# biorxiv

Adrenoleukodystrophy protein (ALDP) is responsible for the transport of free very-long-chain fatty acids (VLCFAs) and corresponding CoA-esters across the peroxisomal membrane. ALDP belongs to...

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  bioRxiv

  Structure insights of the human peroxisomal ABC transporter ALDP https://t.co/RKEiKyYupq #bioRxiv - view on twitter

STIM proteins sense decreases in [Ca2+]ER and cluster in endoplasmic reticulum (ER)-plasma membrane (PM) junctions where they recruit and activate Orai1. While STIM1 clustering...

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  bioRxiv

  Functional Communication between IP3R and STIM2 at sub-threshold stimuli is a critical checkpoint for initiation of SOCE https://t.co/mn5UYav3U5 #bioRxiv - view on twitter

Anticoagulants are associated with clinical benefit against the 2019 coronavirus disease (COVID-19), preventing COVID-19 associated coagulopathy. Blood coagulation factor Xa (FXa) and SARS-CoV-2 major...

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  bioRxiv

  Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication by targeting its major protease in a non-competitive way https://t.co/Fx5B6K7u4M #bioRxiv - view on twitter

The genomic drivers of immune exclusion in colorectal cancer liver metastases (CRCLM) remain poorly understood. Chromosomal instability (CIN), resulting in aneuploidy and genomic rearrangements,...

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  bioRxiv

  Chromosomal instability mediates immune exclusion and response to cytotoxic chemotherapy in colorectal liver metastases https://t.co/clynJARLi0 #bioRxiv - view on twitter

The mechanoelectrical transduction (MET) channel complex of auditory hair cells converts sound into electrical signals, allowing us to hear. After decades of research, the...

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  bioRxiv

  Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channelsis essential for hearing https://t.co/lYELf99WpE #bioRxiv - view on twitter

Lung cancer treatment has benefited greatly from the development of effective immune-based therapies. However, these strategies still fail in a large subset of patients....

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  bioRxiv

  KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance https://t.co/sQkCxCzoEt #bioRxiv - view on twitter

FDA-approved and Emergency Use Authorized (EUA) vaccines using new mRNA and viral-vector technology are highly effective in preventing moderate to severe disease, however, information...

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  bioRxiv

  Protein Vaccine Induces a Durable, More Broadly Neutralizing Antibody Response in Macaques than Natural Infection with SARS-CoV-2 P.1 https://t.co/OKpqScxaXW #bioRxiv - view on twitter

Low grade gliomas (LGG) account for about two-thirds of all glioma diagnoses in adolescents and young adults (AYA) and malignant progression of these patients...

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  bioRxiv

  Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity and Restricted Cytotoxic Effector Cell Trafficking and Activation During Malignant Progression in Glioma https://t.co/SKhji8304B #bioRxiv - view on twitter

Current treatments for trauma-related disorders remain ineffective for many patients. Here, we modeled interindividual differences in post-therapy fear relapse with a novel ethologically relevant...

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  bioRxiv

  Post-trauma behavioral phenotype predicts vulnerability to fear relapse after extinction https://t.co/A5js9UARlH #bioRxiv - view on twitter