Related Articles
Safety and efficacy of RCP recombinant spike protein covid-19 vaccine compared to Sinopharm BBIBP: A phase III, non-inferiority trial
We conducted a phase III, non-inferiority trial comparing safety and efficacy of RCP recombinant spike protein Covid-19 vaccine to BBIBP (Sinopharm).
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate
Schrepfer and colleagues engineered hypoimmune (B2M−/−, CIITA−/−, CD47+) primary rhesus macaque pseudo-islets. They were transplanted into a fully allogeneic, immunocompetent, diabetic, and insulin-dependent cynomolgus monkey…
Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe
Kerner et al. analyze ancient human genomes to reconstruct the history of host-pathogen interactions over the last 10,000 years. They found that genetic adaptation has occurred…
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells
Wang et al. establish feasible methodologies to generate highly functional CAR T cells from T-cell-derived iPSCs using 3D-organoid cultures, thereby supporting the development of “off-the-shelf” manufacturing strategies.
Highly local activation of inhibition at the seizure wavefront in vivo
Shah et al. describe an approach to measure single-neuronal excitability at large scale in a mouse model of epilepsy in vivo and show that neuronal excitability is…
Natural history of Ebola virus disease in rhesus monkeys shows viral variant emergence dynamics and tissue-specific host responses
Normandin et al. explored temporal and spatial host-pathogen dynamics in Ebola virus disease through a natural history study in rhesus monkeys. Bulk transcriptomics of over 400…
Ancient Mycobacterium leprae genome reveals medieval English red squirrels as animal leprosy host
Urban et al. identify medieval English red squirrels as an animal host for Mycobacterium leprae by genetic evidence. Their One Health approach using historical sources, zooarchaeology,…
A base editing strategy using mRNA-LNPs for in vivo correction of the most frequent phenylketonuria variant
The PAH c.1222C>T variant is the most frequent variant reported in phenylketonuria (PKU) individuals. Here, the authors use base editing, delivered by mRNA-lipid nanoparticle technology,…
Cell Press: STAR Protocols
STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all…
B cell-derived cfDNA after primary BNT162b2 mRNA vaccination anticipates memory B cells and SARS-CoV-2 neutralizing antibodies
Fox-Fisher and colleagues employed methylation-based cfDNA biomarkers to assess immune cell turnover following SARS-CoV-2 vaccination. The primary vaccination elicited elevated levels of B cell cfDNA,…