Mashup Score:22
bioRxivPancreatic tumors activate arginine biosynthesis to adapt to myeloid-driven amino acid stress - 5 days
Mashup Score:22
# biorxiv
Mashup Score:12
bioRxivCell-intrinsic response patterns control risks arising from genome-damaged cells, preventing malignant transformation. p53-dependent DNA damage responses halt the cell cycle and induce either repair,...
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Clearance of genome-damaged cells from the hematopoietic system via p53 without contribution by the cGAS/STING axis https://t.co/9saDMc0btb #bioRxiv - view on twitter
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Mashup Score:10
bioRxivStructure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A - 1 week
Mashup Score:10
TMEM87s are eukaryotic transmembrane proteins with two members (TMEM87A and TMEM87B) in humans. TMEM87s have proposed roles in protein transport to and from the...
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Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A https://t.co/m0JphheR5g #bioRxiv - view on twitter
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Mashup Score:10
bioRxivUbiquitin and ubiquitin-like conjugation cascades consist of dedicated E1, E2 and E3 enzymes with E3s providing substrate specificity. Mass spectrometry-based approaches have enabled the...
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SUMO Activated Target Traps (SATTs) enable the identification of a comprehensive E3-specific SUMO proteome. https://t.co/9rNFKNPsIG #bioRxiv - view on twitter
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Muscle weakness and atrophy are clinical hallmarks of myotonic dystrophy type 1 (DM1). Muscle stem cells, which contribute to skeletal muscle growth and repair,...
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Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1. https://t.co/kIN9aYLpeG #bioRxiv - view on twitter
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Mashup Score:9
bioRxivTherapeutic antibody efficacy is largely determined by the target epitope. In addition, off-target binding can result in unanticipated side-effects. Therefore, characterization of the epitope...
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A unified peptide array platform for antibody epitope binning, mapping, specificity and predictive off-target binding https://t.co/esxRG2riVX #bioRxiv - view on twitter
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Mashup Score:9
bioRxivAdvanced prostate cancer comprises distinct tumor phenotypes, but tumor classification remains clinically challenging. Here, we harnessed circulating tumor DNA (ctDNA) to study tumor phenotypes...
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Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes https://t.co/DUhthoO3zi #bioRxiv - view on twitter
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Mashup Score:9
bioRxivTranscription factor Nrf2 (nuclear factor, erythroid 2-like 2, encoded by Nfe2l2) has been accepted as a key player in redox regulatory responses to oxidative...
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Distinct roles of Nrf1 and Nrf2 in monitoring the reductive stress response to dithiothreitol (DTT) https://t.co/vEfViyYHPF #bioRxiv - view on twitter
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Mashup Score:8
bioRxivThe regulation of muscle stem cell (MuSC) asymmetric division plays an essential role in controlling the growth and repair of skeletal muscle. We discover...
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KDR Signaling in Muscle Stem Cells Promotes Asymmetric Division and Progenitor Generation for Efficient Regeneration https://t.co/G5jWfQHQi6 #bioRxiv - view on twitter
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Mashup Score:8
bioRxivHumanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism - 4 days
Mashup Score:8
SARS-CoV-2 Omicron variants have generated a world-wide health crisis due to resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of antibodies induced by...
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Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism https://t.co/p6cQd9Rm2W #bioRxiv - view on twitter
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Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs to maintain survival and proliferation. Therefore, knowledge of microenvironmental nutrient...
Pancreatic tumors activate arginine biosynthesis to adapt to myeloid-driven amino acid stress https://t.co/hxOPWz5y7q #bioRxiv - view on twitter