bioRxiv - Human embryonic stem cells (hESCs) differentiate into specialized cells, including midbrain dopaminergic neurons (DAN). Non-human primates (NHPs) injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine develop some alterations observed...
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DIET INFLUENCES PERIPHERAL AMYLOID BETA METABOLISM: A ROLE FOR CIRCULATING INSULIN-LIKE GROWTH FACTOR I
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bioRxiv - Obesity is a risk factor for Alzheimer disease (AD), but underlying mechanisms are not clear. We analyzed peripheral clearance of amyloid-beta (Abeta) in overweight...
Loss of Cdk5rap2 triggers cellular senescence via β-catenin-mediated downregulation of WIP1
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bioRxiv - Loss-of-function mutations in Cdk5rap2 is associated with the developmental disorders, primary microcephaly and primordial dwarfism, but the underlying molecular link remains obscure. Here, we...
Genome-wide macroevolutionary signatures of key innovations in butterflies colonizing new host plants
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bioRxiv - The exuberant proliferation of herbivorous insects is attributed to their associations with plants. Despite abundant studies on insect-plant interactions, we do not know whether...
bioRxiv - In species with polygenic sex determination, multiple male- and/or female-determining loci on different proto-sex chromosomes segregate as polymorphisms within populations. The extent to which...
A single-dose live-attenuated YF17D-vectored SARS-CoV2 vaccine candidate
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bioRxiv - The explosively expanding COVID-19 pandemic urges the development of safe, efficacious and fast-acting vaccines to quench the unrestrained spread of SARS-CoV-2. Several promising vaccine...
bioRxiv - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus responsible for the COVID-19 pandemic. Despite recent advances in the structural elucidation of...
bioRxiv - The emergence of SARS-CoV-2 has created an international health crisis. Small animal models mirroring SARS-CoV-2 human disease are essential for medical countermeasure (MCM) development....
Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiota
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bioRxiv - The recognition that the gut microbiome has a profound influence on human health and disease has spurred efforts to manipulate gut microbial community structure...
bioRxiv - Clostridioides difficile is the major worldwide cause of antibiotic-associated gastrointestinal infection. A pathogenicity locus (PaLoc) encoding one or two homologous toxins, toxin A (TcdA)...
Human embryonic stem cells-derived dopaminergic neurons transplanted in parkinsonian monkeys recover dopamine levels and motor behavior https://t.co/qQF73vtGsQ #bioRxiv