Mashup Score:20
bioRxivAn open-source, high resolution, automated fluorescence microscope - 1 week
Mashup Score:20
# biorxiv
Mashup Score:20
bioRxivSPARCS, a platform for genome-scale CRISPR screening for spatial cellular phenotypes - 6 days
Mashup Score:20
Forward genetic screening associates phenotypes with genotypes by randomly inducing mutations and then identifying those that result in phenotypic changes of interest. Here we...
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SPARCS, a platform for genome-scale CRISPR screening for spatial cellular phenotypes https://t.co/e36Jy9mnWd #bioRxiv - view on twitter
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Mashup Score:15
bioRxivSingle-chain fluorescent integrators for mapping G-protein-coupled receptor agonists - 3 days
Mashup Score:15
GPCRs transduce the effects of many neuromodulators including dopamine, serotonin, epinephrine, acetylcholine, and opioids. The localization of synthetic or endogenous GPCR agonists impacts their...
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Single-chain fluorescent integrators for mapping G-protein-coupled receptor agonists https://t.co/rjr6RwKETi #bioRxiv - view on twitter
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Mashup Score:14
bioRxivAmyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer’s Disease - 1 day
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Several microglia-expressed genes have emerged as top risk variants for Alzheimer′s disease (AD). Impaired microglial phagocytosis is one of the main proposed outcomes by...
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Amyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer's Disease https://t.co/fhzcjwPtj7 #bioRxiv - view on twitter
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Mashup Score:12
bioRxivStructure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex - 6 days
Mashup Score:12
The unc-51-like kinase protein kinase complex (ULK1C) and the class III phosphatidylinositol (PI) 3-kinase complex I (PI3KC3-C1) are the most upstream and central players...
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Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex https://t.co/GnolZ2Wzjp #bioRxiv - view on twitter
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Mashup Score:9
bioRxivHuman Rhinoviruses: a novel class of oncolytic virus - 3 days
Mashup Score:9
In continuing to develop new and improved OVs, researchers have been vigilant in optimizing their ability to selectively infect and replicate within tumors and...
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Human Rhinoviruses: a novel class of oncolytic virus https://t.co/irEpnpc8tk #bioRxiv - view on twitter
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bioRxivMetabolic regulation of misfolded protein import into mitochondria - 7 days
Mashup Score:8
Mitochondria are the cellular energy hub and central target of metabolic regulation. Mitochondria also facilitate proteostasis through pathways such as the ‘mitochondria as guardian...
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#PeerReview from @eLife of 👉🏿 Metabolic regulation of misfolded protein import into mitochondria https://t.co/88sDMqB9z7 #bioRxiv #reviewedpreprint - view on twitter
Mashup Score:8
bioRxivA detailed Molecular Network Map and Model of the NLRP3 Inflammasome - 6 days
Mashup Score:8
The NLRP3 inflammasome is a key regulator of inflammation that responds to a broad range of stimuli. The exact mechanism of activation has not...
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A detailed Molecular Network Map and Model of the NLRP3 Inflammasome https://t.co/04wjSfhJRn #bioRxiv - view on twitter
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bioRxivMonitoring GPCR Conformation with GFP-Inspired Dyes - 3 days
Mashup Score:7
Solvatochromic compounds have emerged as valuable environment-sensitive probes for biological research, with the chromophore of the green fluorescent protein (GFP) being a well-studied example....
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Monitoring GPCR Conformation with GFP-Inspired Dyes https://t.co/BJHqMFWn3k #bioRxiv - view on twitter
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bioRxivCryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting - 4 days
Mashup Score:7
We present near-atomic-resolution cryo-EM structures of the mammalian voltage-gated potassium channel Kv1.2 in open, C-type inactivated, toxin-blocked and sodium-bound states at 3.2 Å, 2.5...
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Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting https://t.co/w7kdv039Tp #bioRxiv - view on twitter
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Fluorescence microscopy is a fundamental tool in the life sciences, but the availability of sophisticated equipment required to yield high-quality, quantitative data is a...
An open-source, high resolution, automated fluorescence microscope https://t.co/fhqYYFq4hy #bioRxiv - view on twitter