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Mashup Score: 1Antisense oligonucleotide–mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice - 3 year(s) ago
Supported by an abundance of experimental and genetic evidence, angiopoietin-like protein 3 (ANGPTL3) has emerged as a promising therapeutic target for cardiovascular disease. ANGPTL3 is primarily produced by the liver and is a potent modulator of plasma lipids and lipoproteins. Experimental models and subjects with loss-of-function Angptl3 mutations typically present with lower levels of HDL-C…
Source: Journal of Lipid ResearchCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 0Endothelial ether lipids link the vasculature to blood pressure, behavior, and neurodegeneration - 3 year(s) ago
Vascular disease contributes to neurodegeneration, which is associated with decreased blood pressure in older humans. Plasmalogens, ether phospholipids produced by peroxisomes, are decreased in Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative disorders. However, the mechanistic links between ether phospholipids, blood pressure, and neurodegeneration are not fully understood….
Source: Journal of Lipid ResearchCategories: Latest Headlines, NeurologyTweet-
Findings from Spears et al. suggest that endothelium-derived ether lipids mediate several biological processes and may also confer neuroprotection in mice. https://t.co/DiJTtxlah1 @WUSTL @WUSTLCellBio
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Mashup Score: 0Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection - 3 year(s) ago
Individuals with features of metabolic syndrome are particularly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus associated with the severe respiratory disease, coronavirus disease 2019 (COVID-19). Despite considerable attention dedicated to COVID-19, the link between metabolic syndrome and SARS-CoV-2 infection remains unclear. Using data from the…
Source: Journal of Lipid ResearchCategories: Allergy-Immunology, Latest HeadlinesTweet-
Association of serum HDL cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection https://t.co/EUPZP5wDA8 @KeckMedUSC
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Mashup Score: 0
The analysis of T cell lipid raft proteome is challenging due to the highly dynamic nature of rafts and the hydrophobic character of raft-resident proteins. We explored an innovative strategy for bottom-up lipid raftomics based on suspension-trapping (S-Trap) sample preparation. Mouse T cells were prepared from splenocytes by negative immunoselection, and rafts were isolated by a detergent-free…
Source: Journal of Lipid ResearchCategories: Allergy-Immunology, Latest HeadlinesTweet-
A sensitive S-Trap-based approach to the analysis of T cell lipid raft proteome – #Immunology #Lymphocytes #MassSpec #Raftomics https://t.co/QtSQOOBfN5 @Inserm
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Mashup Score: 0
The eicosanoids are a family of lipid mediators of pain and inflammation involved in multiple pathologies, including asthma, hypertension, cancer, atherosclerosis, and neurodegenerative diseases. These signaling mediators act locally, but are rapidly metabolized and transported to the systemic circulation as a mixture of primary and secondary metabolites. Accordingly, urine has become a useful…
Source: Journal of Lipid ResearchCategories: Allergy-Immunology, Latest HeadlinesTweet-
Quantitative metabolic profiling of urinary eicosanoids for clinical phenotyping – #MassSpec #Lipids #Eicosanoids #Prostaglandins #Inflammation #Asthma https://t.co/6xrF34lPcz @karolinskainst
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Mashup Score: 1Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting [S] - 3 year(s) ago
Lipid droplets (LDs) are energy-storage organelles that are coated with hundreds of proteins, including members of the perilipin (PLIN) family. PLIN5 is highly expressed in oxidative tissues, including the liver, and is thought to play a key role in uncoupling LD accumulation from lipotoxicity; however, the mechanisms behind this action are incompletely defined. We investigated the role of…
Source: Journal of Lipid ResearchCategories: Allergy-Immunology, Latest HeadlinesTweet-
"Hepatic PLIN5 signals via SIRT1 to promote #autophagy and prevent #inflammation during #fasting" https://t.co/CevOpEdGSl @UMNews @dgmashek
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Mashup Score: 0Lipid metabolism dysregulation in diabetic retinopathy - 3 year(s) ago
Julia V Busik
Source: Journal of Lipid ResearchCategories: Cardiologists, Latest HeadlinesTweet-
Lipid metabolism dysregulation in diabetic retinopathy https://t.co/ojVEtV7YE8 via @jlipidres @nationallipid @lipidboard #diabetes https://t.co/mJLX7Ed058
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Mashup Score: 0Tetracosahexaenoylethanolamide, a novel n-acylethanolamide, is elevated in ischemia and increases neuronal output - 3 year(s) ago
Lin Lin, Adam H Metherel, Mathieu Di Miceli, Zhen Liu, Cigdem Sahin, Xavier Fioramonti, Carolyn L. Cummins, Sophie Layé, Richard P. Bazinet
Source: Journal of Lipid ResearchCategories: Latest Headlines, NeurologyTweet-
Findings in @JLipidRes by Lin and Metherel et al. present THEA as a novel lipid-signaling molecule that regulates neuronal excitability in the mouse brain after ischemia. https://t.co/5USyFIfgh6 https://t.co/Na07w7gvlj
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Mashup Score: 0
Maria Podbielska, Zdzislaw M. Szulc, Toshio Ariga, Anna Pokryszko-Dragan, Wojciech Fortuna, Malgorzata Bilinska, Ryszard Podemski, Ewa Jaskiewicz, Ewa Kurowska, Robert K. Yu, Edward L Hogan
Source: Journal of Lipid ResearchCategories: Latest Headlines, NeurologyTweet-
"Distinctive sphingolipid patterns in chronic multiple sclerosis lesions" – #CNS #MultipleSclerosis #MS # Ceramides #MassSpec #Neurodegeneration https://t.co/tpjxxV13g6 @MUSChealth @MCG_AUG @AUG_University https://t.co/cJwD4bg03T
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Mashup Score: 0Tetracosahexaenoylethanolamide, a novel n-acylethanolamide, is elevated in ischemia and increases neuronal output - 4 year(s) ago
Lin Lin, Adam H Metherel, Mathieu Di Miceli, Zhen Liu, Cigdem Sahin, Xavier Fioramonti, Carolyn L. Cummins, Sophie Layé, Richard P. Bazinet
Source: Journal of Lipid ResearchCategories: Latest Headlines, NeurologyTweet-
Lin et al. present data that suggest tetracosahexaenoylethanolamide is produced in the brain upon ischemia/hypercapnia and regulates neuronal excitation. – #BrainLipids #Neuron #FattyAcid #Metabolism https://t.co/Pzk8IZHeEw @UofT @univbordeaux https://t.co/ULezeHtkEF
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Nice paper from @ionispharma led by Rosanne Crooke on ASO inhibiting ANGPTL3 and potentiating reverse cholesterol transport. ANGPTL3 ASO is in late stage 2B, could be the new kid on the block for residual high LDL/TGs https://t.co/l5wYaP1I0Z