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    Research ArticleCardiology Open Access | 10.1172/jci.insight.161788 Peter J. Kennel,1 Bohao Liu,2 Trevor R. Nash,2 Richard Z. Zhuang,2 Amandine F. Godier-Furnemont,2 Chenyi Xue,1 Rong Lu,1 Paolo C. Colombo,1 Nir Uriel,1 Muredach P. Reilly,1 Steven O. Marx,1 Gordana Vunjak-Novakovic,2 and Veli…

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    • Excited to share new research from our laboratory led by @xhliao1 and @peterjkennel on Epigenetics of Heart Failure, Recovery with LVAD, and discovery of LINC00881 as a novel target. Grateful to our collaborators ReillyLab, @NirUrielMD, @GVNLab, @SMarxLab. https://t.co/qpQfjKqvbi https://t.co/MIo6nKUUBG

  • Mashup Score: 4

    Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. In the present study, we uncover the primary mechanism underlying the heart’s innate contractile reserve. We show that four protein kinase A (PKA)-phosphorylated residues in Rad, a calcium channel inhibitor, are crucial for controlling basal calcium current and essential for β-adrenergic…

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    • RT @ElaineWanMD: 🔥off the press now @NatureCVR, Rad regulation of calcium channels in beta adrenergic modulation https://t.co/WQ6Kk2wqip. H…