIH - 26 day(s) ago
The NHLBI helped launch the first-ever NIH National Commission on Lymphatic Diseases, which seeks to advance research for these poorly understood conditions.
Source: www.nhlbi.nih.govCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 30
Intestinal fibrosis is a common and serious complication of inflammatory bowel diseases (IBD) driving stricture formation in Crohn’s disease patients and leading to submucosal damage in ulcerative …
Source: www.tandfonline.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 5Home | AIBD Regionals - 2 month(s) ago
AIBD Regionals are a series of events designed for clinicians treating patients with IBD. Each meeting offers cutting-edge updates on positioning IBD therapies, real-world patient case examples, and pragmatic approaches to managing patient care. Choose from five different dates —virtual or in person—providing the flexibility to join when and where is most convenient to you. Don’t miss the chance to hear from our highly distinguished chairs and faculty as they share best practices and practical approache
Source: www.hmpglobalevents.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 10NHLBI helps launch the first NIH National Commission on Lymphatic Diseases | NHLBI, NIH - 2 month(s) ago
The NHLBI helped launch the first-ever NIH National Commission on Lymphatic Diseases, which seeks to advance research for these poorly understood conditions.
Source: www.nhlbi.nih.govCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 6
Objective This study aims to validate the existence of a microbiome within intraductal papillary mucinous neoplasm (IPMN) that can be differentiated from the taxonomically diverse DNA background of next-generation sequencing procedures. Design We generated 16S rRNA amplicon sequencing data to analyse 338 cyst fluid samples from 190 patients and 19 negative controls, the latter collected directly from sterile syringes in the operating room. A subset of samples (n=20) and blanks (n=5) were spiked with known concentrations of bacterial cells alien to the human microbiome to infer absolute abundances of microbial traces. All cyst fluid samples were obtained intraoperatively and included IPMNs with various degrees of dysplasia as well as other cystic neoplasms. Follow-up culturing experiments were conducted to assess bacterial growth for microbiologically significant signals. Results Microbiome signatures of cyst fluid samples were inseparable from those of negative controls, with no differ
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 5
Objective This study aims to validate the existence of a microbiome within intraductal papillary mucinous neoplasm (IPMN) that can be differentiated from the taxonomically diverse DNA background of next-generation sequencing procedures. Design We generated 16S rRNA amplicon sequencing data to analyse 338 cyst fluid samples from 190 patients and 19 negative controls, the latter collected directly from sterile syringes in the operating room. A subset of samples (n=20) and blanks (n=5) were spiked with known concentrations of bacterial cells alien to the human microbiome to infer absolute abundances of microbial traces. All cyst fluid samples were obtained intraoperatively and included IPMNs with various degrees of dysplasia as well as other cystic neoplasms. Follow-up culturing experiments were conducted to assess bacterial growth for microbiologically significant signals. Results Microbiome signatures of cyst fluid samples were inseparable from those of negative controls, with no differ
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 2Raymond Cross, MD: Define UC Disease Severity in Regard to Symptoms - 2 month(s) ago
Dr Cross reviews the highlights of his presentation on recommendations for initial diagnostics and treatment in the care of the hospitalized patient with ulcerative colitis.
Source: www.hmpgloballearningnetwork.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 4IBDHorizons – Advancing IBD Management - 3 month(s) ago
Success! We have received your activity evaluation and application for credit.When can I expect my credit? Please allow 4-6 weeks from the date of the event for processing.Who will I hear from? The Annenberg Center for Health Sciences at Eisenhower processes certificates and will email you once the certificate is issued.Will they email my certificate directly? No, they will email you instructions…
Source: ibdhorizons.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 88
Objective Intestinal fibrosis is considered an inevitable consequence of chronic IBD, leading to stricture formation and need for surgery. During the process of fibrogenesis, extracellular matrix (ECM) components critically regulate the function of mesenchymal cells. We characterised the composition and function of ECM in fibrostenosing Crohn’s disease (CD) and control tissues. Design Decellularised full-thickness intestinal tissue platforms were tested using three different protocols, and ECM composition in different tissue phenotypes was explored by proteomics and validated by quantitative PCR (qPCR) and immunohistochemistry. Primary human intestinal myofibroblasts (HIMFs) treated with milk fat globule-epidermal growth factor 8 (MFGE8) were evaluated regarding the mechanism of their antifibrotic response, and the action of MFGE8 was tested in two experimental intestinal fibrosis models. Results We established and validated an optimal decellularisation protocol for intestinal IBD tiss
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet
RT @drvishal82: Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review https://t.co/rCJno0fIs5