Since the declaration of war on cancer five decades ago to the recent establishment of the National Cancer Institute’s RAS initiative, biophysics has played a prominent role in addressing fundamental questions related to tumor formation, growth, and migration. Among the many critical contributions of experimental and computational…
Tumor-associated macrophages (TAMs) are well known to fuel tumor evolution. Blériot et al. advocate for integrating the time dimension when conceptualizing macrophage diversity in pre-malignancy and cancer…
Tumor-associated macrophages (TAMs) are well known to fuel tumor evolution. Blériot et al. advocate for integrating the time dimension when conceptualizing macrophage diversity in pre-malignancy and cancer…
Using the reconstituted presynaptic terminal local vesicle transport as a paradigm, Qiu and Wu et al. demonstrate that short-distance and directional vesicle transport can be achieved…
Cells carrying a monoallelic germline BRCA2 mutation can bypass Knudson’s “two-hit” requirement to initiate tumorigenesis when the glycolytic metabolite methylglyoxal transiently disables BRCA2 function. Metabolic…
This study explores the transformative power of big data in materials science, tackling the long-standing issue of data harnessability. The authors introduce a one-step approach…
Materials chemistry; Energy materials
The flexible scaffold-based cheminformatics approach (FSCA) unlocks the potential of drug design to create polypharmacological drugs that open up treatment possibilities for complex brain disorders.
Cancer-associated fibroblasts (CAFs) exhibit spatial and functional diversity. Here, Niu et al. unveil SETD2’s function in lipid metabolism and CAF heterogeneity in pancreatic ductal adenocarcinoma. SETD2…
In CO2 electrolyzers, balancing water and cations is vital. Through operando wide-angle scattering and fluorescence X-ray techniques, we observed H2O and Cs+ dynamics in the…
Despite deep knowledge of how the immune system works, many questions remain difficult to answer within the current core framework of innate and adaptive immunity.…
