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Mashup Score: 20High-Dimensional Analyses Reveal IL15 Enhances Activation of Sipuleucel-T Lymphocyte Subsets and Reverses Immunoresistance - 24 day(s) ago
AbstractSipuleucel-T (sip-T) is the only FDA-approved autologous cellular immunotherapy for metastatic castration-resistant prostate cancer (mCRPC). To elucidate parameters of the response profile to this therapy, we report high-dimensional analyses of sip-T using cytometry by time of flight (CyTOF) and show a lymphoid predominance, with CD3+ T cells constituting the highest proportion (median ∼60%) of sip-T, followed by B cells, and natural killer (NK) and NKT cells. We hypothesized that treatment of sip-T with homeostatic cytokines known to activate/expand effector lymphocytes could augment efficacy against prostate tumors. Of the cytokines tested, IL15 was the most effective at enhancing activation and proliferation of effector lymphocytes, as well as augmenting tumor cytotoxicity in vitro. Co-culture of sip-T with IL15 and control or prostate-relevant antigens showed substantial activation and expansion of CD8+ T cells and NKT cells in an antigen-specific manner. Adoptive transfer
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4Tumor Frameshift Mutation Proportion Predicts Response to Immunotherapy in Mismatch Repair-Deficient Prostate Cancer - PubMed - 5 month(s) ago
Given the modest efficacy of immune checkpoint inhibition (ICI) in unselected patients with advanced prostate cancer, biomarkers of ICI sensitivity are needed. To facilitate biomarker discovery, a cohort of patients with DNA mismatch repair-deficient (dMMR) prostate cancer was assembled, as these pa …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
Also “flavor/quality” of what makes up “TMB” is important…great paper from @laurasenamd @EAntonarakis et al looking at an aspect of this: https://t.co/YiYeeRrWoV https://t.co/xCDqpGdAqh
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Mashup Score: 4Program Guide – ASCO Meeting Program Guide - 11 month(s) ago
AuthorsJesse Meir ZaretskyWashington University School of Medicine, Department of Medicine, Division of Oncology, St. Louis, MOJesse Meir Zaretsky, Dhruv Bansal, Muhammad Azeem Saeed, Bo Peng, Jingqin Luo, Jessica Klette, Melissa Andrea Reimers, Russell Kent PachynskiOrganizationsWashington University School of Medicine, Department of Medicine, Division of Oncology, St. Louis, MO, Saint Lukes…
Source: meetings.asco.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
👉 be sure to stop by our CABIOS Trial poster at #ASCO23 ✅ Frist trial of cabo/nivo in mHSPC ✅ Phase Ib with no DLTs ✅ Prelim ⬇️in Tregs/MDSC/TGFb, ⬆️IL2/NK/Th1 Promising, but need RCT PhII @MReimersMD @SitemanCenter @WashUOnc https://t.co/XWsFZotzn4
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Mashup Score: 4Bioinformatics Research Analyst - Oncology - 11 month(s) ago
Scheduled Hours 40 Position Summary Provides critically complex research and experimentation for department/s allowing the advancement of scientific analysis and discovery. Serves as a subject matter expert offering support, training and guidance relative to the discipline/area. May participate and/or present on the research developed, or the established work of those within the department. Job…
Source: wustl.wd1.myworkdayjobs.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @ChrisMaher_Lab: We are currently recruiting a #Bioinformatics Analyst https://t.co/11hdwsAKAG https://t.co/a8D6EqpCP3
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Mashup Score: 0Conferences | Keystone Symposia - 1 year(s) ago
Privacy Policy Terms of Use © 2023 Keystone Symposia on Molecular and Cellular Biology | Registered 501(c)(3). EIN: 84-1326605
Source: www.keystonesymposia.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
It’s been a minute since I’ve been back to #VancouverBC but excited to speak at the @KeystoneSymp meeting about #prostatecancer 🎉; summer #PNW is great- I can see why @PGrivasMDPhD likes this region! 😉 @WashUOnc @SitemanCenter https://t.co/t5mvuQsd77
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Mashup Score: 1
Freed from crippling back pain, a young woman has fulfilled her dream of becoming an elementary school teacher thanks to UCI Health spine surgeon Dr. Nitin Bhatia. “I’m now finishing my second year of teaching and my life today couldn’t be more different than it was before surgery,” says Talia Ryan. “I went from being in constant pain and not being able to do daily tasks to being active all day…
Source: www.ucihealth.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @NitinBhatiaMD: Keeping up with fourth-graders thanks to spine surgery. https://t.co/ByoPwRrULO
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Mashup Score: 0Weather Report - Birdland - 1 year(s) ago
This is from the Stadthalle Offenbach Concert that took place 1978.
Source: YouTubeCategories: Hem/Oncs, Latest HeadlinesTweet-
We can do it!! 💪🏼🎉…will @BReinfeld have to wear red shorts and go shirtless? 🤔🤣🤷🏻♂️ https://t.co/KJ0iDOqRt5 https://t.co/EJBKDEdFCf
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Mashup Score: 3Daniel Petrylak on Prostate Cancer Latest Data on Pembrolizumab Plus Docetaxel - The ASCO Post - 1 year(s) ago
2023 ASCO Genitourinary Cancers Symposium Daniel P. Petrylak, MD, of the Yale Cancer Center, discusses phase III findings from the KEYNOTE-921 study, which was designed to assess the combination of pembrolizumab and docetaxel in the treatment of patients with metastatic castration-resistant prostate cancer. They had not received chemotherapy, but their disease progressed on the…
Source: ascopost.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @ASCOPost: Daniel P. Petrylak, MD, on Prostate Cancer: Latest Data on Pembrolizumab Plus Docetaxel https://t.co/5nySeax1Sq #pcsm #prosta…
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Mashup Score: 0Program Guide – ASCO Meeting Program Guide - 1 year(s) ago
AuthorsPadmanee SharmaMD Anderson Cancer Center, Houston, TXPadmanee Sharma, Michael Krainer, Fred Saad, Daniel Castellano, Jens Bedke, Mariusz Kwiatkowski, Akash Patnaik, Giuseppe Procopio, Pawel Wiechno, Samith Thomas Kochuparambil, Christian Thomas, Jose Angel Arranz Arija, Steven L. McCune, Steinbjorn Hansen, Gedske Daugaard, Neha P. Amin, Yumeng Wang, Justin M. David, Russell Kent…
Source: meetings.asco.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
Excited for #GU23 @ASCO and to present results from the RCT Ph II CheckMate 650 in post-doce mCRPC comparing ipi/nivo vs cabazitaxel. Huge thanks to @PamSharmaMDPhD for leading the effort, and all involved. @cdanicas @AkashPatnaik7 👇 https://t.co/iSFkAZ6UCG
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Mashup Score: 2Bioinformatics Research Assistant - Radiation Oncology - 1 year(s) ago
Should I consider applying to older job postings? Yes. Due to the unique needs of each search, the selection process may occur at different paces for open positions. Individuals are encouraged to apply to all open positions of interest for which they meet the Required Qualifications. Washington University’s collective success is greatly attributed to the passion and outstanding efforts of our…
Source: wustl.wd1.myworkdayjobs.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @jinwashu: Bioinformatics Research Assistant position in my lab: https://t.co/reCHkET1eN
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👉How do you improve the only FDA approved cellular therapy for #prostatecancer ? ✅out our newest work in @CIR_AACR #AACR24 👉First deep analysis of Sip-T & est'd preclinical model. thx 2 @bvantine1 @LabFehniger @Pachynski_Lab https://t.co/rleIqpMAtK