Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations

Diverse Middle Pleistocene forms of Homo coexisted in Africa, Europe, and Asia. It is very controversial whether these fossil humans represent different species or lineages.…

As we enter the era of CRISPR medicines, base editors (BEs) emerged as one of the most promising tools to treat genetic associated diseases. However,…

Phytochromes are photoreceptor proteins in plants, fungi and bacteria. They can adopt two structurally distinct photochromic states with differential biochemical responses. The structural changes transducing…

The regulation of cell-specific gene expression patterns during development requires the coordinated actions of hundreds of proteins, including transcription factors, processing enzymes, and many RNA…

Nucleoside-modified mRNA vaccines elicit protective antibodies through their ability to promote T follicular helper (Tfh) cells. The lipid nanoparticle (LNP) component of mRNA vaccines possesses…

Sensory deprivation reshapes developing neural circuits, and sensory feedback adjusts the strength of reflexive behaviors throughout life. Sensory development might therefore limit the rate with…

Background: Medulloblastoma (MB) is the most malignant childhood brain cancer. Group 3 MB subtype accounts for about 25% of MB diagnoses and is associated with…

In malaria infection, early eryptosis eliminates the protective niche provided by the infected erythrocyte, thus potentially interfering with the parasite survival rate in the human…

Language models have enabled a new era of biological sequence modeling. However, extracting meaningful sequence-level embeddings from these models remains challenging. In this work, we…