Gopee and colleagues’ recent analyses of diverse high-dimensional datasets of prenatal and adult skin, together with data from complex skin organoids, uncover the important contributions of macrophages in modulating prenatal skin development, scarless wound healing, and angiogenesis. These findings identify a role for skin immune cells in tissue development.
In this editor’s choice, we celebrate the spirit of Nexus: “Where science and engineering meet.” We highlight five pioneering articles that exemplify the transformative power…
The AAAAI has allergy-free play dough recipes for your children, students or scouting projects.
Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.
Mast cells act as “signal converters,” translating immunological and tissue signals into host-protective behaviors. They sense antigen and possibly toxins driving avoidance behavior, which can…
Spatial and molecular profiling of 117 tumors before and after chemotherapy reveals a dynamic tumor ecosystem in ovarian cancer. Launonen et al. identify Myelonets as drivers…
Johal et al. show that ALDH7A1-deficient cells and mice accumulate lysine metabolites via the saccharopine pathway, which are thought to cause seizures in patients with pyridoxine-dependent…
Yang et al. identify CD49f as a prominent tumor-initiating cells (TIC) marker in HCC and reveal a reciprocal loop between CD49f-high TICs and neutrophils that promotes…
The axe, which Ben found on Shoreham Beach when he was six, could be up to 60,000 years old.
CD4+ T helper (Th) cell differentiation depends on regulatory networks that enforce lineage commitment while suppressing alternative fates. In a recent issue of Nature, Hou…
Chadha et al. demonstrate that Legionella pneumophila manipulates host cell membranes to form the Legionella-containing vacuole (LCV), which is distinct from the host rough ER. This…
