Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images
posted 12 hours
Mashup Score: 5
bioRxiv - Super-resolution structured illumination microscopy (SR-SIM) pro- vides an up to two-fold enhanced spatial resolution of fluorescently labeled samples. The reconstruction of high quality SR-SIM...
Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model
posted 5 hours
Mashup Score: 5
bioRxiv - The outbreak of coronavirus disease 2019 (COVID-19) rapidly spreads across worldwide and becomes a global pandemic. Remdesivir is the only COVID-19 treatment approved by...
bioRxiv - Over the last three and a half decades the analysis of relationships between traits in comparative data has come to be dominated by the...
Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase
posted 12 hours
Mashup Score: 3
bioRxiv - N6-methyladenosine (m6A) is the most common modification on endogenous RNA transcripts in mammalian cells. Currently, the lack of precise single-nucleotide RNA modification tools makes...
Fight Cancer using your own T-Cells
posted 2 months
Despite recent advancements in immuno-oncology, not all patients with cancer benefit from current treatments, and additional therapeutic options are needed for both hematologic malignancies...
Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control
posted 2 days
Mashup Score: 3
bioRxiv - In humans and nonhuman primates, Mycobacterium tuberculosis lung infection yields a complex multicellular structure: the tuberculosis granuloma. All granulomas are not equivalent, however, even...
bioRxiv - The spatial organization of chromosomes by structural maintenance of chromosomes (SMC) complexes is vital to organisms from bacteria to humans. SMC complexes were recently...
Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis
posted 1 hour
Mashup Score: 3
bioRxiv - Mycobacteria tuberculosis (Mtb) remains the deadliest pathogenic bacteria worldwide. The search for new antibiotics to treat drug-sensitive as well as drug-resistant tuberculosis has become...
A novel equilibrative nucleoside transporter 1 inhibitor alleviates Tau-mediated neurodegeneration
posted 2 days
Mashup Score: 3
bioRxiv - Tau hyperphosphorylation favors the formation of neurofibrillary tangles and triggers the gradual loss of neuronal functions in tauopathies, including Alzheimer’s disease. Herein, we demonstrated...
Deep learning enables fast and dense single-molecule localization with high accuracy
posted 1 day
Mashup Score: 2
bioRxiv - Single-molecule localization microscopy (SMLM) has had remarkable success in imaging cellular structures with nanometer resolution, but the need for activating only single isolated emitters...
The association between pain-induced autonomic reactivity and descending pain control is mediated by the periaqueductal grey
posted 13 hours
Mashup Score: 2
bioRxiv - There is a strict interaction between the autonomic nervous system (ANS) and pain, which might involve descending pain modulatory mechanisms. The periaqueductal grey (PAG)...
Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images https://t.co/TvNs7iWQBm #bioRxiv