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Mashup Score: 2Therapeutic developments in pancreatic cancer - Nature Reviews Gastroenterology & Hepatology - 1 year(s) ago
The incidence of pancreatic ductal adenocarcinoma (PDAC) is rising. In this Review, Hu and O’Reilly summarize the latest advances and clinical trials for the treatment of PDAC, including biomarkers, targeted therapies and immunotherapy as well as novel clinical trial designs. They also discuss emerging therapeutic options for this disease.
Source: NatureCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 6The evolving story of apolipoprotein L1 nephropathy: the end of the beginning - Nature Reviews Nephrology - 1 year(s) ago
This Review summarizes current understanding of the role of APOL1 variants in kidney disease. The authors discuss the genetics, protein structure and biological functions of APOL1 variants and provide an overview of promising therapeutic strategies.
Source: NatureCategories: Latest Headlines, NephrologyTweet-
The evolving story of APOL1 nephropathy https://t.co/GYsh5y5CAJ https://t.co/SolTVL80Zt
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Mashup Score: 20
A paper in Nature finds that nuclear genetic variation can influence heteroplasmy and the human mitochondrial genome.
Source: NatureCategories: Future of Medicine, Latest HeadlinesTweet-
Human genetics: Nuclear genome influences mitochondrial DNA https://t.co/PU4IIybLTZ #ResearchHighlight by @haertl17
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Mashup Score: 8Epidemiology of the idiopathic inflammatory myopathies - Nature Reviews Rheumatology - 1 year(s) ago
In this Review, the authors present epidemiological data relating to the idiopathic inflammatory myopathies and summarize the current understanding of the risk factors associated with these conditions, as well as highlighting areas that require further research.
Source: NatureCategories: Latest Headlines, RheumatologyTweet-
Well done to my clinical fellow, Thomas Khoo @UniofAdelaide for a landmark review in @NatRevRheumatol on #myositis with global diverse authorship: Epidemiology of the idiopathic inflammatory myopathies @UoMMskResearch @NCAresearchNHS @ManchesterBRC https://t.co/P98rnjXxyF
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Mashup Score: 0Reduction in colorectal cancer incidence by screening endoscopy - Nature Reviews Gastroenterology & Hepatology - 1 year(s) ago
This Perspective explores the relationship between screening endoscopy and colorectal cancer incidence, examining available evidence and offering insights into the discrepancies between real-world and trial evidence alongside potential pitfalls with interpreting the data.
Source: NatureCategories: Gastroenterology, Latest HeadlinesTweet-
👩🏽🔬Online this week @NatRevGastroHep 🧵 3/5 "Reduction in colorectal cancer incidence by screening endoscopy" | a Perspective article: https://t.co/X9icyu8oPl
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Mashup Score: 6Association of metabolic dysfunction-associated fatty liver disease with kidney disease - Nature Reviews Nephrology - 1 year(s) ago
‘Metabolic dysfunction-associated fatty liver disease’ has been proposed as a replacement term for ‘Non-alcoholic fatty liver disease’, in part to recognize the fact that this liver disease occurs within a series of complex metabolic disorders. This Perspective article discusses the clinical associations and pathophysiological mechanisms underpinning the relationship between metabolic…
Source: NatureCategories: Latest Headlines, NephrologyTweet-
Association of metabolic dysfunction-associated fatty liver disease with kidney disease https://t.co/tNgnWSJb0H https://t.co/ZaPuIWOdOU
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Mashup Score: 2
In this Tools of the Trade article, Emmanuel Olivier describes an approach to reprogramming AML cancer cells into induced pluripotent stem cells, which provide faithful genetic models of the most common genetic subgroups of AML.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In this recent tools of the trade article, Emmanuel Olivier from the @PapapetrouMDPhD lab describes an approach to reprogram #AML cancer cells into iPSCs, which provide faithful genetic models of the most common genetic subgroups of AML. https://t.co/34ki9qPQKJ @SinaiStemCell
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Mashup Score: 0Nasopharyngeal cancer screening with an anti-BNLF2b antibody: a new arrow in the quiver? - Nature Reviews Clinical Oncology - 1 year(s) ago
Epstein–Barr virus (EBV)-based biomarkers are used for nasopharyngeal carcinoma (NPC) screening in endemic regions. A recent prospective study describes the use of a new serological biomarker, antibodies targeting the EBV protein BNLF2b, for NPC screening in >20,000 participants. This biomarker yielded both higher sensitivity and specificity for NPC detection in the screening cohort compared with…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In a News and Views now published online, Jacky Lam and Anthony Chan discuss the results of a recent intervention for population screening for nasopharyngeal cancer: https://t.co/xGpH8jRsRR https://t.co/Usy0i6jMgv
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Mashup Score: 0Diabetes mellitus in breast cancer survivors: metabolic effects of endocrine therapy - Nature Reviews Endocrinology - 1 year(s) ago
Evidence indicates an elevated risk of type 2 diabetes mellitus after breast cancer treatment, particularly for endocrine therapy. This Review outlines the evidence for adverse metabolic effects of endocrine therapies in humans. Potential mechanisms, informed by preclinical research, for the increased risk of type 2 diabetes mellitus are discussed.
Source: NatureCategories: Endocrinology, Latest HeadlinesTweet-
Enjoying Elizabeth Wellberg’s talk at #EASD2023? Check out her review here! https://t.co/N8jFZ4SMyy
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Mashup Score: 5Stress can be exhausting for T cells - Nature Reviews Immunology - 1 year(s) ago
Globig et al. report in Nature that the sympathetic nervous system can signal to T cells to promote T cell exhaustion.
Source: NatureCategories: Allergy-Immunology, Latest HeadlinesTweet-
NEW Highlight of @Nature paper by @AnnaGlobig @Tcellogic @salkinstitute reporting that the sympathetic nervous system can signal to T cells through ADRB1 to promote T cell exhaustion and that blocking ADRB1 synergizes with immune checkpoint blockade https://t.co/Fa0NpFjGqk https://t.co/GRwAz7Sr0g
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#ICYMI last week online @NatRevGastroHep 1/5🧵 "Therapeutic developments in pancreatic cancer" #Review | Read here: https://t.co/0sqtg7V37d