Overexpression of transposable elements is a common feature of cancer. Sun, You, et al. show that, in pancreatic ductal adenocarcinoma, tumor cells adapt through different mechanisms to mitigate a specific group of dsRNA-producing repeats in a TP53-dependent manner. Their work provides insight into how cancer cells escape the innate immune pressure elicited by repeat expression.
Analysis of 27,810 patients with advanced cancers treated with anti-PD-1/L1 therapies shows that immune gene signatures or immune cell infiltration is not universally associated with…
Loss-of-function mutations in LTBR result in a stromal defect, leading to dysfunctional secondary lymphoid organs and combined immunodeficiency in humans.
A large-scale proteomics study involving 53,026 individuals maps 2,920 plasma proteins to 406 prevalent diseases, 660 incident diseases, and 986 health-related traits, identifying promising biomarkers…
The American Association of Immunologists (AAI) is one of the world’s largest organizations of immunologists and scientists in related disciplines. Our mission is to improve…
Patterns, an open-access journal, has issued a call for novel data science research that could drive urban sustainability
“A blog about allergy, asthma & immunology”
Climate change influences the timing, duration, and intensity of the pollen season, impacting increasing numbers of people with allergies.
Hamidi et al. report the molecular profiling of 2,803 urothelial carcinoma tumors from four randomized clinical trials evaluating the PD-L1 inhibitor atezolizumab. Machine learning identifies four…
DALLAS — In this video from the American Association of Hip and Knee Surgeons Annual Meeting, Robert A. Burnett, MD, discussed results that showed repeat…
Hlavaty et al. demonstrate that, when cancer cells with high expression of ACSS1 are exposed to acetate, it causes significant metabolic rewiring that promotes cancer cell…
