2024-mar-yi
Yi et al. (BioRxiv) DOI:10.1101/2024.02.26.582108 In this preprint, Yi et al. investigate the relationship between CAR-T cell persistence and the FAS/FAS-ligand (FAS-L) signaling pathway. The authors first constructed a single-cell atlas of immune and non-immune cells from healthy donors and patients with diverse cancer types, and highlight that while FAS is expressed by various immune and stromal cells, FASLG (the gene encoding FAS-L) is highly restricted to T and NK cells. In addition, using RNA in