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Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images

posted 12 hours

Mashup Score: 5

bioRxiv - Super-resolution structured illumination microscopy (SR-SIM) pro- vides an up to two-fold enhanced spatial resolution of fluorescently labeled samples. The reconstruction of high quality SR-SIM...

Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model

posted 5 hours

Mashup Score: 5

bioRxiv - The outbreak of coronavirus disease 2019 (COVID-19) rapidly spreads across worldwide and becomes a global pandemic. Remdesivir is the only COVID-19 treatment approved by...

bioRxiv - N6-methyladenosine (m6A) is the most common modification on endogenous RNA transcripts in mammalian cells. Currently, the lack of precise single-nucleotide RNA modification tools makes...

  • Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase https://t.co/kUuzYMx4OS #bioRxiv

bioRxiv - In humans and nonhuman primates, Mycobacterium tuberculosis lung infection yields a complex multicellular structure: the tuberculosis granuloma. All granulomas are not equivalent, however, even...

  • Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control https://t.co/EAVF8PpuSm #bioRxiv

DNA-loop extruding SMC complexes can traverse one another in vivo

posted 12 hours

Mashup Score: 3

bioRxiv - The spatial organization of chromosomes by structural maintenance of chromosomes (SMC) complexes is vital to organisms from bacteria to humans. SMC complexes were recently...

bioRxiv - Mycobacteria tuberculosis (Mtb) remains the deadliest pathogenic bacteria worldwide. The search for new antibiotics to treat drug-sensitive as well as drug-resistant tuberculosis has become...

  • Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis https://t.co/ZpYuRpzH2R #bioRxiv

A novel equilibrative nucleoside transporter 1 inhibitor alleviates Tau-mediated neurodegeneration

posted 2 days

Mashup Score: 3

bioRxiv - Tau hyperphosphorylation favors the formation of neurofibrillary tangles and triggers the gradual loss of neuronal functions in tauopathies, including Alzheimer’s disease. Herein, we demonstrated...

Deep learning enables fast and dense single-molecule localization with high accuracy

posted 1 day

Mashup Score: 2

bioRxiv - Single-molecule localization microscopy (SMLM) has had remarkable success in imaging cellular structures with nanometer resolution, but the need for activating only single isolated emitters...

bioRxiv - There is a strict interaction between the autonomic nervous system (ANS) and pain, which might involve descending pain modulatory mechanisms. The periaqueductal grey (PAG)...

  • The association between pain-induced autonomic reactivity and descending pain control is mediated by the periaqueductal grey https://t.co/yzfsv38VXI #bioRxiv