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Mashup Score: 1Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis - 2 year(s) ago
Cerebrotendinous xanthomatosis (CTX) is caused by autosomal recessive loss-of-function mutations in CYP27A1, a gene encoding cytochrome p450 oxidase essential for bile acid synthesis, resulting in altered bile acid and lipid metabolism. Here, we aimed to identify metabolic aberrations that drive ongoing neurodegeneration in some patients with CTX despite chenodeoxycholic acid (CDCA)…
Source: Journal of Lipid ResearchCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 1A Tribute To Pete Ahrens - 2 year(s) ago
E. H. “Pete” Ahrens, Jr., a central figure in the history of this Journal, died on December 8, 2000, after a long battle with metastatic malignancy. Pete was the most eloquent and forceful of a number of individuals who, in the late 1950s, realized that better communication was needed among investigators of lipid metabolism and lipid biochemistry, and proposed the founding of this Journal. Time…
Source: Journal of Lipid ResearchCategories: Cardiologists, Latest HeadlinesTweet-
RT @thalesnemo: @DietHeartNews @LDLSkeptic https://t.co/sGSLnQPV40
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Mashup Score: 0Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish. - 2 year(s) ago
In Gaucher disease (GD), the deficiency of glucocerebrosidase causes lysosomal accumulation of glucosylceramide (GlcCer), which is partly converted by acid ceramidase to glucosylsphingosine (GlcSph) in the lysosome. Chronically elevated blood and tissue GlcSph is thought to contribute to symptoms in GD patients as well as to increased risk for Parkinson’s disease. On the other hand, formation of…
Source: Journal of Lipid ResearchCategories: Latest Headlines, NeurologyTweet-
To study the role of excessive GlcSph formation during glucocerebrosidase deficiency Lelieveld et al. studied zebrafish that have two orthologues of acid ceramidase, Asah1a and Asah1b — @UniLeiden @UniLeidenNews #neuroinflammation #gaucherdisease https://t.co/I98yKOSbhR
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Mashup Score: 0Hormone-sensitive lipase is localized at synapses and is necessary for normal memory functioning in mice - 2 year(s) ago
Hormone-sensitive lipase (HSL) is mainly present in adipose tissue where it hydrolyzes diacylglycerol. Although expression of HSL has also been reported in the brain, its presence in different cellular compartments is uncertain, and its role in regulating brain lipid metabolism remains hitherto unexplored. We hypothesized that HSL might play a role in regulating the availability of bioactive…
Source: Journal of Lipid ResearchCategories: Latest Headlines, NeurologyTweet-
Skoug et al. conclude that hormone-sensitive lipase (HSL) has a homeostatic role in maintaining pools of lipids required for normal brain function — @lunduniversity @Lundsuni @ceciliaskoug #lipidomics #neuro #metabolism https://t.co/YABsOToL0J
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Mashup Score: 1Cholesterol metabolism: from lipidomics to immunology - 2 year(s) ago
Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians for many decades, but their exact biological relevance in vivo, other than as intermediates in bile acid biosynthesis, has long been debated. However, in the first quarter of this century, a role for side-chain…
Source: Journal of Lipid ResearchCategories: Allergy-Immunology, Latest HeadlinesTweet-
#JLRReview | Cholesterol metabolism: from lipidomics to immunology | Here, Griffiths and Wang review recent findings related to the roles of oxysterols in immunology — @SwanseaMedicine #cholesterol https://t.co/PGR4KZ4BhL
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Mashup Score: 0Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism - 2 year(s) ago
Triglycerides are carried in the bloodstream as the components of very low-density lipoproteins and chylomicrons. These circulating triglycerides are primarily hydrolyzed in muscle and adipose tissue by the enzyme lipoprotein lipase (LPL). The activity of LPL is regulated by numerous mechanisms, including by three members of the angiopoietin-like protein family: ANGPTL3, ANGPTL4, and ANGPTL8. In…
Source: Journal of Lipid ResearchCategories: Allergy-Immunology, Latest HeadlinesTweet-
Sun et al.'s results collectively suggest that there existed an ancient lectin pathway in #molluscs, which was activated by a complement cascade to regulate the production of immune effectors, phagocytosis, and bacterial lysis — #DalianOceanUniversity https://t.co/kdeESueiNF
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Mashup Score: 0Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways - 2 year(s) ago
Leukotrienes (LTs) and sphingolipids are critical lipid mediators participating in numerous cellular signal transduction events and developing various disorders, such as bronchial hyperactivity leading to asthma. Enzymatic reactions initiating production of these lipid mediators involve 5-lipoxygenase (5-LO)-mediated conversion of arachidonic acid to LTs and serine palmitoyltransferase…
Source: Journal of Lipid ResearchCategories: Allergy-Immunology, Latest HeadlinesTweet-
Bugajev et al.'s results demonstrate functional crosstalk between the leukotriene and #sphingolipid metabolic pathways, leading to the production of lipid signaling mediators – @Akademie_ved_CR #TeamMassSpec https://t.co/YpgZnR7CIt
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Mashup Score: 0Hepatic lysosomal acid lipase overexpression worsens hepatic inflammation in mice fed a Western diet - 2 year(s) ago
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of lipid droplets in hepatocytes. NAFLD development and progression is associated with an increase in hepatic cholesterol levels and decreased autophagy and lipophagy flux. Previous studies have shown that the expression of lysosomal acid lipase (LAL), encoded by the gene LIPA, which can hydrolyze both triglyceride and…
Source: Journal of Lipid ResearchCategories: Allergy-Immunology, Latest HeadlinesTweet-
Lopresti et al. find that hepatic overexpression of LAL drove immune cell infiltration and inflammation and did not attenuate the development of NAFLD, suggesting that targeting LAL expression may not be a viable route to treat NAFLD in humans ― @dgmashek https://t.co/TCG7g0SSy9
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Mashup Score: 0Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways - 2 year(s) ago
Leukotrienes (LTs) and sphingolipids are critical lipid mediators participating in numerous cellular signal transduction events and developing various disorders, such as bronchial hyperactivity leading to asthma. Enzymatic reactions initiating production of these lipid mediators involve 5-lipoxygenase (5-LO)-mediated conversion of arachidonic acid to LTs and serine palmitoyltransferase…
Source: Journal of Lipid ResearchCategories: Allergy-Immunology, Latest HeadlinesTweet-
Bugajev et al.'s results demonstrate functional crosstalk between the leukotriene and #sphingolipid metabolic pathways, leading to the production of lipid signaling mediators – @Akademie_ved_CR #TeamMassSpec #immunology https://t.co/ldFbiLK0hQ
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Mashup Score: 1Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades - 2 year(s) ago
During the last 80 years there have been extraordinary advances in our knowledge of the chemistry and biology of bile acids. We present here a brief history of the major achievements as we perceive them. Bernal, a physicist, determined the X-ray structure of cholesterol crystals, and his data together with the vast chemical studies of Wieland and Windaus enabled the correct structure of the…
Source: Journal of Lipid ResearchCategories: Latest Headlines, Oncologists1Tweet-
Is there anything more apropos after Thanksgiving 🦃 🥘 than to read a definitive review on bile acid biochemistry @jlipidres? Or at least take delight in this figure on stereochemistry of 5-beta vs -alpha reduction w/most bile acids (R) vs. DHT (L, flat)? https://t.co/ojMrxqEXwf https://t.co/QAj3oAUCzQ
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"Metabolic profiling in serum, cerebrospinal fluid and brain of patients with Cerebrotendinous xanthomatosis" – #BileAcid #Metabolism #Cholesterol #CSF #TeamMassSpec https://t.co/KGtZ17uGqF @uni_tue