Association of Pick’s disease with the MAPT H2 haplotype
One of the main players in the pathogenesis of neurodegenerative diseases is the microtubule-associated protein tau. Tau aggregation is involved in Alzheimer’s disease, in which it co-occurs with amyloid pathology, and in primary tauopathies (including frontotemporal dementia, progressive supranuclear palsy, or corticobasal degeneration), in which aggregation can occur in neurons or glial cells. Yet, despite some overlap, these diseases differ strikingly from each other clinically, with a spectrum of symptoms including behavioural changes, executive dysfunction, language or memory impairment, and extrapyramidal features.