In-depth proteomic profiling of oocytes and early embryos in humans and mice reveals divergent protein behaviors during early development. Single-embryo proteomic analysis of poor-quality embryos from over 100 patient couples offers insights into human preimplantation development failure.
Transcriptome-wide mapping of snoRNA targets reveals mRNA-snoRNA-7SL RNA ternary interactions, which facilitate nascent protein translocation to the ER and subsequent secretion.
The impact of repeated peripheral viral infection on brain-resident adaptive immune cells is poorly understood. Utilizing mouse models of repetitive viral infection, Mix et al. demonstrate…
Jaschke and Wang review the current understanding of leukocyte compartmentalization in homeostasis and upon organismal stress, how neuroendocrine signals organize this trafficking, and the mechanisms…
The approval marks the first subcutaneous infusion device approved for the treatment of Parkinson disease, providing a new option for patients with serious disease who…
The diagnostic identifies patients who may be eligible for treatment with fam-trastuzumab-deruxtecan-nxki (Enhertu; Daiichi-Sankyo, AstraZeneca).
Specialized fibroblastic reticular cells (FRCs) underpin interconnected T cell environments with dedicated microenvironmental niches for FRC-T cell interaction, which promotes antitumor immunity in both human lung…
Despite its range of disease associations, Epstein-Barr virus (EBV) treatments or vaccines are lacking. Joyce et al. determined EBV gp350 structures complexed with either its human…
Enteric viral infections are a major public health problem in newborns. Ramirez Reyes et al. find that the immature intestinal epithelium of newborn mice is developmentally…
Health care professionals, particularly pharmacists, can recommend that patients take over-the-counter supplements, such as melatonin, to facilitate REM sleep.
World Cancer Day, observed annually on February 4th, is a global initiative aimed at raising awareness, reducing stigma, and promoting equitable access to cancer care,…
