Aβ-affine bifunctional copper chelators capable of Aβ-induced oxidative stress reduction and amyloid disaggregation

Alz-5 acts as a bifunctional chelator that can interact with various Ab aggregates and reduce their neurotoxicity. Single-cell ROS measurements provided by Pt-nanoelectrode technique revealed a significant antioxidant properties of Alz-5 in Ab42 – affected SH-SY5Y cell. AFM data obtained on Ab42 fibrils clearly indicate an anti-aggregating property of Alz-5. Young modulus mapping on living…

Read the full article here

Related Articles