Preventing escape from neutralizing antibodies
Convalescent plasma (CP) and monoclonal antibodies (mAbs), two approaches being evaluated for COVID-19 therapy, are vulnerable to antibody-resistance mutations…
Convalescent plasma (CP) and monoclonal antibodies (mAbs), two approaches being evaluated for COVID-19 therapy, are vulnerable to antibody-resistance mutations…
Nature Reviews Immunology – Here, Rongbin Zhou and colleagues review the different types of damage-associated molecular pattern (DAMP) that trigger sterile inflammation via pattern recognition…
Nature Reviews Immunology – A preprint by Yi et al. shows a role for the FAS signalling pathway in controlling the persistence of CAR-modified lymphocytes.
Nature Reviews Immunology – Wei et al. report a role for membrane perforation mediated by gasdermin D pores in disruption of the blood–brain barrier.
Nature Reviews Immunology – A preprint by Yi et al. shows a role for the FAS signalling pathway in controlling the persistence of CAR-modified lymphocytes.
Yi et al. (BioRxiv) DOI:10.1101/2024.02.26.582108 In this preprint, Yi et al. investigate the relationship between CAR-T cell persistence and the FAS/FAS-ligand (FAS-L) signaling pathway. The…
Chimeric antigen receptor (CAR)-engineered T and NK cells can cause durable remission of B-cell malignancies; however, limited persistence restrains the full potential of these therapies…
Nature Reviews Immunology – Adrian Liston, professor of pathology at the University of Cambridge, UK, has published several illustrated children’s books on the topic of…
Nature Reviews Immunology – Sex hormones in male mice negatively regulate type 2 innate lymphoid cells in the skin, impairing the induction and activation of…
Nature Reviews Immunology – Genome editing approaches can be used to confer immune-evasive properties to allogeneic cellular immunotherapies, with the aim of achieving persistent responses…
Nature Reviews Immunology – This Review discusses the mechanisms by which common alterations of cancer cell metabolism interfere with immune functions to promote immunoevasion and…