Mashup Score:34
bioRxiv# biorxiv
Mashup Score:28
bioRxivIntravenous gene transfer throughout the brain of infant Old World primates using AAV - 1 week
Mashup Score:28
Adeno-associated viruses (AAVs) can enable robust and safe gene delivery to the mammalian central nervous system (CNS). While the scientific community has developed numerous...
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Intravenous gene transfer throughout the brain of infant Old World primates using AAV https://t.co/BwFnqZ2Zej #bioRxiv - view on twitter
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Mashup Score:28
bioRxivPrecise DNA Cloning via PAMless CRISPR-SpRYgests - 1 week
Mashup Score:28
While restriction enzymes (REs) remain the gold-standard for manipulating DNA in vitro, they have notable drawbacks including a dependence on short binding motifs that...
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Precise DNA Cloning via PAMless CRISPR-SpRYgests https://t.co/4Wjm4VNQpQ #bioRxiv - view on twitter
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Mashup Score:20
bioRxivA split ribozyme that links detection of a native RNA to orthogonal protein outputs - 7 days
Mashup Score:20
Individual RNA remains a challenging signal to synthetically transduce into different types of cellular information. Here, we describe Ribozyme-ENabled Detection of RNA (RENDR), a...
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A split ribozyme that links detection of a native RNA to orthogonal protein outputs https://t.co/vpMDKCYmZQ #bioRxiv - view on twitter
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Mashup Score:19
bioRxivCut-and-Paste DNA Insertion with Engineered Type V-K CRISPR-associated Transposases - 1 week
Mashup Score:19
CRISPR-associated transposases (CASTs) enable recombination-independent, multi-kilobase DNA insertions at RNA-programmed genomic locations. Type V-K CASTs offer distinct technological advantages over type I CASTs given...
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Cut-and-Paste DNA Insertion with Engineered Type V-K CRISPR-associated Transposases https://t.co/BxD25H5kDU #bioRxiv - view on twitter
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Mashup Score:19
bioRxivRapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons - 6 days
Mashup Score:19
Auxin-inducible degrons are a chemical genetic tool for targeted protein degradation and are widely used to study protein function in cultured mammalian cells. Here...
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Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons https://t.co/TxMzAyKGQr #bioRxiv - view on twitter
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Mashup Score:18
bioRxivTranscription shapes 3D chromatin organization by interacting with loop-extruding cohesin complexes - 1 week
Mashup Score:18
Cohesin organizes mammalian interphase chromosomes by reeling chromatin fibers into dynamic loops (Banigan and Mirny, 2020; Davidson et al., 2019; Kim et al., 2019;...
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Transcription shapes 3D chromatin organization by interacting with loop-extruding cohesin complexes https://t.co/5V9RC9iWnX #bioRxiv - view on twitter
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Mashup Score:18
bioRxivMEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas - 7 days
Mashup Score:18
Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma, namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors, and targeted immunotherapies, may offer an improved survival benefit...
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MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas https://t.co/PakQEMrhGQ #bioRxiv - view on twitter
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bioRxivMechanics of human embryo compaction - 1 week
Mashup Score:16
The shaping of the human embryo begins with compaction, during which cells come into close contact and form a tighter structure. Assisted reproductive technology...
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Mechanics of human embryo compaction https://t.co/yJVtrVeP1T #bioRxiv - view on twitter
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Mashup Score:16
bioRxivAmyloid-β plaques and neurofibrillary tau tangles are the neuropathologic hallmarks of Alzheimer’s disease (AD), but the spatiotemporal cellular responses and molecular mechanisms underlying AD...
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Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in an Alzheimer's disease model https://t.co/sGpd43bsBN #bioRxiv - view on twitter
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Aging manifests as progressive dysfunction culminating in death. The diversity of cell types is a challenge to the precise quantification of aging and its...
Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain https://t.co/vx0dpbfUDS #bioRxiv - view on twitter