Marsman et al. detect histone H1 in MRSA in human abscesses and demonstrate that it kills MRSA under physiological conditions. They identify through selective evolution and a genome-wide screen that histone H1 targets wall teichoic acids and permeabilizes potentiated membranes of metabolically active and dividing cells, providing molecular insight into host-mediated clearance of MRSA.
A gallery of portraits of prominent alumnae of color at Harvard Medical School provides inspiration for diverse current students and makes past sexist practices visible…
In the analysis, 34.7% of commercially insured patients with chronic obstructive pulmonary disease or asthma received an influenza vaccination.
When it comes to satisfying your sweet tooth, some sweeteners are better than others. What makes sugar a risk for your health, and what are…
STK19 functions in transcription-coupled DNA repair, aiding the clearance of RNAPII and advancing the repair process by positioning the ATPase subunits of TFIIH onto DNA.
Pathogenic protein aggregation drives Alzheimer’s disease, but how it is initiated remains unclear. By generating a APOE-HaloTag knockin mouse model and optimizing APOE purification techniques, Kaji…
Despite aging being one of the strongest risk factors for cancer, little is known about the biological mechanisms that promote tumor initiation. In this issue…
Sousa et al. characterized, with time and single-cell resolution, the immune environment of the regenerating skeletal muscle, revealing a profound remodeling of myeloid and lymphoid compartments…
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Objective Parents and caregivers of children with neurological conditions express interest in new and developing treatments and trials; however, they have limited knowledge of, and…
