Cognate antigen engagement induces HIV-1 expression in latently infected CD4+ T cells from people on long-term antiretroviral therapy
The relationship between antigen recognition and HIV-1 gene expression is unclear. Moskovjlevic et al. reveal that CD4+ T cell antigen recognition can drive HIV-1 transcription in individuals on ART. Antigen presentation induces T cell activation and promotes viral expression from rare cells, providing insights into spontaneous reservoir transcriptional activity and its potential contribution to viral rebound if therapy is interrupted.
