Summary The Artificial Intelligence-based structure prediction program AlphaFold-Multimer enabled structural modelling of protein complexes with unprecedented accuracy. Increasingly, AlphaFold-Multimer is also used to discover new protein-protein interactions. Here, we present AlphaPulldown , a Python package that streamlines protein-protein interaction screens and high-throughput modelling of…
The transformation of fibroblasts into epithelial cells is critical for iPSC reprogramming. In this report, we describe studies with PFI-3, a small molecule inhibitor that…
Maize is currently the most productive cereal crop in the world (www.faostat.org). It can associate with the Arbuscular Mycorrhizal Fungus (AMF) Rhizophagus irregularis which can…
Alz-5 acts as a bifunctional chelator that can interact with various Ab aggregates and reduce their neurotoxicity. Single-cell ROS measurements provided by Pt-nanoelectrode technique revealed…
To verify the parasitic lifestyle of Candidatus Patescibacteria in the enrichment cultures derived from a methanogenic bioreactor, we applied multifaceted approaches combining cultivation, microscopy, metatranscriptomic,…
Focal adhesions (FAs) form the junction between extracellular matrix (ECM)-bound integrins and the actin cytoskeleton and also transmit signals that regulate cell adhesion, cytoskeletal dynamics,…
Rare cell populations are key in neoplastic progression and therapeutic response, offering potential intervention targets.However, their computational identification and analysis often lag behind major cell…
This research focuses on the investigation of the propagation of frequencies between 0.1 and 2.5 THz through a phantom ear model using terahertz (THz) time-domain…
In the following research, a novel antifungal culture method was discussed with the aim of developing bacterial culture media in which fungal growth is inhibited…
When a population is isolated and composed of few individuals, genetic drift is the paramount evolutionary force. Inbreeding might also occur, resulting in genomic regions…
Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca2+ into β-cells triggers insulin release. Since genetics strongly influences variation…
