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Mashup Score: 6
To our knowledge, this is the largest trial of a tricyclic antidepressant in IBS ever conducted. Titrated low-dose amitriptyline was superior to placebo as a second-line treatment for IBS in primary care across multiple outcomes, and was safe and well tolerated. General practitioners should offer low-dose amitriptyline to patients with IBS whose symptoms do not improve with first-line therapies, with appropriate support to guide patient-led dose titration, such as the self-titration document developed for this trial.
Source: www.thelancet.comCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 5British Society of Gastroenterology guidelines on sedation in gastrointestinal endoscopy - 7 month(s) ago
Over 2.5 million gastrointestinal endoscopic procedures are carried out in the United Kingdom (UK) every year. Procedures are carried out with local anaesthetic r with sedation. Sedation is commonly used for gastrointestinal endoscopy, but the type and amount of sedation administered is influenced by the complexity and nature of the procedure and patient factors. The elective and emergency nature of endoscopy procedures and local resources also have a significant impact on the delivery of sedation. In the UK, the vast majority of sedated procedures are carried out using benzodiazepines, with or without opiates, whereas deeper sedation using propofol or general anaesthetic requires the involvement of an anaesthetic team. Patients undergoing gastrointestinal endoscopy need to have good understanding of the options for sedation, including the option for no sedation and alternatives, balancing the intended aims of the procedure and reducing the risk of complications. These guidelines were
Source: gut.bmj.comCategories: Gastroenterology, Latest HeadlinesTweet-
RT @AndrewOngML: https://t.co/653vVSVPBE New @BritSocGastro guidelines on endoscopy sedation! Guidance on 💪Type of sedation 💪Pre-assessm…
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Mashup Score: 0
oach and Results: Patients with NAFLD from Australia and Spain who were followed for up to 28 years formed derivation (n = 584) and validation (n = 477) cohorts. Competing risk regression and information criteria were used for model development. Accuracy was compared with fibrosis models using time-dependent AUC analysis. During follow-up, LREs occurred in 52 (9%) and 11 (2.3%) patients in derivation and validation cohorts, respectively. Age, type 2 diabetes, albumin, bilirubin, platelet count, and international normalized ratio were independent predictors of LRE and were combined into a model [NAFLD outcomes score (NOS)]. The NOS model calibrated well [calibration slope, 0.99 (derivation), 0.98 (validation)] with excellent overall performance [integrated Brier score, 0.07 (derivation) and 0.01 (validation)]. A cutoff ≥1.3 identified subjects at a higher risk of LRE, (sub-HR 24.6, p < 0.001, 5-year cumulative incidence 38% vs 1.0%, respectively). The predictive accuracy at 5 and 10 yea
Source: journals.lww.comCategories: Gastroenterology, Latest HeadlinesTweet-
#HEP_highligths NOS-tradamus: Predicting hepatic decompensation and HCC in NAFLD 👨⚕️🧪 Calzadilla-Bertot et al. NAFLD Outcome Score (NOS) to predict liver events, minimizing “grey area” in current NITs. 📊 NOS: age, diabetes, alb, bili, plt, INR w/AUC 0.92 https://t.co/d0YBGpxNtB https://t.co/1riRnpzgqT
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Mashup Score: 3Fecal transplant ‘not over yet’ for C. difficile despite boom in live microbiota therapies - 7 month(s) ago
Clostridioides difficile infection presents a unique treatment paradox for clinicians: Antibiotics are often both its cause and its cure.The broad-spectrum antibiotics doled out to treat infections also radically alter the composition of the microbiota, wiping out a significant portion of the bacterial community and upsetting the natural balance of gut flora. Without competition from healthy
Source: www.healio.comCategories: Gastroenterology, Latest HeadlinesTweet-
In @GoHealio #GI’s latest cover story 📰, experts across the field discussed the shift in #Cdiff treatment and potential risks new therapies that have yet to been explored. Read the full story at the 🔗below👇🏻 #GITwitter #MedTwitter https://t.co/VA9H0FVy7e
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Mashup Score: 1FMT future ‘still being written,’ ideally with more options for recurrent C. difficile - 7 month(s) ago
From the early days of homemade “poop shakes” blended in a backroom 15 years ago to the current world of FDA-approved live biotherapeutic products, it feels like we are at an inflection point with fecal microbiota transplantation.With credit to Robert Hunter, collaborator and lyricist for the Grateful Dead: “What a long, strange trip it’s been.”
Source: www.healio.comCategories: Gastroenterology, Latest HeadlinesTweet-
“The future of #FMT is still being written,” @DrStollman said in response. “I greet that future with a great deal of optimistic excitement, but still with a bit of trepidation.” Read the full expert editorial here 👇🏻 https://t.co/gkdkkZPXSO
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Mashup Score: 1Cancer Survivorship Summit - 7 month(s) agoSource: YouTubeCategories: Gastroenterology, Latest HeadlinesTweet
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Listen now! ACG President Dr. Daniel Pambianco delivers a speech at the @RepDWSTweets Cancer Survivorship Summit: https://t.co/3ZEJj5Myy3 https://t.co/kCR40HGtTy
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Mashup Score: 0Application for SAGES Guidelines Fellow - SAGES - 7 month(s) ago
Application information and job description for the SAGES Guidelines Development Fellow with a deadline of November 1st, 2023.
Source: www.sages.orgCategories: Gastroenterology, Latest HeadlinesTweet-
SAGES is accepting candidates for the SAGES Guidelines Development Fellow position to start on July 1, 2024. Applications will be accepted until November 15th. Information and the application are at: https://t.co/txW7jS5P31
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Mashup Score: 0Long-term outcome of cervical lymph node metastasis in superficial pharyngeal squamous cell carcinoma after endoscopic submucosal dissection - 7 month(s) ago
Post written by Daisuke Kikuchi, MD, PhD, from the Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan. We evaluated the risk factors of cervical lymph node metastasis (LNM) in 33…
Source: endoscopedia.comCategories: Gastroenterology, Latest HeadlinesTweet-
New on the official blog of GIE, VideoGIE, and iGIE: "Long-term outcome of cervical lymph node metastasis in superficial pharyngeal squamous cell carcinoma after endoscopic submucosal dissection" by Daisuke Kikuchi https://t.co/5CiyDLDcrp https://t.co/Yb7BbwUU3O
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Mashup Score: 5Key landmarks to be documented and photographed during colonoscopy - 7 month(s) ago
Photo-documentation is a part of any endoscopic procedure. Photo-documentation helps patients understand what the physician saw and did during an endoscopy, and it is also helpful to other physicians reviewing the procedure note at a later date. In addition, photo-documentation provides physicians with proof of the extent of their examination and any maneuvers they performed, which is valuable in a variety of medical and legal situations. Most gastroenterologists receive limited education in their training on exactly what photographs to obtain, and in what order to obtain them, during endoscopy.
Source: www.giejournal.orgCategories: Gastroenterology, Latest HeadlinesTweet-
In Top Tips, Dominitz details "Key landmarks to be documented and photographed during colonoscopy." https://t.co/PR1MMEjyA1 @JasonDominitz @DarylRamai https://t.co/g1KVj64YIU
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Mashup Score: 0
All doses of ABX464 significantly improved moderate-to-severe, active ulcerative colitis compared with placebo, as measured by changes in MMS from baseline to week 8. A phase 3 clinical programme is ongoing.
Source: www.thelancet.comCategories: Gastroenterology, Latest HeadlinesTweet-
#UEGWeek Severine Vermeire presented data from the 96-week open label extension study of obefazimod, showing promising durability from the 48-week data published in our journal last year👇https://t.co/xqfNHWoeSK
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New online @TheLancet - Amitriptyline at Low-Dose and Titrated for #IBS as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial Catch the #UEGWeek presentation this pm by @alex_ford12399 https://t.co/R0GOVRv3s7