Science Immunology Volume 8|Issue 81|Mar 2023 ONLINE COVER Glycoengineering the Tip of the Spear. This month’s cover depicts cellular soldiers (blue myeloid cells at the left and green T cells at the right) rushing to battle cancer cells. Leading the charge is an Fc-enhanced form of an anti–PD-L1 checkpoint blockade antibody. Using mice humanized to express human Fcγ…
Targeting PD-1+ cells promotes immune tolerance via peripheral clonal deletion of antigen-specific T cells.
A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-γ, granzymes, and perforin in bone marrow.
Targeting of GALT by anti-α4β7 therapy is associated with therapeutic responses in ulcerative colitis.
A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-γ, granzymes, and perforin in bone marrow.
Allogeneic CAR-DNTs with minimal genetic modification show potent anti-tumor activity without off-tumor toxicities.
Spatially resolved profiling of the melanoma microenvironment reveals correlates of response to immune checkpoint inhibitors.
Targeting of GALT by anti-α4β7 therapy is associated with therapeutic responses in ulcerative colitis.
The transcriptional regulator Trim33 controls Flt3L-driven dendritic cell differentiation.
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
The transcriptional regulator Trim33 controls Flt3L-driven dendritic cell differentiation.
