CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment
In skin injury, the inflammatory environment can impact repair mediated by skin stem cells. Luan, Truong, Vuchkovska, et al. show that hair follicle stem cells migrate into the wound, activate immune-modulatory molecules, and expand extrathymic regulatory T cells to facilitate the resolution of neutrophil responses and the initiation of wound repair.